Reddit Posts
Evemon problems with ESI Token
$ESI - healthy (penny) stock that keeps giving.
Recent stock transactions by US congressmen alongside trade returns
Good opportunity today to invest on $ESI after the pull-back
ESI :a TSX PLAY with the energy sector in Canada
$ESI-The great value semiconductor play you've never heard of 🚀🚀🚀🚀🚀
Mentions
How are you looking? I think there is always some value in the market, you just need to actually look. For me screening has been great in terms of research and finding companies are a reasonable value. For example, I called out ESI here a few weeks ago. I’m up like 25% on that. Same thing with KN.
I don't think so, but to each their own. I just choose to do research and buy stuff that makes sense, which is what most people don't actually do with investing. Some of the names I've called out here over the past few weeks have been killing it. ESI is up 5.6% today. KN is up 3%, CTS is up 2.7%. A few names that aren't junk by any means beating the market.
I'm gearing up for HONA as well. It'll be my next position I'm targeting. I wasn't planning on MANH and DSGX but I think they are both viable opportunities and I'm taking profits when I can on this market as long as it makes sense to exit a position. I was planning on holding both long term but it is what it is. SOLS is a regret in hindsight. They IPO'd just before Qnity Electronics did but I didn't even hear about them. Q has been one my best performers so far, but man SOLV isn't chump change either. Recently sold my PL after their last earnings and got into ESI as well.
Oh I view the show and him and infotainment. Like I was going to buy regardless, it's just fun to call lol. The problem with being on TV everyday is having to have takes and make content. Like I haven't really found anything too new or interesting since like CTS, KN, and ESI. I'd be terrible if I had to put out daily content.
To each their own, but I don't always kind Cramer the kiss of death. I called the show about ESI a few weeks ago, he ended up doing a segment and the stock has still been doing great since then.
I posted about a few names like I bought some CTS, KN, and ESI recently. Been focusing on names that deal with components around like RF frequencies and things that will get you exposure to aerospace and defense.
Overall market is pretty tiny, part of why there hasn't been a ton of investment in the first place. Odd lots has a great podcast with someone does helium, it's pretty interesting. I called out ESI here a few weeks ago, that's how I'm playing that.
Yep! Yeah, IESC is another, you're pretty much one of the few people that would ever actually respond to my posts. I'm a big believer of that too. Like there's always something you can find in the market. It's nothing crazy yet, but my ESI position is up like 20% since I brought it up. That's 2x expected returns of the market in a short period of time.
ESI and KN are two of the names I put some capital to work.
ESI, Israeli index etf, +60% last year, + 6% YTD
Post more in thr daily, but bought some ESI a week or two ago. It’s my play on the space. It’s a small/mid cap company that is trying to transform a bit. Sold off older less margin business and acquired two new companies recently. One is around gasee and the semi conductor industry. https://ir.elementsolutionsinc.com/Investors/news/news-details/2025/Element-Solutions-Inc-Announces-Agreement-to-Acquire-EFC-Gases--Advanced-Materials/default.aspx
Been the common theme of a few my buys recently, like ESI and CTS. I like these really niche/unknown industrial plays, especially when they have tailwinds. Like KN are used in aerospace/defense, especially satellites, and like EVs and battery storage. It's good a lot of good tailwinds.
I saw there’s a new odd lots podcast on it. Going to listen to it later today. Brought up ESI as an interesting name a few weeks ago. They recently acquired EFC gases which gives ESI exposure to helium as well as closed loop recycling.
Oil companies are not gold companies. Large caps are not small caps. There is no comparison here. Oil companies don't even trade on book value. Having a P/B of less than one means that the market is pricing ESI for underperformance. Their revenue, fcf and ebitda have been flat for 4+ years.
I post more in the daily, since I screen a ton and love talking about companies. I'm a GARP investor who likes a lot of stuff that is more under the radar in general. ESI Fundamentals aren't the worst, but waiting for that pull back [https://stockanalysis.com/stocks/esi/statistics/](https://stockanalysis.com/stocks/esi/statistics/) Biggest thing is that they acquired two new companies this year, so it's basically spiked their debt and they are hoping to deleverage a bit by the end of the year. Basically company is moving away from lower margin business and moving into higher margin stuff. Also some insider selling, which isn't great, but I don't always view that as the biggest red flag personally. Description of that they do: > > > Here's the latest investor presentation from earning: [https://s201.q4cdn.com/946831106/files/doc\_financials/2025/q4/V2/4Q-2025-Earnings-Deck-vF.pdf](https://s201.q4cdn.com/946831106/files/doc_financials/2025/q4/V2/4Q-2025-Earnings-Deck-vF.pdf) BSY A cool little niche software name. Debt looks kind of bad, but they did it via convertible notes and it was for acquisitions to make them even more niche for civil engineering design. Fundamentals [https://finviz.com/quote.ashx?t=BSY&p=d](https://finviz.com/quote.ashx?t=BSY&p=d) For someone that is long on the infrastructure spending, this is a great little layer to put on top of the trade that is a different industry. The iTwin technology is really rad and it's really sticky product too. It does real world modeling around infrastructure projects. It also stores the history of all the changes, so it makes it really hard to switch. Plus the regulatory stuff around it adds a little moat. The have a rad little intro to the company slide deck [https://www.bentley.com/wp-content/uploads/bsy-introduction-to-bentley.pdf](https://www.bentley.com/wp-content/uploads/bsy-introduction-to-bentley.pdf) Also little bonus, pays a little dividend.
