Reddit Posts
TIL: Canadians pay only 5% more total taxes than Americans on income upto 100k and get free education, healthcare and 4 months of maternity leave. Is US tax system really the “most progressive” in the world as Jeff Bezos says?
TIL about BlackRock, how can I setup similar company?
$IOVA Announces Lung Data Pre Market
$IOVA -TIL Therapy Showing Real Teeth in NSCLC (Potential Multi-Bagger Long-Term) - Report dropped 50mins ago
$IOVA - TIL Therapy Showing Real Teeth in NSCLC (Potential Multi-Bagger Long-Term) - Report dropped 50 minutes ago, already subtancially up
TIL about Dark Pools. SEC, what is it you do again? 🤨
IOVA Due Diligence, why I am investing in it
From Lab to Market: Why This Innovative Cancer Therapy Stock Will Soar
TIL $NVDA replaced Enron in the S&P 500 index in 2001.
TIL - if you sell options, for tax purpose its *always* considered short term capital gain/loss
TIL: Sinclair broadcasting group is a publicly traded company under SBGI.
Iovance (IOVA) having a nice day—is it a buy for you?
TIL You can monitor Asian markets to kinda guess next morning moves
IOVANCE (IOVA) is straight-up screaming moooon and heres why
TIL: Apple's spends $8B+ on R&D and still we have a dumb Siri?!
TIL: Apple's spends $8B+ on R&D and still no we have same Siri?
TIL options can be exercised 1.5 hours after the market closes.
ASCO coming in hot, I built a mini biotech watchlist before the data flood
TIL Chicago commodities traders are degens just like us
TIL: If I made $3300 today, but I lost $24,600 this month, I haven't really made anything. AMA.
Week 1 of the NO MORE BS WORK TIL I die playbook. These were my moves and they still have plenty of room to grow more
TIL Rep. Debbie Dingell just bought Walmart stock - anyone else watching politicians' portfolios these days?
TIL that fractional shares are actually CFDs, is that true?
TIL that energy stocks are actually war stocks!
TIL: Securities Used To Be Considered Property but are now Considered "Entitlements"
TIL Nvidia triple top is not a meme
Execution Speed, OCO Orders, and the Mystery of GOOD TIL CANCEL on TOS. Please help!
3 red hot penny stocks to watch before next week—time to buy?
TIL the TV series Billions is considered fictional because it implies federal regulators are incentivized to prevent systemic financial crimes!
TIL Sometimes "safety" costs you a lot of money.
Mentions
TIL Bibi is the President of the US of A 🤦♀️
TIL Saudi Arabia is a Republic and has a President
I was TIL years old when I found out there's women's professional ice hockey
TIL all this redistricting shenanigans actually impacts your networth. Can drop the value of your home 8% or more.
Didn't realize that the stock market started in 2015, TIL
TIL, SpaceX's data center revenue will be the largest revenue stream on earth in a few years.
TIL I'm talking to bots 🤡
TIL my broker will wash my windows
The market isn't open on Monday? TIL, thanks.
TIL I love doing opposite of making money.
TIL. Weeklies aren't that bad compared to 0dte, hence my misconception.
TIL: the chilled helium on stranded ships evaporates after about six weeks
TIL Vin Diesel's character "Vin Diesel" in the Fast and the Furious is a nod to cars (VIN number) and trucks (diesel). wild
TIL bond yields never matter until they do
TIL Elon lost lawsuit against OpenAI because statue of limitations passed
Hey, TIL. Thats pretty neat and not something I would have thought would happen.
They make whole pizzas not just pizza rolls?? Lol TIL
> It'll be costly in the immediate future, but you only have to do it once. TIL future strikes can never happen again.
TIL, and I can't believe I just wasted time googling that dude: [https://www.reddit.com/r/wallstreetbets/comments/qmynba/the\_legend\_of\_utheemperorofjenks\_aka\_ornamental/](https://www.reddit.com/r/wallstreetbets/comments/qmynba/the_legend_of_utheemperorofjenks_aka_ornamental/)
TIL you can buy puts and calls on SGOV
TIL boomer stocks have reasonable fundamentals and actual earnings.
TIL you’re not supposed to eat the leaves
TIL there is a blackstone and a blackrock.
TIL: There's no need for semis and memory anymore
TIL forever means up to 15 may 2026
TIL; no one cares about gas prices nothing can solve this traffic problem
TIL Merrill's platform looks like shit. Anyways, congrats on the win OP.
