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CRSP - big news coming … life changing medical breakthroughs for Sickle Cell Disease and Beta thalassemia that offer CURES not treatments
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Most, if not all, gene-therapy companies are booming today. Good sign for future of CRISPR/CAS9 stocks, etc.
I constantly give Gemini and GPT random tasks just slightly above "summarize three paragraphs into one" and it is staggeringly bad how it just lies to your face. Recent example: "My solution of chemical CAS: XYZ is not freezing at -70C any suggestions to to why?" Reasonable answer(s): - It isn't the chemical you think it is. - There are impurities or contaminants - Your probe/equipment is wrong (not -70C) What did they do? Tell me thats completely normal because -70 is a smaller number than the -50 it freezes at, gave me a fake graph showing this phenomenon and said everything checks out because thats following THE LAWS OF PHYSICS. Meanwhile tech CEOs out here saying these things are getting to "PhD Responses". Bruh it literally didn't catch which side of the freezing point it was on, and then made up the backstory to why this all makes sense. I have so fucking many examples. Literally trying to see what it can do that isn't creative (no real answer to be bound to) or summarization; and it fucking sucks everytime. WTF
Marcus! Currently 3.90% with my referral - marcus.com /share/CAS-73C-KJ9Z
Let’s see it is August AN ALL DEEZ WHIPIPO CAS ALL DA PROBLUMS AN IT DEY FALT AN TRUMP FALT DA EBT AN FOOD STAMPS BE CUT DAS SUM BOOOSHIIIII
I agree with you there, and I’m not adding capital - I’ve frozen my long term holds, aside from trades of swapping in/out and some option moves with the CAS tickers. I have no doubt that in the unlikely event a big catalyst actually happens, safe, or rescheduling, even the shittiest of stocks will rally hard on the initial pop - all of them will. But the Greenthumbs will be steady and probably continue a slow and gradual increase where the risky high debt guys will probably peel off once the shorts and the initial meme rally fades. Happy weekend all, let’s hope for something big to happen next week!
Again, wrong. ViaCyte/Vertex had been developing their solution since prior to Sana being founded. Crispr also partnered with ViaCyte a half decade prior to Sana being founded, from which point they were concurrently developing multiple treatments which are incremental in progression. Their naked cell development predates Sana, including CTX213. Also the Sana hypoimmune platform and the Crispr CAS9/CAS12 platforms are distinct from one another, working in different manners, with some overlap with CAS9/CAS12 use in their platform. The Crispr treatment is based on direct gene editing, which is something they have done successfully from pre-clinical to market, whereas Sana is working on immune cloaking and is in early pre-clinical. The user of Crispr technology is proven and has long term safety data to back it up, while the Sana hypoimmune tech is experimental and not necessarily any more advanced than Crispr. Additionally this again misses the fact that CTX213 has underlying research and a lot more data, including going back to VCTX210 (precursor to CTX213), while Sana is just starting preclinical on a scalable solution to match. Both solutions also have risks, with Crispr having the worry of off target effects (a major reason why a device assisted option holds so much promise, especially with the incremental revisions to work out the device kinks) while Sana holds risks with long term persistence and risks from immune invisibility (a lesser worry with CAS9/12 alone since they aren't meant to be invisible). That is also ignoring the risks that Sana has from donor cell variability which is something that Crispr completely eliminates, due to the same reasons why one of these is scalable and the other isn't.
Incorrect, as a t1d I have been following these closely and the ViaCtye/Vertex partnership + trials. Crispr is ahead of Sana, by years in research and financials. Sana is pumping out hype to drive investment and pump their stock, whereas Crispr is not in a rush to release info about their clinical trials. The solution they are working on are different, Crispr is using CAS9 gene editing while Sana is working on a hypoimmune gene editing solution, there is not significant overlap much less anything that would be a patent issue. Crispr is ahead with their device assisted option which is what the T1 community would most look forward to and which would come with less of the long term question marks that a deviceless treatment would come with. The same solution is also moving into clinical trials with Crispr, while Sana isn't all that much further ahead with a single patient clinical trial that is deliberately stacked in their favour (the forearm muscles are less likely to elicit a quick reaction than fat or organ tissue). CTX213 with the work already done one CTX211 will quickly overtake UP241. Additionally, the solution that Sana is developing is not mass scalable while the solution Crispr is developing will be limited only by the size of investment into standardised manufacturing.