Right on, always do that too! I'm by no means an expert, but love to always share anything I find that seems interesting. I think last one I called out was ESI and that's having a great day today. Actually called madmoney about recently and I think Cramer will end up doing a segment on it.
Always wild how some names can move sometimes. FTK was down like 10% and now it's up like 1.22%, what a swing lol. Did a tiny order on ESI, hoping it keeps dipping to increase my position.
It's fun to vote! It's funny because I'll go against more board compensation, but always for any board members and audit's lol. Fidelity has cash in SPAXX by default, so it's sitting there, just need ESI to fall like 10-15% lol.
Well this could be a good candidate for what I'm doing. Trimmed half my PL shares premarket and after earnings may sell out completely and lump sum that half into something new. Would love some exposure to space again, but want to take profits with this short volatility. Q is moving more industrial but definitely more pure play on semis than ESI.
Put in a limit order for this company at 27.75 today. Hopefully it will hit one of these days, but really interesting company, ESI. Fundamentals aren't the worst, but waiting for that pull back [https://stockanalysis.com/stocks/esi/statistics/](https://stockanalysis.com/stocks/esi/statistics/) Biggest thing is that they acquired two new companies this year, so it's basically spiked their debt and they are hoping to deleverage a bit by the end of the year. Basically company is moving away from lower margin business and moving into higher margin stuff. Also some insider selling, which isn't great, but I don't always view that as the biggest red flag personally. Description of that they do: >The company operates in two segments: MacDermid Alpha Electronics Solutions and Element Specialties. Its MacDermid Alpha Electronics Solutions segment provides assembly solutions, including surface mount technologies, pastes fluxes, thermal management materials, coatings, and other attachment materials; circuitry solutions, such as circuit board metallization, circuit formation products, electronic materials, surface finishes, and film and smart surface solutions; and semiconductor solutions, which includes semiconductor assembly and wafer level packaging materials. >This segment serves the mobile communications, computers, automobiles, and aerospace equipment industries. >The Element Specialties segment offers industrial solutions, including electroless nickel, plating products, pre-treatment and cleaning solutions, functional conversion coatings, and water treatment; and energy solutions, which includes offshore fluids. Here's the latest investor presentation from earning: [https://s201.q4cdn.com/946831106/files/doc\_financials/2025/q4/V2/4Q-2025-Earnings-Deck-vF.pdf](https://s201.q4cdn.com/946831106/files/doc_financials/2025/q4/V2/4Q-2025-Earnings-Deck-vF.pdf)
$PLTR In case you forgot, here's a reminder of what Palantir is capable of -Heineken: "What took us three years before, the team built in just three months" -Citi Wealth: “This process would take 9 days. Now it takes seconds.”Citi has achieved a 90% decrease in time per case and an 80% cut down on handoffs, all while retaining the quality of their work. -General Mills: We’re saving on average about $40,000 a day, which is about $14M ANNUALLY– and it’s really only deployed to part of our network." -Fannie Mae: "It was a mortgage case fraud case... There's a lot of paper--reams of paper. It took our really talented investigators 60 days to detect fraud into these files. It took your technology 10 seconds, like holy cow." -Morson Group: 53% faster in finding x3 candidates. 1hr 8min average per consultant. 129% increase in placements made -Applied Materials: 24-month projects to 6 weeks. "We have big consulting companies coming in. We can do this in 24 months, it's going to be millions of dollars. With Palantir, we solved this in 6 weeks on the pilot just by connecting to those Legacy systems." -Walgreens increased the operational efficiency by 30% -Nebraska Medicine increased patient discharge speed by 2000% paired with a 95% discharge prediction accuracy -AIG reduced a four-week underwriting time to less than one day. -TeleTracking reduced 24-hour manual healthcare process to seconds -Bolt reduced checkout cancellations to 50% -U.S. Department of State can reduce the time it takes to clear candidates to the Foreign Service from 60 days down to 12 -HyperScienceAI and ManifestCyber reduced the FedRamp costs by 10x and its audit time by 94% -Walgreens increased its operational efficiency by 30% BP reduced costs per barrel by 60% Tampa -Hospital improved its nurse staffing ratio attainment by 30% Cleveland Clinic reduced its bed capacity calculation time by 75%, 38 Minute decrease in ER wait time and 40% Reduction in unused orthopaedic OR time -Paraxel reduced the Clinical Submission Readiness Time by 50% Morson group reduced x3 candidate search time by 53% -Airbus accelerated A350 production by 33% -Tyson Foods achieved $200 million in cost savings -@USArmy recovered $2B in unliquidated funds -@DeptVetAffairs saved $92M+ in funds -World Food Programme saved $30M in delivery costs -Jacobs Connect cut power usage by 30% -Panasonic decreased waste by 12% ESI Group sped up ERP harmonization by 70% -Panasonic Energy cut the 3-6 month learning curve down to just a few weeks for veteran technicians -PG&E reduced transformer ignitions by 65% -Eaton boosted productivity by 25%