TIL reddit went public... lol
TIL space data centers isn’t just a meme and that there are people more retarded than me
TIL we are not a country, just a ragtag bunch of billionaire corporations.
TIL there are companies growing mushroom roots to build renewable replacements for plastics which is killing us but also derived from oil and running out. Damn why don't we invest trillions in these companies? Instead of blanketing the earth in useless AI slop.
TIL there is an etf called NASA. it has exposure to SpaceX 🤔
I remember like 5 years ago CSCO was a “value” stock that would forever be in 40-50s. TIL its over $100 again.
TIL Samsung and SK Hynix workers are unionized, I’m so used to American companies stomping all unionization efforts
TIL microplastics exposure to our children and all of us is increasing exponentially. Moreover, the brain has 30 times the accumulation of microplastic than the liver, the organ and site with the second highest amount. Once it crosses the blood-brain barrier it never crosses back. Humans are probably beyond saving. Inflation will never be tamed. Debt is spiraling way faster than the economy. Give me one good reason why I shouldn't just liquidate my 401k, sell whatever stocks I have and just spend all my savings to live like a king for the next 20 years?
TIL there is a stock BLSH for a company literally named Bullish 🔥
Also TIL that asking RC how it would work was actually a bad faith gotcha question.
TIL higher CPI is bullish LOL
\> "Just -0.2% on the S&P HAHA!" \> "BERS ONLY GET THEIR 20MIN EACH DAY" \> "AI BACKLOG TIL 2090" \> "V!!!!" \> "RED IS BANNED" \> "BELIEVE IT OR NOT, CALL IT IS" \> "TACO TUESDAY" plz tell me this is going to end well for us
TIL: There is more than one General Tsao. There are thousands, if not tens of thousands. Calls on china’s military-industrial complex. Calls on gyanese defense stonks.
TIL Saddam had more taste than trump
https://en.wikipedia.org/wiki/Chord_(geometry) TIL
TIL theres a tel aviv stock exchange
TIL: Hussain means good, handsome or beautiful. Already knew John meant toilet and trump meant fart.
TIL: Ber Jesus wears black instead of white.
TIL 🥭 pardoned nikola ceo because he donated $3.2 million to his campaign..
TIL that RH automatically exercises call options that are ITM by even .01 at close if you have the buying power. No RH, I did not want another 100 shares of ASTS the day before a unpredictable weekend and their earnings, especially at $75 fucking dollars. If I wanted another 100 shares I would have bought them a few days ago.
TIL that a ceasefire means you can still shoot SPY +2%
TIL I’m good at picking stocks that beats earnings but can never tell which way they go
Shake Shack is publicly traded??? TIL.
I considered this post and discussion could be brainrot, but I did not know what brainrot was. TIL: In Internet culture, the term brain rot (often written as brainrot) describes digital media deemed to be of low quality or value, to such a degree that it is ironically spoken of as causing harm to the viewer.
TIL Nokia is an actual stock and not a meme
TIL Cloudflare does AI shit. I thought they just did security with those lava lamps
It's kind of funny that so much of corporate America treats any sort of CEO/founder/executive relationships as a major no-no, and then Elon is out here having executives/board members of his companies have his children. Related TIL that an OpenAI board member had 4 of his kids.
TIL Dutch Bros is publicly traded
TIL Tobacco companies were the ones that engineered these processed foods to maximize our reward signal
TIL bers are not only ghey, they are also a masochist
TIL Iranians don’t understand sarcasm 😔
TIL Kelly Loeffler heads the Small Business Administration and her husband is chairman of the New York Stock Exchange lmao
TIL lierotica is a real thing.
TIL I learned that NVDA has a higher market cap than Germany's GDP.
TIL the original version of "Let's get it started" was "let's get retarded" I propose we make it our official song.
TIL Sauron was a daytrader
Congrats, Bud!! I was down 40% and finally got back to even Steven last week. Had mental meltdowns and anxiety attacks but recover. NEVER STOP FIGHTING TIL THE FIGHT IS DONE!!!🤗
TIL googl and meta are not in the XLK. looney toons
TIL, I can retire at onto easy st with 700k 💡
TIL from zerohedge: sellers only show up at the top 🤣
TIL Doctor Phil used to be a Fed chair
i thought that was a cleavage. TIL I'm legally blind
TIL Intel was nationalized and I completely missed the announcement.
TIL Alan Greenspan is 100 years old, is married to CNN's Andrea Mitchell, and his first wife's last name also had the last name Mitchell.