See aboce; this is base editing, not CAS. BEAM
This is base editing, not CAS9; BEAM is the base editor, not EDIT
I'm literally a biologist [https://scholar.google.com/scholar?as\_ylo=2025&q=CRISPR/CAS9&hl=en&as\_sdt=0,15](https://scholar.google.com/scholar?as_ylo=2025&q=CRISPR/CAS9&hl=en&as_sdt=0,15)
I mean CAS is a $4b market in the US, so not super niche. The only niche part is that we take waste from semi conductors, but that’s a major problem for them. LAS waste cant be stored, and Intel for example just in Phoenix, produces 3,500 tons a quarter, out of one fab.
Not from us. We take a domestic waste, and sell it to domestic farmers. 90% of the United States supply of CAS has historically come from China.
As a Wolfspeed customer of their CAS480s for the last 4 years, I fully agree.
Quantum can be a good long term based on the fact that it will probably have an insane boom like AI now (prob smaller though) in 10+ years. The first 3 you mentioned are probably dead by then. They are behind the competition in their tech and partially got a somewhat scammy leadership. The leader in the space atm are Google, IBM, Quantinuum (not public) and CAS (not public). So its hard to get a great exposure to it.
Most public ones are currently overvalued and in kinda a bubble while being effectively out of the race to be the best (I'm talking Ionq, rigetti etc). Leaders are IBM, Google, quantinuum (private) and maybe CAS(private). If you asked 6-12 months ago you could have made some nice money. Now they only print in the opposite direction.
That is completely false. Crispr CAS9 is gen 3. They are the most advanced in the space. I work in utilities. I know the SMR thing. Good idea, long ways off. I'm staying clear of the hype names in that space.
You are think of a technique. Crisper-CAS9 that Doudna sort of discovered( MIT sued Berkeley because it happened simultaneously). The company is trying to find applications for inserting a specific thing into a human and showing result as a therapy. So far it is as promising as wet dirt Kurt’s hotdogs. Just cause you can insert something doesn’t mean you get the desired results. 😳🌭😅
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Clifford A. Sosin is the founder and investment manager of CAS Investment Partners. LLC ("CAS"), which he launched in October 2012. Immediately prior to founding CAS, Mr. Sosin was a Director in the Fundamental Investment Group of UBS for five years where he was a senior member of a team analyzing equities and fixed income securities. Prior to UBS, Mr. Sosin was employed as an analyst by Silver Point Capital, a hedge fund which invested in high yield and distressed opportunities, as well as by Houlihan Lokey Howard & Zukin, a leading investment bank best known for its advisory services with respect to companies requiring financial restructuring. Mr. Sosin earned both a B.S. in Engineering (High Honors) and a B.A, in Economics from Swarthmore College. ​ [Source](https://www.casinvestmentpartners.com/about-us.php)
OCA Omnichannel Acquisition Corp and CAS Cascade Acquisition Corp
[Cascade Acquisition Corp. Announces Liquidation](https://www.globenewswire.com/news-release/2022/05/18/2446456/0/en/Cascade-Acquisition-Corp-Announces-Liquidation.html) \- CAS CAS.WS
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Check out this CAS hedge fund w 43% ytd loss. It had 25% in cvna!