Copied but a nice summary I read -Heineken: "What took us three years before, the team built in just three months" -Citi Wealth: “This process would take 9 days. Now it takes seconds.”Citi has achieved a 90% decrease in time per case and an 80% cut down on handoffs, all while retaining the quality of their work. -General Mills: We’re saving on average about $40,000 a day, which is about $14M ANNUALLY– and it’s really only deployed to part of our network." -Fannie Mae: "It was a mortgage case fraud case... There's a lot of paper--reams of paper. It took our really talented investigators 60 days to detect fraud into these files. It took your technology 10 seconds, like holy cow." -Morson Group: 53% faster in finding x3 candidates. 1hr 8min average per consultant. 129% increase in placements made -Applied Materials: 24-month projects to 6 weeks. "We have big consulting companies coming in. We can do this in 24 months, it's going to be millions of dollars. With Palantir, we solved this in 6 weeks on the pilot just by connecting to those Legacy systems." -Walgreens increased the operational efficiency by 30% -Nebraska Medicine increased patient discharge speed by 2000% paired with a 95% discharge prediction accuracy -AIG reduced a four-week underwriting time to less than one day. -TeleTracking reduced 24-hour manual healthcare process to seconds -Bolt reduced checkout cancellations to 50% -U.S. Department of State can reduce the time it takes to clear candidates to the Foreign Service from 60 days down to 12 -HyperScienceAI and ManifestCyber reduced the FedRamp costs by 10x and its audit time by 94% -Walgreens increased its operational efficiency by 30% BP reduced costs per barrel by 60% Tampa -Hospital improved its nurse staffing ratio attainment by 30% Cleveland Clinic reduced its bed capacity calculation time by 75%, 38 Minute decrease in ER wait time and 40% Reduction in unused orthopaedic OR time -Paraxel reduced the Clinical Submission Readiness Time by 50% Morson group reduced x3 candidate search time by 53% -Airbus accelerated A350 production by 33% -Tyson Foods achieved $200 million in cost savings -@USArmy recovered $2B in unliquidated funds -@DeptVetAffairs saved $92M+ in funds -World Food Programme saved $30M in delivery costs -Jacobs Connect cut power usage by 30% -Panasonic decreased waste by 12% ESI Group sped up ERP harmonization by 70% -Panasonic Energy cut the 3-6 month learning curve down to just a few weeks for veteran technicians -PG&E reduced transformer ignitions by 65% -Eaton boosted productivity by 25%
$PLTR In case you forgot, here's a reminder of what Palantir is capable of -Heineken: "What took us three years before, the team built in just three months" -Citi Wealth: “This process would take 9 days. Now it takes seconds.”Citi has achieved a 90% decrease in time per case and an 80% cut down on handoffs, all while retaining the quality of their work. -General Mills: We’re saving on average about $40,000 a day, which is about $14M ANNUALLY– and it’s really only deployed to part of our network." -Fannie Mae: "It was a mortgage case fraud case... There's a lot of paper--reams of paper. It took our really talented investigators 60 days to detect fraud into these files. It took your technology 10 seconds, like holy cow." -Morson Group: 53% faster in finding x3 candidates. 1hr 8min average per consultant. 129% increase in placements made -Applied Materials: 24-month projects to 6 weeks. "We have big consulting companies coming in. We can do this in 24 months, it's going to be millions of dollars. With Palantir, we solved this in 6 weeks on the pilot just by connecting to those Legacy systems." -Walgreens increased the operational efficiency by 30% -Nebraska Medicine increased patient discharge speed by 2000% paired with a 95% discharge prediction accuracy -AIG reduced a four-week underwriting time to less than one day. -TeleTracking reduced 24-hour manual healthcare process to seconds -Bolt reduced checkout cancellations to 50% -U.S. Department of State can reduce the time it takes to clear candidates to the Foreign Service from 60 days down to 12 -HyperScienceAI and ManifestCyber reduced the FedRamp costs by 10x and its audit time by 94% -Walgreens increased its operational efficiency by 30% BP reduced costs per barrel by 60% Tampa -Hospital improved its nurse staffing ratio attainment by 30% Cleveland Clinic reduced its bed capacity calculation time by 75%, 38 Minute decrease in ER wait time and 40% Reduction in unused orthopaedic OR time -Paraxel reduced the Clinical Submission Readiness Time by 50% Morson group reduced x3 candidate search time by 53% -Airbus accelerated A350 production by 33% -Tyson Foods achieved $200 million in cost savings -@USArmy recovered $2B in unliquidated funds -@DeptVetAffairs saved $92M+ in funds -World Food Programme saved $30M in delivery costs -Jacobs Connect cut power usage by 30% -Panasonic decreased waste by 12% ESI Group sped up ERP harmonization by 70% -Panasonic Energy cut the 3-6 month learning curve down to just a few weeks for veteran technicians -PG&E reduced transformer ignitions by 65% -Eaton boosted productivity by 25%
