Reddit Posts
TIL that fractional shares are actually CFDs, is that true?
TIL that energy stocks are actually war stocks!
TIL: Securities Used To Be Considered Property but are now Considered "Entitlements"
TIL Nvidia triple top is not a meme
Execution Speed, OCO Orders, and the Mystery of GOOD TIL CANCEL on TOS. Please help!
3 red hot penny stocks to watch before next week—time to buy?
TIL the TV series Billions is considered fictional because it implies federal regulators are incentivized to prevent systemic financial crimes!
TIL Sometimes "safety" costs you a lot of money.
Mentions
It isn't just the biotech sector. For the past 10, almost 20 years, most corporation have trend towards downsizing or completely eliminated their R&D department in a bid to focus on the operational and business verticals. Most corporation aren't willing to underwrite R&D risk anymore. This has led to the rise and flourishing of startups that, if successful, are acquired, to be integrated into the core business of the buying company. I had a good part of my feet on the venture capital side and quant side of my professional career. **Iova is worth looking into.** They have two lines of product: Amtagvi (FDA approved for advanced melenoma with best in - class ORR, with consistency shown years after FDA approved) and Proleukin. >**52% Amtagvi Response Rate with Two or Fewer Prior Lines of Therapy 73% Overall Disease Control Rate** >SAN CARLOS, Calif., Feb. 05, 2026 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a commercial biotechnology company focused on innovating, developing, and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer, today announced data demonstrating a best-in-class profile for commercial Amtagvi^(®) (lifileucel) with unprecedented response rates in a real-world clinical, retrospective study in patients with advanced (unresectable or metastatic) melanoma. Amtagvi is the first one-time T cell therapy for a solid tumor cancer as well as the only FDA-approved treatment for advanced melanoma patients previously treated with anti-PD-1 and targeted therapy, where applicable. >The real-world results were highlighted in an [oral presentation](https://www.iovance.com/scientific-publications-presentations/) at the 2026 Tandem Meetings of the American Society for Transplantation and Cellular Therapy (ASTCT^(®)) and the Center for International Blood and Marrow Transplant Research (CIBMTR^(®)) in Salt Lake City, UT. >Forty-one evaluable patients with previously treated advanced melanoma received commercial Amtagvi according to the U.S. prescribing information at four authorized treatment centers. The physician-assessed confirmed objective response rate (ORR) was 44% (18/41) and the disease control rate was 73% (30/41). Response rates were higher with earlier Amtagvi treatment. The ORR was 52% (12/23) following two or fewer lines of therapy compared to an ORR of 33% (6/18) after three or more lines of therapy. The unprecedented real-world response rates also improved upon the 31% ORR in the C-144-01 clinical trial that supported the U.S. FDA accelerated approval of Amtagvi. >Lilit Karapetyan, MD, MS of H. Lee Moffitt Cancer Center & Research Institute stated, “The real-world response rate builds on existing clinical data and supports consideration of lifileucel as soon as possible after immune checkpoint inhibitor treatment. An overall response rate of 44% was observed in the full cohort, with a 52% response rate among patients treated in earlier lines of therapy. I am encouraged by the potential for an increasing number of patients to benefit as adoption of TIL therapy continues.” >Daniel Kirby, Chief Commercial Officer of Iovance, stated, “The real world Amtagvi data with impressive response rates, paired with unprecedented five-year durability and survival data, demonstrate a best-in-class profile and better outcomes in patients treated earlier.” >Previously treated advanced melanoma represents an unmet medical need with more than 8,000 annual U.S. deaths.^(1) More than half of patients treated with first line standard of care will progress within 12 months.^(2) The U.S. FDA granted accelerated approval for Amtagvi in February 2024 based on ORR and duration of response (DOR) from the C-144-01 clinical trial. The published [final five-year analysis](https://ascopubs.org/doi/10.1200/JCO-25-00765) demonstrated unprecedented durability and follow-up in previously treated advanced melanoma patients, with \~31% ORR, median DOR of 36+ months, and a 20% five-year overall survival.^(3) Iovance is conducting TILVANCE-301, a Phase 3 clinical trial in frontline advanced melanoma, to confirm clinical benefit. >1. National Cancer Institute Surveillance, Epidemiology and End Results (SEER) Program. 2025 Estimates. [https://seer.cancer.gov](https://seer.cancer.gov/) (accessed February 2026) 2. Larkin J, et al. NEJM; Robert C, et al. Lancet; Tawbi HA, et al. NEJM 3. Medina T, et al. JCO Source: [https://ir.iovance.com/news-releases/news-release-details/best-class-real-world-data-support-early-amtagvir-treatment](https://ir.iovance.com/news-releases/news-release-details/best-class-real-world-data-support-early-amtagvir-treatment) **Using what made Amtagvi/ lifileucel successful, Iova has made positive in-road into cell therapy for soft tissue sarcomas with a high 50% ORR.