PWC China doesn’t use US GAAP…they use CCP CAS. Businesses operating in China are required to follow the Chinese Accounting Standards (CAS), also known as the Chinese Generally Accepted Accounting Principles. CCP data is bullshit =
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Bro Ukraine is nothing like Iraq. Iraq was won at the “highway of death” where the majority of the Iraqi armored corps was wiped out in a few CAS sorties. Ukraine is going more like the winter war in Finland. Russia can indeed push its forces where it wants to. But it’s forces and supply lines are literally bleeding. Instead of Finnish snipers it’s Ukrainian javelins and stingers.
That's coming. The Chinese GAAP, or CAS more correctly, are often a tangled web of bullshit when you hit the Chinese subsidiaries. The FIEs are not going to be getting passes much longer. And downvoting me for my opinion and honest response is childish.
Moderna is already into gene editing via CRISPR. They plan to design therapeutics that deliver CRISPR/CAS-9 via encoded mRNA lipid nanoparticles to completely cure genetic diseases
3 SOA if he goes that route, 2 CAS
I can't speak too much on it from a business perspective but as a PhD candidate I can say that its use is becoming increasingly prevalent, and moreover the base CRISPR/CAS9 technology has been able to be adapted for different uses than the traditional gene editing approach. I believe the technology will become as ubiquitous as things like PCR but the difference is the technology is more or less monopolized currently leaving an incredibly large amount of growth on the table. However it is a biomedical company and we all know how often those stagnate or bankrupt so, you know, take this with a grain of salt. I am personally long on CRSP and have a small holding that I have been DCA'ing through this extended dip
Define speed, it can have all the MHz in the world, if the CAS latency is high it does not really matter, someone I had the same convo with on here previously said the low end was 5800MHz, at that speed I think CL 22 would be a wash compared to 3000MHz CL 16, I would have to find the formula again, regardless this is why I said without a real world spec sheet it means nothing.
>So you seem to agree that the economy is a CAS, but now you are claiming that inflation is definitely transitory. Maybe it is, maybe it isn't. How do you know? Especially given the fact that, as you said, this is an extremely complicated situation which we've never experienced before. I admit I could be wrong. To clarify that by "transitory inflation" I, and most others talking about it, actually mean "transitory rate of inflation increases". I expect rate of inflation to look between 2 and 2.5 over a decade that includes 2020/2021. The reason I'm so confident is that the the reasons for the current rate of inflation are fairly obvious right now, and they are all transitory themselves. The used car situation is based almost entirely on the total lack of fleet car purchases, something that will almost certainly not occur again. And this is one of the largest contributors to the inflation rate increase. Other causes include the container problem and the supply chain issues caused by the pandemic. It might take a while to sort these out, but they *will* be sorted out, which will drive shipping costs back down, removing this from the calculation. I don't see any specific structural reasons that would lead to a long term 5% rate of inflation for instance. The discussion on this topic has been driven by dramatic YOY and MOM increases, but YOY comparisons are useless because of base effects (take the 2019-2021 rate and average it over 2 years, and you'll see what I mean) and MOM effects are distorted by reopening effects. >I don't live in the US and am aware that the pandemic is not over. As for them missing the data, one would expect them to miss sometimes on the downside, rather than consistently on the upside IMO. I did not actually say you were from the US! Because the conversation on this board has been driven by large increases in the US rate of inflation and because rate of inflation increases were less pronounced in Europe and Canada it seemed a reasonable assumption that we were discussing the US economy. In my opinion the reason they have consistently missed on the downside is because they don't like what their numbers are telling them so adjusted down, and because they did not anticipate how frothy the used car and construction markets would get, and because analysts continue to underestimate the appetite from people to spend money after being constrained for so long.