$PLTR In case you forgot, here's a reminder of what Palantir is capable of -Heineken: "What took us three years before, the team built in just three months" -Citi Wealth: “This process would take 9 days. Now it takes seconds.”Citi has achieved a 90% decrease in time per case and an 80% cut down on handoffs, all while retaining the quality of their work. -General Mills: We’re saving on average about $40,000 a day, which is about $14M ANNUALLY– and it’s really only deployed to part of our network." -Fannie Mae: "It was a mortgage case fraud case... There's a lot of paper--reams of paper. It took our really talented investigators 60 days to detect fraud into these files. It took your technology 10 seconds, like holy cow." -Morson Group: 53% faster in finding x3 candidates. 1hr 8min average per consultant. 129% increase in placements made -Applied Materials: 24-month projects to 6 weeks. "We have big consulting companies coming in. We can do this in 24 months, it's going to be millions of dollars. With Palantir, we solved this in 6 weeks on the pilot just by connecting to those Legacy systems." -Walgreens increased the operational efficiency by 30% -Nebraska Medicine increased patient discharge speed by 2000% paired with a 95% discharge prediction accuracy -AIG reduced a four-week underwriting time to less than one day. -TeleTracking reduced 24-hour manual healthcare process to seconds -Bolt reduced checkout cancellations to 50% -U.S. Department of State can reduce the time it takes to clear candidates to the Foreign Service from 60 days down to 12 -HyperScienceAI and ManifestCyber reduced the FedRamp costs by 10x and its audit time by 94% -Walgreens increased its operational efficiency by 30% BP reduced costs per barrel by 60% Tampa -Hospital improved its nurse staffing ratio attainment by 30% Cleveland Clinic reduced its bed capacity calculation time by 75%, 38 Minute decrease in ER wait time and 40% Reduction in unused orthopaedic OR time -Paraxel reduced the Clinical Submission Readiness Time by 50% Morson group reduced x3 candidate search time by 53% -Airbus accelerated A350 production by 33% -Tyson Foods achieved $200 million in cost savings -@USArmy recovered $2B in unliquidated funds -@DeptVetAffairs saved $92M+ in funds -World Food Programme saved $30M in delivery costs -Jacobs Connect cut power usage by 30% -Panasonic decreased waste by 12% ESI Group sped up ERP harmonization by 70% -Panasonic Energy cut the 3-6 month learning curve down to just a few weeks for veteran technicians -PG&E reduced transformer ignitions by 65% -Eaton boosted productivity by 25%
Reminder: -Heineken: "What took us three years before, the team built in just three months" -Citi Wealth: “This process would take 9 days. Now it takes seconds.”Citi has achieved a 90% decrease in time per case and an 80% cut down on handoffs, all while retaining the quality of their work. -General Mills: We’re saving on average about $40,000 a day, which is about $14M ANNUALLY– and it’s really only deployed to part of our network." -Fannie Mae: "It was a mortgage case fraud case... There's a lot of paper--reams of paper. It took our really talented investigators 60 days to detect fraud into these files. It took your technology 10 seconds, like holy cow." -Morson Group: 53% faster in finding x3 candidates. 1hr 8min average per consultant. 129% increase in placements made -Applied Materials: 24-month projects to 6 weeks. "We have big consulting companies coming in. We can do this in 24 months, it's going to be millions of dollars. With Palantir, we solved this in 6 weeks on the pilot just by connecting to those Legacy systems." -Walgreens increased the operational efficiency by 30% -Nebraska Medicine increased patient discharge speed by 2000% paired with a 95% discharge prediction accuracy -AIG reduced a four-week underwriting time to less than one day. -TeleTracking reduced 24-hour manual healthcare process to seconds -Bolt reduced checkout cancellations to 50% -U.S. Department of State can reduce the time it takes to clear candidates to the Foreign Service from 60 days down to 12 -HyperScienceAI and ManifestCyber reduced the FedRamp costs by 10x and its audit time by 94% -Walgreens increased its operational efficiency by 30% BP reduced costs per barrel by 60% Tampa -Hospital improved its nurse staffing ratio attainment by 30% Cleveland Clinic reduced its bed capacity calculation time by 75%, 38 Minute decrease in ER wait time and 40% Reduction in unused orthopaedic OR time -Paraxel reduced the Clinical Submission Readiness Time by 50% Morson group reduced x3 candidate search time by 53% -Airbus accelerated A350 production by 33% -Tyson Foods achieved $200 million in cost savings -@USArmy recovered $2B in unliquidated funds -@DeptVetAffairs saved $92M+ in funds -World Food Programme saved $30M in delivery costs -Jacobs Connect cut power usage by 30% -Panasonic decreased waste by 12% ESI Group sped up ERP harmonization by 70% -Panasonic Energy cut the 3-6 month learning curve down to just a few weeks for veteran technicians -PG&E reduced transformer ignitions by 65% -Eaton boosted productivity by 25%
Reminder: -Heineken: "What took us three years before, the team built in just three months" -Citi Wealth: “This process would take 9 days. Now it takes seconds.”Citi has achieved a 90% decrease in time per case and an 80% cut down on handoffs, all while retaining the quality of their work. -General Mills: We’re saving on average about $40,000 a day, which is about $14M ANNUALLY– and it’s really only deployed to part of our network." -Fannie Mae: "It was a mortgage case fraud case... There's a lot of paper--reams of paper. It took our really talented investigators 60 days to detect fraud into these files. It took your technology 10 seconds, like holy cow." -Morson Group: 53% faster in finding x3 candidates. 1hr 8min average per consultant. 