TIL US "Paper" money is actually made of cotton. So money does kinda grow on trees.
TIL semis meant semiconductors, not semi trucks.
TIL 60 billion annual profit = hot garbage
TIL the gum't has made $31 Billion on a $9 billion investment in INTC 450% annualized return
TIL I’m rich. Why can’t I retire then?
TIL semis meant semiconductors, not semi trucks. My dumb ass was about to short some trucking companies.
TIL Young Thug is one of the 30 greatest living American songwriters
It isn't just the biotech sector. For the past 10, almost 20 years, most corporation have trend towards downsizing or completely eliminated their R&D department in a bid to focus on the operational and business verticals. Most corporation aren't willing to underwrite R&D risk anymore. This has led to the rise and flourishing of startups that, if successful, are acquired, to be integrated into the core business of the buying company. I had a good part of my feet on the venture capital side and quant side of my professional career. **Iova is worth looking into.** They have two lines of product: Amtagvi (FDA approved for advanced melenoma with best in - class ORR, with consistency shown years after FDA approved) and Proleukin. >**52% Amtagvi Response Rate with Two or Fewer Prior Lines of Therapy 73% Overall Disease Control Rate** >SAN CARLOS, Calif., Feb. 05, 2026 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a commercial biotechnology company focused on innovating, developing, and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer, today announced data demonstrating a best-in-class profile for commercial Amtagvi^(®) (lifileucel) with unprecedented response rates in a real-world clinical, retrospective study in patients with advanced (unresectable or metastatic) melanoma. Amtagvi is the first one-time T cell therapy for a solid tumor cancer as well as the only FDA-approved treatment for advanced melanoma patients previously treated with anti-PD-1 and targeted therapy, where applicable. >The real-world results were highlighted in an [oral presentation](https://www.iovance.com/scientific-publications-presentations/) at the 2026 Tandem Meetings of the American Society for Transplantation and Cellular Therapy (ASTCT^(®)) and the Center for International Blood and Marrow Transplant Research (CIBMTR^(®)) in Salt Lake City, UT. >Forty-one evaluable patients with previously treated advanced melanoma received commercial Amtagvi according to the U.S. prescribing information at four authorized treatment centers. The physician-assessed confirmed objective response rate (ORR) was 44% (18/41) and the disease control rate was 73% (30/41). Response rates were higher with earlier Amtagvi treatment. The ORR was 52% (12/23) following two or fewer lines of therapy compared to an ORR of 33% (6/18) after three or more lines of therapy. The unprecedented real-world response rates also improved upon the 31% ORR in the C-144-01 clinical trial that supported the U.S. FDA accelerated approval of Amtagvi. >Lilit Karapetyan, MD, MS of H. Lee Moffitt Cancer Center & Research Institute stated, “The real-world response rate builds on existing clinical data and supports consideration of lifileucel as soon as possible after immune checkpoint inhibitor treatment. An overall response rate of 44% was observed in the full cohort, with a 52% response rate among patients treated in earlier lines of therapy. I am encouraged by the potential for an increasing number of patients to benefit as adoption of TIL therapy continues.” >Daniel Kirby, Chief Commercial Officer of Iovance, stated, “The real world Amtagvi data with impressive response rates, paired with unprecedented five-year durability and survival data, demonstrate a best-in-class profile and better outcomes in patients treated earlier.” >Previously treated advanced melanoma represents an unmet medical need with more than 8,000 annual U.S. deaths.^(1) More than half of patients treated with first line standard of care will progress within 12 months.^(2) The U.S. FDA granted accelerated approval for Amtagvi in February 2024 based on ORR and duration of response (DOR) from the C-144-01 clinical trial. The published [final five-year analysis](https://ascopubs.org/doi/10.1200/JCO-25-00765) demonstrated unprecedented durability and follow-up in previously treated advanced melanoma patients, with \~31% ORR, median DOR of 36+ months, and a 20% five-year overall survival.^(3) Iovance is conducting TILVANCE-301, a Phase 3 clinical trial in frontline advanced melanoma, to confirm clinical benefit. >1. National Cancer Institute Surveillance, Epidemiology and End Results (SEER) Program. 