>I love that you specify that the economy should be looked at as a CAS (it should) and then completely ignore that for the rest of your post, basing the entire bear thesis on traditional measures and ignoring events that have amplified or dampened these measures. No, I don't think my entire thesis was based on that part. I think the bulk of it, actually, was based on William White's work. >Inflation is transitory because the conditions that are driving it are transitory. Supply chain issues will even out, the container problem will be resolved, and used cars (which are driving a frankly ridiculous portion of the inflation increase) will become available again causing price increases to settle down. Unless you believe that used cars will stay as scarce as now, and that transport issues won't be resolved, then you think that inflation will not continue at its present rate even if you don't realize it. I Inflation was around 0% last years. Because it compounds, to stay on the 10 year trend line it would have to be around 6% for the year, which seems unlikely at this point. So you seem to agree that the economy is a CAS, but now you are claiming that inflation is definitely transitory. Maybe it is, maybe it isn't. How do you know? Especially given the fact that, as you said, this is an extremely complicated situation which we've never experienced before. I don't live in the US and am aware that the pandemic is not over. As for them missing the data, one would expect them to miss sometimes on the downside, rather than consistently on the upside IMO.
I love that you specify that the economy should be looked at as a CAS (it should) and then *completely ignore that* for the rest of your post, basing the entire bear thesis on traditional measures and ignoring events that have amplified or dampened these measures. Predictions are miles off at the moment precisely because we've never come from a global pandemic before. The recovery is uneven and impacted by government doing what it *should* be doing, which is looking out for it's citizens in a time where through no fault of their own they cannot look after themselves. Employment rocketed up over the last few months but the US economy had been exploiting the shit out of minimum wage workers who have suddenly realized that they don't have to take it anymore. Jobs with reasonable pay have, by and large, not had any problems being filled. As an investor this should excite you - more liquidity in the hands of people likely to spend it has, and will continue to, boost the economy creating opportunities all over. Inflation is *transitory* because the conditions that are driving it are *transitory*. Supply chain issues will even out, the container problem will be resolved, and used cars (which are driving a frankly ridiculous portion of the inflation increase) will become available again causing price increases to settle down. Unless you believe that used cars will stay as scarce as now, and that transport issues won't be resolved, then you think that inflation will not continue at its present rate even if you don't realize it. I Inflation was around 0% last years. Because it compounds, to stay on the 10 year trend line it would have to be around 6% for the year, which seems unlikely at this point. >Bernanke would also claim that the crisis was nothing more than old-fashioned financial panic, and that if not for the panic it would have been the equivalent of merely "a bad day in the stock market". Bernanke's mistake is to ignore the actions on Wall Street in all this. The subprime mortgage fiasco was a complete mess but escalated into a disaster because of a targeted attack by short sellers on Bear Stearns and Lehmans, which caused Lehmans to collapse, which caused a panic. (This is something of an aside but I wanted to put it out there). I don't disagree with much of your "where we are today", but I did feel that you missed a trick talking about the indicators. I know the US loves to believe that the pandemic is over and everyone overreacted anyway, but it is still having a deep impact on the world economy and may of the problems it caused are not solved - for instance everything shut down in early 2020 so all the rental companies offloaded their rental stock, planning to buy when things reopened but they are the largest supplier of used cars to the market so because they did not buy new cars in 2020, there was no supply in 2021 causing a massive spike in used car prices. Another example is that containers are stuck in depots because they were not shipped back in early 2020, leading to a container shortage in the supply companies and causing rates for containers to spike. 10x normal container prices won't last forever, and neither will rental companies not selling cars into the used market. People will go back to work as the market adjusts to new minimum requirements for labour rates. Mind you, the danger now is that we *really* run into a bubble and have a 2029 crash....
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I work with CRISPR CAS 9 in the lab I intern in. The stocks are to risky for me but its awesome to see this in work
This is just CRISPR CAS9 gene editing, I intern in a lab thats working with CRISPR gene editing, cool stuff
Introducing new SDR5 RAM! It’s got a 6 CAS latency that will bring Ayour GAMING TO XTREMWb n!!!! It will improve your reaction speeds by 0.007% 😎😎😎😎 Welcome to the REVO-YOU-TION POWER TO THE GRAMWR!!!