129% increase in placements made -Applied Materials: 24-month projects to 6 weeks. "We have big consulting companies coming in. We can do this in 24 months, it's going to be millions of dollars. With Palantir, we solved this in 6 weeks on the pilot just by connecting to those Legacy systems." -Walgreens increased the operational efficiency by 30% -Nebraska Medicine increased patient discharge speed by 2000% paired with a 95% discharge prediction accuracy -AIG reduced a four-week underwriting time to less than one day. -TeleTracking reduced 24-hour manual healthcare process to seconds -Bolt reduced checkout cancellations to 50% -U.S. Department of State can reduce the time it takes to clear candidates to the Foreign Service from 60 days down to 12 -HyperScienceAI and ManifestCyber reduced the FedRamp costs by 10x and its audit time by 94% -Walgreens increased its operational efficiency by 30% BP reduced costs per barrel by 60% Tampa -Hospital improved its nurse staffing ratio attainment by 30% Cleveland Clinic reduced its bed capacity calculation time by 75%, 38 Minute decrease in ER wait time and 40% Reduction in unused orthopaedic OR time -Paraxel reduced the Clinical Submission Readiness Time by 50% Morson group reduced x3 candidate search time by 53% -Airbus accelerated A350 production by 33% -Tyson Foods achieved $200 million in cost savings -@USArmy recovered $2B in unliquidated funds -@DeptVetAffairs saved $92M+ in funds -World Food Programme saved $30M in delivery costs -Jacobs Connect cut power usage by 30% -Panasonic decreased waste by 12% ESI Group sped up ERP harmonization by 70% -Panasonic Energy cut the 3-6 month learning curve down to just a few weeks for veteran technicians -PG&E reduced transformer ignitions by 65% -Eaton boosted productivity by 25%
I know it's not on here but I think I'm going to get some ESI (Element Solutions, Inc.) calls. Currently at $18.87. A shit ton of open interest on calls, much more than the "handful" of OI on puts, which are all the strike price down. It's been around $27 the past year, but it never recovered from the late march-early april market drop. This might be a good time to see a recovery for it, and at a premium of $0.70 for $20 and $0.30 for $22.5, both expiring May 16th, it seems like a good opportunity?
Anyone who bought puts yesterday when the market ESI was the lowest it’s been in history deserves to lose money
Sold the house 60 days ago, went cash hang on every account, rebalanced 401ks to be bond heavy, just turned on my employers ESI policy to buy on the way down every quarter, and I’m going to do what I couldn’t do back in 08 which is put a fuck ton into the market nearish the bottom and just let it do its thing. Probably going into stagflation so I’m thinking of pivoting and going heavy on international, I’m chatting with gpt about Japan’s lost decade and what stock plays their best traders did. Sounds like currency arbitrage was the play, not sure that’s an option here yet.
Did they succeed? “It was found that the chemical stability at neutral pH required for a drug candidate was not sufficient… This was partly related to deamidation and isomerization at asparagine residues but also the disulfide bridge.” The new analogs had the same problems as cagrilintide at pH 7, but also suffered from instability of the disulfide bridge. The disulfide bridge is critical for the biological functionality of amylin and also protects it from aggregation. This was likely an issue for cagrilintide as well, though it wasn’t reported—the researchers in that report said that instability of cagrilintide “included” deamidation, implying there were other kinds of degradation. “Degradation of the asparagine residues and general stability were significantly improved at pH 4.” Just like cagrilintide, these new amylin analogs were found to only be stable at a pH of 4. “Initially, it seemed likely that a neutral formulation was possible… However, as development of a neutral formulation not only caused deamidation but also involved disulfide bridge instability, it was decided to revert to using an acidic formulation.” Again like cagrilintide, and then NN1558, the researchers finally gave up on making this new amylin analog stable at a neutral pH. Now, onto the interesting insights they hadn’t shared in their cagrilintide report. Within the context of discussing the potential of amylin to form fibrils, here’s what they said: “The amino acid sequence of human amylin enables a process of misfolding whereby monomeric amylin initially forms soluble beta-sheet-rich oligomers that may be cytotoxic.” For the first time, Novo researchers are discussing not only fibrils, but also oligomers. To understand oligomers, imagine you have a box of LEGO bricks. Each individual brick is a **monomer** (mono meaning "one"). Now, if you connect a few of these bricks together, you create a small chain called an **oligomer** (oligo meaning "a few"). When two bricks connect, that's called a **dimer**, and three is a **trimer**. These oligomers, or short chains of amylin, then form bonds with each other in a side-by-side arrangement, forming sheet-like structures called beta sheets. They note here that oligomers “may be cytotoxic,” meaning toxic to cells. The research on amylin oligomers is actually much more conclusive than “maybe:” oligomers disrupt cell membranes, induce stress in the endoplasmic reticulum, cause mitochondrial dysfunction, increase oxidative stress, trigger inflammation, and damage DNA.