Reddit Posts
Vertex Pharma (VRTX)-the next Blockbuster for 2024
Ok, the loss of TTWO was expected, but why CRSP. I slept in and it's all gone.
CRSP FDA Approval Deadline Dec 8.
SPECIAL DATES IN MEDICAL HISTORY **NEXT MONTH**= FDA DECISIONS= Dec 8th 2023 FOR $CRSP & Dec 20th 2023 FOR $BLUE-Aprvd in UK Last Week.
CRSP Stock Surges after winning the first ever gene editing approval
CRSP 10k YOLO "First-Ever Gene-Editing Drug"
$CRSP play - possible first ever FDA Approval of Gene Editing treatment - Dec 8th PDUFA
beat Cathie Wood at her own agme (kinda) crispr time is ripe folks
beat Cathie Wood at her own agme (kinda) crispr time is ripe folks
beat Cathie Wood at her own agme (kinda) crispr time is ripe folks
VERVE therepeutics potential for the next boom boom?
CRSPR, Intellia, Beam, Pacific Biosciences, Illumnia, Editas, Invitae... Will any of these companies be huge in the future?
CRSP gets FDA panel support for sickle cell treatment.
What top 3 Bags are holding right now? And how much do you hate yourself?
Where can you find summaries of the historical fundamentals for an index?
Tale of the epic comeback…. Started with oil, ended with oil….
Moved from trading to investing. Question about losing positions.
Start Investing in ETFs: Growth ETF and Total World ETF
$CRSP CRISPR Therapeutics pending EMA and FDA Aprovel
~$18k gains, holding for a few months since the low. ignore the -100% its an error, hopefully ; )
Could Fidelity be hiding the fees of its zero ER funds?
5 Top-Ranked Small-Cap ETFs to Buy for the January Effect
5 Top-Ranked Small-Cap ETFs to Buy for the January Effect
MULN, NIO Stock Speculations. TSLA Stock Blitzed. BIIB CRSP & VRTX Stock...
$CRSP More or less 15% short that is a lot
Diversified Portfolio with Individual US stocks - 2023
What are your thoughts on ARKG ETF now as a long-term play?
$CRSP formed a cup and handle! It’s taking off 🚀. Let’s go BULLS!!! ☕️ 🐂
The biotech rocket getting ready for launch - $CRSP Crispr Therapeutics DD
What are YOUR long term holds? And is a large percentage of it tech- why or why not?
CRISPR DD that's not only lazy, but also manages to stack a few levels of uncertainly, meaning only a fool would give this any credence...
Only 4% of US stocks from 1926-2016 outperformed one-month T-Bills!!!
My portfolio is trash. Should I sell all of it?
Big Pharma destroying small cap Biotech SGMO
Where’s the volume for gene editing stocks (CRSP, EDIT, NTLA, BEAM, etc.)?
Am I crazy for buying the following stocks at the prices listed here?
Research: The History and Evolution of SPACs, The Causes of the SPAC Boom, Why Companies SPAC, and Who Invests in SPACs
Opportunities in Options Around Earnings This Week
Opportunities in Options Around Earnings This Week
Opportunities in Options Around Earnings This Week
My bearish vertical put spread expired in-the-money. I think I lost the total value of the spread
DD on DTIL (gene editing company) I am hoping people can critique
Your next hard-on? What’s your next intrinsically undervalued target for DD then buy/option?
All this talk about $CSCR and no discussion about $CRSP
Romancing the Wood - a TA/DD of your favorite, can't possibly fail, Cathie Wood investments! (TSLA, CRSP, PLTR, WKHS, TDOC, ROKU, SQ, JD, BABA & HOOD)
My main positions are getting too expensive to dollar cost average
Actionable Trading MRNA SRPT CRSP GSK PFE MODERNA HITS $100 Billion GENE RNA MED
$NTLA and $REGN announce that they have successfully corrected a hereditary disease with an infusion of CRISPR
$NTLA and $REGN announce that they have successfully corrected a hereditary disease with an infusion of CRISPR
NTLA, CRSP, EDIT, BEAM, VERV, ARKG likely to fly on Monday
NTLA, BEAM, CRSP, VERV, EDIT, and ARKG likely to fly on Monday
Mentions
CRSP with the vertical line pre market
Looking like tomorrow gunna be another CRSP autumn day
Bought CRSP and now it’s dipping
Why are we bullish CRSP?
Already printing calls on CRSP 16 Jan 75$ and 80$ strike. And NTLA 16 Jan 25$ and 22.5$ 🚀
CRSP $75 strike Im gonna lose it all
Donnie announces his intent [to direct the federal government] to buy $CRSP to facilitate his ambition to beat Xi and Puti Tang to immortality.
someone posted about $CRSP yesterday and i got 1k of calls. now im sittin on 2k of calls. oh fuhhh.