To cite LMT: "We expect a total net FAS/CAS pension benefit of approximately $2.3 billion in 2021 based on a 2.50% discount rate (a 75 basis point decrease from the end of 2019), an approximate 16.5% return on plan assets in 2020, and a 7.00% expected long-term rate of return on plan assets in future years, among other assumptions. We expect to make contributions of approximately $1.0 billion to our qualified defined benefit pension plans in 2021 and anticipate recovering approximately $2.1 billion of CAS pension cost. " Meaning they have pension obligations (for ex-staff) of 51b, covered by assets/equity worth 38b, meaning their pension obligations are underfunded by 13b. (This was in February). If equity markets drop, those underfunded 13b could become something like 40b underfunded, while pension obligations stay the same, which then would have to be covered by their cashflow, damaging their balance sheet massively.
Addition to Russell 2000 announced early june. Addition to telco ETFs probable. Launch peovider deals for the BB1 sats. New mou / deals with telco:s Technology maturity / test results info / performance data mught also be published. Permitting of different sortd may be announced. Launch date on the CAS-500-2 rideshare for BW-3
Addition to Russell 2000 announced early june. Addition to telco ETFs probable. Launch peovider deals for the BB1 sats. New mou / deals with telco:s Technology maturity / test results info / performance data mught also be published. Permitting of different sortd may be announced. Launch date on the CAS-500-2 rideshare for BW-3 Gov Grants for 5g rural connectivity, maybe.
Honestly with low liquidity price fluctuations it changes on a daily basis and is also relative to price tier. I also have like 50 positions so I'm more spread out instead of concentrated and sell out of positions I like on pops to buy something else I like dipping. My biggest positions are PACXW, TACA-WT, PGRWW, CFFVW, CAS-WT, DLCA-WT, KINZ-WT, KWAC-WT (Lombard International rumor, in the .50s) and NVSAW.
There were papers saying the CAS9 CRISPR system can cause cancer. How does this impact edit?
EAGB, a Canadian version of ARKK. In my opinion, CRISPR/CAS-9 will be a significant game changer in terms of medicine in the future. We're in the early stages and I invest in that ETF from time to time hoping in the long run it will pay. Sadly, I found out about it after it went up at the beginning of the pandemic.
NO the CRISPR CAS9 gene editing technique is NOT patented - but any PRODUCT can be patented. Maybe you can patent the production of a type of magnet, but you can't patent magnetism any more than you can patent a carbon molecule or a naturally occurring bacteria or the human digestive tract. Novel organisms that you engineer can be patented. GM crops for instance.
Pro-tip from a guy with two biomedical degrees - don't bother reading comments on a medical technology thread. They're always full of overstated claims from underinformed individuals. CRISPR-CAS9 is certainly the discovery of the decade (technically last decade), but it's a major improvement rather than a new field. It's the invention of the printing press, not the invention of the language.
TLDR: EDIT, CRSP, and NTLA are founded by a group of scientists who discovered CAS-9 technology; this technology has the ability to “extract” parts of defective DNA and replace it with a working ones...that’s right....the implications are to eradicate incurable diseases. I’m not tracking on the specifics of EDIT, but I know that the technology isn’t where it needs to be to give to humans. It’s not “targeted” enough and could potentially splice the wrong genes.
I used to work with CRISPR CAS9 at my old lab, that shit is mega cool
A pair of scissors don’t make a bonsai master. CRISPR\CAS9 is at the stage where Lentiviral vectors were in the 80s. Genomics are a lot more advanced, so it won’t take 40 years, but yeah, it will take some time and there will be a lot of setbacks.