** >Iovance Announces Positive Results from the First Clinical Trial for TIL Cell Therapy in Soft Tissue Sarcomas *50% Objective Response Rate (ORR) in Advanced Sarcomas* >*Significant Market Opportunity with More than 8,000 Patients Diagnosed* *Annually in the U.S. and Europe* >SAN CARLOS, Calif., Feb. 24, 2026 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a commercial biotechnology company focused on innovating, developing, and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer, today announced positive early data from a [pilot clinical trial](https://clinicaltrials.gov/study/NCT05607095?cond=sarcoma&intr=TIL&rank=6) led by Memorial Sloan Kettering Cancer Center (MSKCC) and supported by Iovance of lifileucel in patients with advanced (metastatic or unresectable) undifferentiated pleomorphic sarcoma (UPS) or dedifferentiated liposarcoma (DDLPS) who were refractory to at least one prior line of systemic therapy. >Among the first six evaluable patients treated with lifileucel monotherapy, physician-assessed confirmed ORR by RECIST v1.1 was 50%. All evaluable patients had advanced disease, were refractory to prior therapy, and had significant disease burden, with a mean sum of diameters of 117 millimeters at baseline and a mean of more than two prior lines of therapy. Patients experienced deep responses that improved over time, consistent with lifileucel in melanoma, non-small-cell lung cancer, and other solid tumors. The safety profile was favorable and consistent with lifileucel therapy in other indications. Based on these results, Iovance plans to commence a single arm registrational trial in second-line advanced UPS and DDLPS in the second quarter of 2026 and will engage with the U.S. Food and Drug Administration (FDA) on an accelerated path to expedite approval. Iovance also plans to explore lifileucel in other high grade soft tissue sarcoma subtypes with high unmet need as part of its clinical development program. >UPS and DDLPS are high grade, aggressive soft tissue sarcomas associated with poor prognosis that impact more than 3,000 patients in the U.S. and more than 5,000 patients in Europe annually, including more than 3,500 patients with advanced disease.^(1-3) There is a high unmet medical need for new treatment options for second-line patients with recent clinical studies reporting ORRs of less than 5%, median progression-free survival (mPFS) of \~2-3 months, and median overall survival (mOS) of \~9-10 months.^(4-6) >Lauren Baker Banks, MD, PhD, Sarcoma Medical Oncologist, MSKCC, stated, “In the first clinical trial of a TIL cell therapy in UPS and DDLPS, one-time treatment with lifileucel demonstrated compelling and unprecedented response rates with the potential to address a significant unmet need in patients who are refractory to frontline standard of care. Patients with UPS and DDLPS suffer from high disease burden, poor quality of life, and a lack of effective treatments, including no approved immunotherapy options. In the second-line setting, mPFS for many patients is only a few months with mOS less than a year. We look forward to presenting these results at a medical conference in 2026.” >Dr. Brian Gastman, EVP Translational Medicine and Research at Iovance, stated, “The exciting clinical results show that lifileucel could offer a new, highly efficacious, and durable immunotherapy option in two aggressive forms of advanced sarcoma and further illustrate the promise of our TIL cell therapy platform to offer meaningful clinical benefit in multiple solid tumor cancers. Chemotherapy with extremely poor efficacy remains the second-line standard of care for these patients after progression on front-line chemotherapy. We look forward to bringing lifileucel to UPS and DDPLS patients as quickly as possible.” Source: [https://ir.iovance.com/news-releases/news-release-details/iovance-announces-positive-results-first-clinical-trial-til-cell](https://ir.iovance.com/news-releases/news-release-details/iovance-announces-positive-results-first-clinical-trial-til-cell) More: [https://ir.iovance.com/news-events/press-releases](https://ir.iovance.com/news-events/press-releases)
Humm... TIL, only 14 states have laws for mandatory programs, with 3 more states in the pipeline to mandate.
TIL Twitch streamers make more than me.
TIL there's a woman who got arrested for making an online joke about Netanyahu wtf?!
TIL xiaomi has an LLM & I follow LLM news
Wait. You can actively trade that many gains in a TFSA? TIL. Update us how tax season goes.
> you bullied his grand son TIL a bit more about Nana than was ever expected
TIL boats can die. I thought only living things could die, but my wise leader has informed me otherwise.
TIL that “up to $500 million” = billions of dollars
TIL that Japan has population of wild raccoons because people got them as pets and quickly realized that they're terrible pets. I know they're cute, but raccoons are terrible pets.
TIL ServiceNow was priced for perfection at -50% YTD.
TIL black Wednesday means +1%
TIL advanced money destroyer works in both directions
TIL what hieroglyphics is
TIL that calendar spreads can have better initial margin than just for the naked short leg.
TIL Alan Greenspan is still alive and 100 years old
Holy shit, you're right, TIL. Almost put in an order of shark skin toilet paper. What were you doing that you're touching shark cadavers? That sounds so cool
TIL its normal for women to do handstands in the womens bathroom.
TIL tacos are more powerful than steriods
TIL Wonder why people are talking about it
… TIL that putting your money into a global market fund is YOLO’ing. Wear a helmet buddy. You need one.
TIL stocks only go up
TIL being "gay" is really just a difference in ur brain that makes u like the same gender it has nothing to do with the markets
TIL none of Mag7 are software companies
TIL the OP doesn't even understand the limited blockade that is in effect.