2025 Estimates. [https://seer.cancer.gov](https://seer.cancer.gov/) (accessed February 2026) 2. Larkin J, et al. NEJM; Robert C, et al. Lancet; Tawbi HA, et al. NEJM 3. Medina T, et al. JCO Source: [https://ir.iovance.com/news-releases/news-release-details/best-class-real-world-data-support-early-amtagvir-treatment](https://ir.iovance.com/news-releases/news-release-details/best-class-real-world-data-support-early-amtagvir-treatment) **Using what made Amtagvi/ lifileucel successful, Iova has made positive in-road into cell therapy for soft tissue sarcomas with a high 50% ORR.** >Iovance Announces Positive Results from the First Clinical Trial for TIL Cell Therapy in Soft Tissue Sarcomas *50% Objective Response Rate (ORR) in Advanced Sarcomas* >*Significant Market Opportunity with More than 8,000 Patients Diagnosed* *Annually in the U.S. and Europe* >SAN CARLOS, Calif., Feb. 24, 2026 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a commercial biotechnology company focused on innovating, developing, and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer, today announced positive early data from a [pilot clinical trial](https://clinicaltrials.gov/study/NCT05607095?cond=sarcoma&intr=TIL&rank=6) led by Memorial Sloan Kettering Cancer Center (MSKCC) and supported by Iovance of lifileucel in patients with advanced (metastatic or unresectable) undifferentiated pleomorphic sarcoma (UPS) or dedifferentiated liposarcoma (DDLPS) who were refractory to at least one prior line of systemic therapy. >Among the first six evaluable patients treated with lifileucel monotherapy, physician-assessed confirmed ORR by RECIST v1.1 was 50%. All evaluable patients had advanced disease, were refractory to prior therapy, and had significant disease burden, with a mean sum of diameters of 117 millimeters at baseline and a mean of more than two prior lines of therapy. Patients experienced deep responses that improved over time, consistent with lifileucel in melanoma, non-small-cell lung cancer, and other solid tumors. The safety profile was favorable and consistent with lifileucel therapy in other indications. Based on these results, Iovance plans to commence a single arm registrational trial in second-line advanced UPS and DDLPS in the second quarter of 2026 and will engage with the U.S. Food and Drug Administration (FDA) on an accelerated path to expedite approval. Iovance also plans to explore lifileucel in other high grade soft tissue sarcoma subtypes with high unmet need as part of its clinical development program. >UPS and DDLPS are high grade, aggressive soft tissue sarcomas associated with poor prognosis that impact more than 3,000 patients in the U.S. and more than 5,000 patients in Europe annually, including more than 3,500 patients with advanced disease.^(1-3) There is a high unmet medical need for new treatment options for second-line patients with recent clinical studies reporting ORRs of less than 5%, median progression-free survival (mPFS) of \~2-3 months, and median overall survival (mOS) of \~9-10 months.^(4-6) >Lauren Baker Banks, MD, PhD, Sarcoma Medical Oncologist, MSKCC, stated, “In the first clinical trial of a TIL cell therapy in UPS and DDLPS, one-time treatment with lifileucel demonstrated compelling and unprecedented response rates with the potential to address a significant unmet need in patients who are refractory to frontline standard of care. Patients with UPS and DDLPS suffer from high disease burden, poor quality of life, and a lack of effective treatments, including no approved immunotherapy options. In the second-line setting, mPFS for many patients is only a few months with mOS less than a year. We look forward to presenting these results at a medical conference in 2026.” >Dr. Brian Gastman, EVP Translational Medicine and Research at Iovance, stated, “The exciting clinical results show that lifileucel could offer a new, highly efficacious, and durable immunotherapy option in two aggressive forms of advanced sarcoma and further illustrate the promise of our TIL cell therapy platform to offer meaningful clinical benefit in multiple solid tumor cancers. Chemotherapy with extremely poor efficacy remains the second-line standard of care for these patients after progression on front-line chemotherapy. We look forward to bringing lifileucel to UPS and DDPLS patients as quickly as possible.” Source: [https://ir.iovance.com/news-releases/news-release-details/iovance-announces-positive-results-first-clinical-trial-til-cell](https://ir.iovance.com/news-releases/news-release-details/iovance-announces-positive-results-first-clinical-trial-til-cell) More: [https://ir.iovance.com/news-events/press-releases](https://ir.iovance.com/news-events/press-releases)
Humm... TIL, only 14 states have laws for mandatory programs, with 3 more states in the pipeline to mandate.
TIL Twitch streamers make more than me.
TIL there's a woman who got arrested for making an online joke about Netanyahu wtf?!
TIL xiaomi has an LLM & I follow LLM news
Wait. You can actively trade that many gains in a TFSA? TIL. Update us how tax season goes.
> you bullied his grand son TIL a bit more about Nana than was ever expected