[5] “Over time, these oligomers may mature further into elongated structures with a high content of beta-sheet strands and finally generate insoluble protein aggregates that are [visible under a microscope] as amyloid fibrils in islets.” Eventually, all those oligomers form fibrils in islets, which are small clusters of insulin-producing cells within the pancreas. “Some of these toxic oligomeric species are associated with beta-cell death and the progression of type 2 diabetes (16−18)” Here, they cite research showing that not fibrils, but toxic oligomers are what cause the death of the insulin-producing beta cells in the pancreas. This is from the first study cited: “The mature amyloid fibril is presumed to be relatively inert and to have no significant cell toxicity. Rather, smaller oligomeric intermediates formed during fibrillogenesis are thought to be cytotoxic.” That study goes on to point out that initially it was believed that fibrils are the cause of disease, but “subsequent reports have underlined that it is small, oligomeric [amylin] aggregates and not fibrils that constitute the toxic species.” “The stability properties of the individual amylin analogs were assessed with respect to their propensity toward amyloid fibril formation. The relative amount of covalent dimers and polymers (HMWP) present prior to fibril formation testing was [also] measured.” A dimer is two peptide molecules stuck together. The researchers are calling dimers “HMWP” (High Molecular Weight Products) along with longer oligomers that they’re calling polymers. After an amylin or cagrilintide molecule has been degraded and destabilized by a higher pH than 4.0, it then begins to stick to other amylin/cagrilintide molecules. This is the first step in becoming an oligomer, and as the Novo researchers have already established, oligomers are toxic to cells (leading to beta-cell death and progression of Type 2 diabetes). They used Thioflavin T (ThT) to test for fibrils, but we’re not really interested in fibrils since they’re nowhere near as harmful as oligomers. So here’s how they measured the amount of dimers: “Assessment of High Molecular Weight Product Content by Size-Exclusion Chromatography” Novo Nordisk uses Size Exclusion Chromatography (SEC) because it's the gold standard for assessing the presence of dimers and other oligomers. This is also the view of the US Pharmacopeia, which sets standards federal standards for drug products, as well as the FDA’s Senior Pharmaceutical Quality Assessor.[8] Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) may be considered the gold standard for separating and purifying peptide molecules, but this is not universally true. For example, ion exchange chromatography (IEX) is superior to HPLC for charged peptides.[9] For quantifying aggregates such as dimers and trimers, Size Exclusion Chromatography is considered the gold standard.[10][11] The reason the FDA and USP don’t advise RP-HPLC is because it’s not sensitive enough to detect dimers. If you analyze cagrilintide that has begun to aggregate using RP-HPLC, the dimers will elute about the same time, meaning they will still show up as monomers (single molecules). So the test results will still show high purity since the dimers are undetectable with this method. The pramlintide degradation study also supports this notion, as it employed a form of analysais even more sensitive than SEC to detect dimers called Electrospray ionization–ion mobility spectrometry–mass spectrometry (ESI-IMS-MS). The pramlintide study uses multiple tests to confirm the presence of oligomers because SEC has limitations.[12] Even deamidation, which is the form of degradation that cagrilintide goes through above pH 4 that leads to aggregation into dimers, cannot be adequately be detected with RP-HPLC.[13] The Bottom Line In Novo Nordisk’s own words, Cagrilintide ***absolutely** **must*** be formulated at a pH of 4.0. Much higher, and the peptides rapidly begin to degrade, leading to aggregation and the development of highly toxic oligomers. It is these oligomers themselves that are the most toxic species and not fibrils themselves. To test for the development of oligomers, Size Exclusion Chromatography (SEC) is the gold standard (at the bare minimum—there are also platinum and diamond standards). Anyone who tries to tell you that cagrilintide is safe (doesn't degrade) at a pH above 4.0 based on a test with anything less than SEC (including the RP-HPLC test from PTDS) is either ignorant or they have ulterior motives. They are asserting that they know better than Novo Nordisk themselves, as well as the US Pharmacopeia and the FDA. Extraordinary claims require extraordinary evidence—so what extraordinary evidence do they offer? Citations [1] https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00565 [2] https://www.jbc.org/article/S0021-9258(20)88558-5/fulltext [3] https://onlinelibrary.wiley.com/doi/10.1002/oby.23329 [4] https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00022 [5] https://pubmed.ncbi.nlm.nih.gov/33544470/ [6] https://pmc.ncbi.nlm.nih.gov/articles/PMC7288967/ [7] https://pmc.ncbi.nlm.nih.gov/articles/PMC4350773/ [8] https://www.usp.org/sites/default/f...riences-and-Expectations_Katharine-Duncan.pdf [9] https://www.mdpi.com/2297-8739/11/8/233 [10] https://www.waters.com/waters/library.htm?locale=en_US&lid=135068236 [11] https://pubmed.ncbi.nlm.nih.gov/28578190/ [12] https://pubmed.ncbi.nlm.nih.gov/27665170/ [13] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612368/
Shittastic job [https://www.google.com/search?num=10&sca\_esv=474c61ed372cb30b&q=3890+ibm&udm=2&fbs=AEQNm0Aa4sjWe7Rqy32pFwRj0UkWd8nbOJfsBGGB5IQQO6L3JyJJclJuzBPl12qJyPx7ESI1lx4tk7FSHYMadvuwITh8UlhAwiuNUzEITw-KIB2MS\_XCyXsB0gG3KZN-eNkhm-vyssH6Hm3\_b65nEAmIkcHCxDwIE-nJHV9JoDo20jUATojW\_l7q6FhtV8-Mw7XYZ1V3JF-kXbUEekoRWYQExio6bweDlw&sa=X&ved=2ahUKEwiPofqs3K-KAxWx78kDHY-NLEoQtKgLegQIGxAB&biw=1205&bih=563&dpr=1.59](https://www.google.com/search?num=10&sca_esv=474c61ed372cb30b&q=3890+ibm&udm=2&fbs=AEQNm0Aa4sjWe7Rqy32pFwRj0UkWd8nbOJfsBGGB5IQQO6L3JyJJclJuzBPl12qJyPx7ESI1lx4tk7FSHYMadvuwITh8UlhAwiuNUzEITw-KIB2MS_XCyXsB0gG3KZN-eNkhm-vyssH6Hm3_b65nEAmIkcHCxDwIE-nJHV9JoDo20jUATojW_l7q6FhtV8-Mw7XYZ1V3JF-kXbUEekoRWYQExio6bweDlw&sa=X&ved=2ahUKEwiPofqs3K-KAxWx78kDHY-NLEoQtKgLegQIGxAB&biw=1205&bih=563&dpr=1.59)
Or ESI express scripts. They are a PBM. every time a drug goes generic, the stock takes a nice jump
ESI earnings and only 100 shares moved?