TIL how to say reply in Polish
TIL that the Nikkei almost doubled in the last year
OP says TIL “I came to the conclusion that Tesla is the perfect example of how the market can be irrational.” This is funny. Grabbing my popcorn before I BLOCK an idiot.
No shit. TIL. We only recently started contributing to my wife’s because she started working last year… wow…
TIL doctored image means image of a doctor. Highly regarded
TIL being able to provide for your future is a cult
Or maybe this is it for cancer. They will enhance the TIL (e.g., 4001, 5001, etc.), increase efficiency, find out how to best approach it, when to provide it, decrease manufacturing costs, and maybe it will translate to a good drug. TIL is something different than most cancer drugs—a new frontier. I'm hopeful. Their results, even small, for cancers like sarcoma are incredible.
TIL America was completely finished less than a month ago, now SPY is higher than pre war. LMAO
I feel like you’re missing a lot of context bud. Yes, Amtagvi costs about ~$560k — that part is true.Yes, ~20% of patients are alive at 5 years, and median OS is ~13.9 months — also true. What’s missing is who these patients were.These were heavily pre‑treated metastatic melanoma patients who had already failed PD‑1 therapy (and BRAF/MEK when applicable). Historically, in this setting, median survival was ~6–9 months and long‑term survivors were extremely rare. Against that backdrop: A ~14‑month median OS is an improvement, not a disappointment. ~20% 5‑year survival in a PD‑1‑refractory population is unprecedented, and no chemo or targeted option shows anything close. Among responders, durable remissions lasting 3–5+ years are common, and many patients required no further therapy. Also important: median survival is a poor metric for immunotherapy. The real value of TIL therapy is the tail of the curve — patients who effectively achieve long‑term control after a one‑time treatment, not chronic dosing for years. No one is claiming Amtagvi is “the answer for all melanoma.” It’s approved as a late‑line option for patients with no good alternatives — and for a meaningful subset of them, it has genuinely been the answer.
TIL: Wee Man and Frankie Muniz are different people.
TIL: Wee Man and Frankie Muniz are different people.
TIL it is impossible to out-retard the market.
TIL people pay for Snapchat subscriptions, my how far the infidelity app has come.
TIL bears are shaped like corgis
TIL: The President cannot fire the Vice President; the only constitutional method for removal is impeachment by Congress.
TIL. we had a recession in 2020 then?
TIL Slovakia and Slovenia are two different places
TIL every Redditor is a corporate lawyer.
TIL, people still 'do their taxes'
TIL there’s a flightradar24 ship version
I think they replaced the mods with AI aka Actually Indians. Had a post the other day on TIL get 15k upvotes and then they flagged it for a confusing title but it was pretty Godamn clear. Got a broken English reply via mod mail at like 4AM that made no sense lol. I think Reddit has outsourced the mods. Timing sure made sense as I’m in EST.
TIL „I am priced in“
I didn’t know Jamal was a relative to a billionaire arms dealer til I googled if they were related. Neat. Also TIL Samira is a middle eastern name and Riot didn’t make it up for their champ name.
TIL AI can't do cigarettes properly
Very professional! I did not know that wars keep banker's hours. TIL!
TIL anomalies are measured in Celsius
TIL that a bilby is a real animal.
TIL: If you know what NATO stands for, you are overqualified to work for the New York Times.
wait, there's more information past the headlines? TIL
TIL Tiger Woods got 20+ surgeries on his right leg. No wonder he always doped up
TIL. So they are back in nuclear game because they don't want US to push them around
TIL you don’t need a PhD to go to space
TIL oil is really auto gasoline instead of oil
> shut up and color TIL "Shut up and color" is a military-originated phrase meaning to stop complaining, follow orders, and execute a task efficiently, often likened to staying within the lines. It implies a, sometimes forced, focus on immediate duties regardless of circumstances or, in corporate contexts, a dismissal of feedback to ensure compliance
TIL: Algos are completely regarded and you can bet against them all the time using common sense.
TIL Barbara Feldon (Agent 99) is still alive at 93 - she's close to dat number lol
TIL Trump caused the Strait of Hormuz to close just to distract from the Epstein files.
TIL that Vietnam war lasted 20 years. God damn
TIL that stagflation can be mild. Markets can still pump HAHAHAH
TIL jeff bezoz doesn't let you buy from his secret black Q stickers stash 😤
TIL the US doesn't do oversize novelty chocolate eggs for easter. Guys... Really?
TIL Iran means land of the aryans.
TIL that the eggs, bunnies and springtime themes of Easter are actually rooted in pagan spring fertility festivals.
TIL Lindsey Graham is a boi
TIL Robinhood only lets you withdraw 50k per business day. It’s going to take me 4 days to withdraw the 190k i made T_T
TIL morgan stanley is more regarded than me
TIL if you fuck shit up, shit gets fucked up
TIL, Australia is Asian! Konnichiwa, ya cunt!
TIL words don't mean anything
TIL I have pneumonia for 3 years