BZ from a “chair force”E7 (spent my whole career deployed) and knows what it took to write those words, and has faced similar challenges once the CAS stops...
most of my Gme, 57 shares, is with Fidelity. I had a few stocks left in RH including 6 shares of GME. I initiated transfer. In the transfer tracking area of Fidelity it lists all the stocks being transferred EXCEPT GME. They were bought with settled cash, not margin. What gives with RH? Were they really only selling us IOUs? [https://imgur.com/gallery/BP4CAS4](https://imgur.com/gallery/BP4CAS4)
I wasn't gonna say it, but I'll upvote and agree with you. I honestly don't see what this site is showing that dozens of other free sites (let alone my own visualization tool) don't already show better. It looks like a thinly veiled advertisement for a wannabe financial consulting firm. "ONLY platform that can derive the risk neutral density for ALL retail traders." Really? The only one? Me and my MATLAB disagree. Also, it's 2021, I'm not impressed with simple 2d plots anyone can make with a CAS. More impressive would be to show the volatility surface, or *any* surface plot, allowing the user to choose the axis. Also if it would spit out numerical values for local maxima/minima on the plot.
CAS19 aka crispr bio-tech will be the next big thing, ever. for those who develope enhancements and bio science early on. think about this, the CAS19/crispr bio-science will allow the developer to END organ transplant requirements. no more issues with genetic manipulation to fix inherited family genes that could potentaly cause a plethora of early life termination. the world could be looking at the fact of ending genetic pre-disosition of organ failure, diabetis..you name it. the question is WHO is going to get it right. as of now, the chinese are WAY ahead of the game and BAYER is next in developement. the crazy thing is that its now anybodys game, from big pharma to government involvement. obviously its prudent to follow bio-science tech news and where the $ goes
It’s true that they don’t follow GAAP however when preparing annual financial reports, all FIEs are required to follow the Chinese Generally Accepted Accounting Principles (GAAP), also known as Chinese Accounting Standards (CAS). The CAS framework is based on two standards: Accounting Standards for Business Enterprises (ASBEs); and Accounting Standards for Small Business Enterprises (ASSBEs). The Ministry of Finance (MOF) released ASBEs in 2006 and brought them into effect in January 2007. It is widely viewed by the international community that ASBEs are now substantially converged with IFRS.
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As with all my stock decisions- there’s only a portion of rationale there... Chewy- I upped my routine order, so figured I’d earn back my increased spending. It’s a mid to long hold for me CRSP- been watching the price drop, all most pulled the trigger but took a nap instead to wake up and see that I SHOULD have bought. So on Monday I will snatch it up. I learned of CRISPER/CAS-9 a few years back and have been obsessed since. IF they fine-tune their science and get past the ethics committees, they’re the next generation of modern medicine.
For a primer behind the CRISPR-CAS9 tech that normal humans (non scientists) can absorb readily I recommend Radiolab’s episodes. When I first heard about this I was like 🤯 https://www.wnycstudios.org/podcasts/radiolab/articles/antibodies-part-1-crispr And their follow up: https://www.wnycstudios.org/podcasts/radiolab/articles/update-crispr If I had money to throw into investments I’d be right there with you. This is some next level stuff and I think it will prove to be the way forward for a lot of genetic fixes for diseases and other issues.
Well, that analogy does compare the cas-9 system CRSP uses. By no means does a butter knife not do the job it's just not as precise and detailed as BEAM. There are 4 bases in DNA, BEAM can cut through all 4 seamlessly while CRSP has to refine their process for 2 of them and run the other 2 well. ARKG has dropped their holdings recently but that doesn't mean CRSP can't come out with a better and more elite CAS system and toss everyone under the radar and moon their stock. However, for all thing certain BEAM is the future.
I got in to CRSP about 4 years ago, thanks to a podcast called "[This Week in Science"](https://www.twis.org/) which reviews recent research across a broad spectrum of scientific inquiry every week. Literally every week they were discussing some new awesome research results from CRISPR CAS9. This was before CRSP's research leads won Nobel prizes. The results of their research were so good, and so clearly revolutionary, that I had to buy in. The potential is staggering. I'm at 3x on the position now. A few weeks ago it was higher (closer to 6-7x), but then we had the recent chill on the market.
FELLOW SMALL FRYS https://imgur.com/a/CAS1Gao LET US HOLD TO THE MOON