Element solutions $ESI chip manufacturing and liquid cooling should begin to see real benefits -BUY
ESI - BUY WEAKNESS Stock will skyrocket on an dovish comments. Company will be a major player in the chip manufacturing/ electrification transformations globally
ESI 📈📈📈 element solution strong buy / calls
$ESI - Buy on weakness. Top smid-cap semi / chip play for 2024/2025
$ESI Element solutions BEST pick for 2H2024 Good entry point. Top pick idea
$ESI element solutions - BUY THE PULLBACK
Element Solutions $ESI price target raised to $33 at UBS. Company raised FY guidance . Buy - good entry
$ESI 📈 Element solutions should benefit from the ongoing chip / AI transformation. Mgmt raised FY guidance
$ESI Element Solutions (ESI) Ups Guidance, Sees Record EBITDA in FY24 The electronics business remains strong, with profitability improving - BUY 🚀
ESI. Element Solutions Inc Increases Second Quarter and Full Year Guidance📈🚀
You looked at ENTG, KGC, ESI, JMPLY or UMICY?
lol "human freedom" nothing says human freedom like opposing abortion rights, not understanding climate change and believing its a hoax and whatever this shit is: Milei promotes the far-right [Cultural Marxism conspiracy theory](https://en.wikipedia.org/wiki/Cultural_Marxism_conspiracy_theory). He uses *Cultural Marxism* as a label to accuse left-wing politics and progressives of enforcing [political correctness](https://en.wikipedia.org/wiki/Political_correctness).[\[153\]](https://en.wikipedia.org/wiki/Javier_Milei#cite_note-Fahsbender_2022-155) This includes usage of *Cultural Marxism* in reference to an alleged [gender ideology](https://en.wikipedia.org/wiki/Gender_ideology),[\[153\]](https://en.wikipedia.org/wiki/Javier_Milei#cite_note-Fahsbender_2022-155) [feminism](https://en.wikipedia.org/wiki/Feminism),[\[154\]](https://en.wikipedia.org/wiki/Javier_Milei#cite_note-GZERO_Media_2023-156) [LGBTQ movements](https://en.wikipedia.org/wiki/LGBTQ_movements),[\[130\]](https://en.wikipedia.org/wiki/Javier_Milei#cite_note-Crisp_2023-132) [minority rights](https://en.wikipedia.org/wiki/Minority_rights),[\[154\]](https://en.wikipedia.org/wiki/Javier_Milei#cite_note-GZERO_Media_2023-156) and public education and [comprehensive sex education](https://en.wikipedia.org/wiki/Comprehensive_sex_education) (ESI) in schools,[\[155\]](https://en.wikipedia.org/wiki/Javier_Milei#cite_note-Perfil_2022-157) which he has linked to brainwashing;[\[156\]](https://en.wikipedia.org/wiki/Javier_Milei#cite_note-Merco_Press_2022-158) he said that students are "hostages of a system of state indoctrination".[\[91\]](https://en.wikipedia.org/wiki/Javier_Milei#cite_note-Go%C3%B1i_2023-93) He intends to eliminate the law that makes ESI in schools mandatory,[\[199\]](https://en.wikipedia.org/wiki/Javier_Milei#cite_note-201) saying it is naive to think it would not be used for what he sees as indoctrination,[\[155\]](https://en.wikipedia.org/wiki/Javier_Milei#cite_note-Perfil_2022-157) and he wants to implement an [education voucher](https://en.wikipedia.org/wiki/Education_voucher) system to decentralize education by "giving the budget to parents".[\[9\]](https://en.wikipedia.org/wiki/Javier_Milei#cite_note-Chequeado_2023-9) Additionally, Milei linked *Cultural Marxism* to the [Ministry of Women, Genders, and Diversity](https://en.wikipedia.org/wiki/Ministry_of_Women,_Genders_and_Diversity_(Argentina)),[\[156\]](https://en.wikipedia.org/wiki/Javier_Milei#cite_note-Merco_Press_2022-158) and expressed his intent to abolish that ministry if he is elected president
ESI cause it’s manipulated and up and down like a fucking yo-yo
UNH, CRK, and ESI run the whole fucking show. they are untouchable
This guy is bullish because he thinks the FED will pivot and print more money: https://youtu.be/gvbP59F5ESI Gross as fuck.
The EU has some of the best data you can get, look for the ESI European sentiment index. It covers all cou tries in EU and EZ and has leading data for manufacturing, services, construction, retail and consumer confidence. Its a beast.
Nope, get into some Canadian ones like Ensign... ticker ESI trades on the Toronto Stock Exchange.
$AEMD $1.11?! at 52WKLOW BADLY oversold.. Average analysts price target is 600% higher from here at $6.50+! LOADING. Huge bounce coming. TINY FLOAT💸📈🛒 H.C. Wainwright Keeps a Buy Rating on Aethlon Medical (AEMD) Apr 20, 2022, 05:45 PM H.C. Wainwright analyst reiterated a Buy rating on Aethlon Medical ( – ) today and set a price target of $9.00. The company’s shares closed last Wednesday at $1.23, close to its 52-week low of $1.12. According to , Bernardino is a 5-star analyst with an average return of 24.9% and a 34.1% success rate. Bernardino covers the Healthcare sector, focusing on stocks such as Aridis Pharmaceuticals, Eledon Pharmaceuticals, and Citius Pharmaceuticals. Currently, the analyst consensus on Aethlon Medical is a Moderate Buy with an average price target of $6.50. Aethlon Medical’s market cap is currently $19.88M and has a P/E ratio of -2.00. TipRanks has tracked 36,000 company insiders and found that a few of them are better than others when it comes to timing their transactions. See which are most likely to make moves following their insider activities. Aethlon Medical, Inc. is a therapeutic technology company, which focuses on addressing global health and biodefense needs. It develops Aethlon Hemopurifier, a medical device that targets the elimination of circulating viruses and tumor-secreted exosomes that promote cancer progression. The firm operates through two segments: Aethlon and ESI. The Aethlon segment involves in therapeutic business activities. The ESI segment consists of diagnostic business activities. The company was founded by James A. Joyce in May 1998 and is headquartered in San Diego, CA.
A wind energy company was sentenced to probation and ordered to pay more than $8 million in fines and restitution after at least 150 eagles were killed over the past decade at its wind farms in eight states, federal prosecutors said Wednesday. NextEra Energy subsidiary ESI Energy pleaded guilty to three counts of violating the Migratory Bird Treaty Act during a Tuesday court appearance in Cheyenne, Wyoming. It was charged in the deaths of eagles at three of its wind farms in Wyoming and New Mexico. [https://www.npr.org/2022/04/06/1091250692/esi-energy-bald-eagles](https://www.npr.org/2022/04/06/1091250692/esi-energy-bald-eagles) ​ Lmao! seriously?
ESI, Ensign Drilling. A canadian driller with a sizeable US fleet. Decent balance sheet. Has moved quite a bit the last month but still has room to run if you think permian drilling is about to ramp up.
Im watching the fundamentals of the oil market. As long as demand remains strong and supply remains tight, i will be sticking around. That said i am watching the share prices of energy stocks and will be taking a decent amount off the table when shares are at historic highs. Right now im buying the drillers. HP, ESI, PDS, RIG these high prices will be calling every available drilling rig into service.
>\*Element Solutions Inc Issues Statement Regarding Cyber Security Incident $ESI ^\*Walter ^Bloomberg ^[@DeItaone](http://twitter.com/DeItaone) ^at ^2022-01-05 ^08:32:22 ^EST-0500
Why would ESI % of Free Float go down when exchange reported SI is going up?
PHX and ESI. I think ESI Is the one with more cash flow per quarter than total market cap. Except the price has gone up quite a bit so that may not be accurate any more. What ever it is it's a lot.
Investments for this Monday: $APPL $TSLA $PYPL $ESI $LEN what do you think? ​ Today I will start by investing on those stocks. I explain my idea on this video: https://youtu.be/kHZFcxp02zY but would like to get your feedbacks. What I want is to improve the way I invest and analyze the market. To force me to be more consistent on analyzing the market I decided to create a Youtube channel to record my ideas and plan a bit better the way how I invest. Feel free to give me your feedback.
They’re in a market dominated by monopoly powers: ESI, Caremark, and Prime. Paying cash for generics is great but they’ll find it hard to incorporate high margin drugs where pharmacies make the most money. Volume is there though. If Amazons PillPack reaches the buying power discounts that GoodRx has they’ll have stiff competition there. I personally stay far away from retail pharmacy.
ESI on tsx seems like a good play!
Heard you all like AMD, NVDA, ON, ESI, TSM, QCOM, AMAT, INTC chips. Any new flavours come up recently or do we gotta stick with the brand name chips?
Choose for me: YOLO POSH, SKLZ, CRSR, FEYE, ESI, CPNG
Fair enough, if you replace Express Scripts with Cigna via ESI the statement is still true though. ESI didn’t lose market dominance because they were acquired.
Check out ESI. 4/16 $20C premiums are still pretty cheap.
Try ESI.TO name of the company is Ensign Energy Services Inc. Please do your research before investing :)
ESI.TSE not showing anything..
Would like to draw you're attention to a stock ESI.TSE. strong company with good balance sheet. Has good asset strength. With oil prices climbing and rigs put back in operation, tremendous potential and results are just around the corner. Was darling of the markets and paid 30+% dividend
I posted my approach above. Good luck. The classic formula is ESI. Earn. Save. Invest. Great luck to you!
$ESI is a nice mid cap company that produces chemical solutions needed for the production of semiconductors wouldn’t be bad place to buy here