CRSP looking good amirite?
take me to the promised land CRSP
Yup tide is rising on gene editing. CRSP, BEAM, VRTX for the win
If you want to get into gene editing, then CRSP is the wrong way. It's old tech. No one does ex-vivo therapy since it's very expensive, far too invasive and not some thing you can mass produce to make profitable. $2M-$3M per patient, what insurance company is going to pay that. Requires flushing out all your bone marrow to work, far to invasive. Even CRSP knows this since they are now pivoting towards in-vivo which is non-invasive, can be mass produced, and can therefore can be commercialized. All CRSP wanted to do was get first to market but they are now so far behind with in-vivo. It's the reason why VERV got bought out and NTLA is pumping.
Isn’t CRSP a huge piece of shit
Peter Lynch’s ten-bagger strategy comes to mind. If you put $100 and it grows 10x now you have $1k. If you can flip that to another ten-bagger now you are at $10k. Try to find 10 ten-baggers. Something like CRSP which has a lot of potential not based on any fundamentals or technicals and more the technology platform itself. You are essentially buying the dream-backed by Nobel-Prize winning science and validated by FDA approval.
WSB doesnt let me post original posts. I wanted to post about NTLA at 9$ in May. CRSP is a great company, however NTLA is where the explosive growth is, in early 2026 it will be $40 solid. Insiders buying, positive trial news
mRNA and siRNA technology are different. One produces proteins, the other silences production of proteins. But to both of your points - it's about sentiment. The QURE news will likely pump both MRNA and CRSP because of industry progress and sentiment. That's why CRSP and MRNA hit 200 and 350 respectively in 2021 - sentiment positions: long CRSP since Feb
If you like CRSP, take a look at VRTX as well. Recently pummeled but they take 60% of the profit from CRSP's Casgevy treatment which has just started rolling out.
I like my options CRSP and worthless LFG
You can argue they're both forms of gene therapy... however, Injecting an RNA via viral vector is MRNAs technology. Its exactly how the COVID shot worked. Actually cutting DNA and splicing the gene itself is Very different with much worse risks that have occurred which is why CRSP and EDIT got knocked for years after killing people. You may be right that CRSP will go up, and i also do believe in their potential, but your DD about QURE is irrelevant and actually applies to MRNA QURE was a huge deal, I'm actually ecstatic. QURE worked by injection of RNA via viral vector. For that reason, MRNA is what was validated by QURE, NOT CRSP. - science degree in some bullshit nobody cares about
Cathie wood [Cathie’s new holdings](https://cathiesark.com/arkk-holdings-of-CRSP)
CRSP has very little to do with QURE. QUREs technology it's RNA... you should buy MRNA, not CRSP
#TLDR --- Ticker: CRSP Direction: Up Prognosis: Buy JAN '26 $80 Calls Catalyst: Massive 30% short interest, significant insider buys for the first time in years, and positive regulatory tailwinds for the gene therapy sector.
Bruh forget the rest of this boomer bingo card, $CRSP is the real lottery ticket. We’re literally talking about editing human cheat codes at the DNA level while the rest of your portfolio is out here trying to sell socks on the internet. Yeah it’s volatile, yeah it bleeds faster than my brokerage account after FOMC minutes, but if they nail even one therapy it’s tendies for life. This is either “retire in Bali” or “working night shift at Wendy’s” money, and I’m here for it. Diamond hand the science, paper hand the rest. 🚀🧬
Cathie wood been selling the shit out of ROKU and TEM and buying the shit out of CRSP and BLSH. But CRSP I’m pretty sure she’s bag holding so she just buys every dip to eventually break even
$CRSP looking good and ready to pump!
$CRSP looking good and ready to pump!
$CRSP looking good and ready to pump!
CRSP is probably my riskiest one. I do like the space of gene editing but many others like BEAM and NTLA also doing well. They have good cash reserves and good progress. But 2 major factors for me… 1. While treating sickle cell is great, not much scale. But their phase 1 CTX310 is looking promising and focuses on cardiovascular health which is huge. I believe gene therapy is at infancy still and promising. 2. Recently a board director just bought a massive $50M mid-July. Some secondary factors… they have good cash runway, great brand recognition and this admin may be more favorable to medical trials and innovation. Could also be an acquisition target if trials progress. I don’t expect much day-to-day but don’t want to miss trial progress news or even acquisition.
Wheel is great. Why $CRSP?
Have no idea what qualifications HOOD used for summit. Not sure if it is balance or activity. I have a personal style if trading that works for me. Usually about 3-6 months. This past year, it was NVDA, then PLTR, then HOOD. Hard to summarize it all but basically when bullish, I look for best of the best. Then I set some milestones for exits. My next milestone for HOOD exit is 9/19 (maybe a few days after). I also shift my strategy based on risk. 1 wheel (low) 2. Leaps (mid) 3 shorter term ITM options (high). I am transitioning from 2 & 3 to low risk wheel. I will likely just hold CRSP, HOOD, ASTS, TSM and maybe RDDT (nervous about recent runup). Maybe even look into something like GDX as a hedge. I really like the income generation of wheeling sticks with some bit of volatility like above.
RKLB, SNAP, CRSP, and UPS about to go wild today for all the bears
Stocks: I would sell UNH and CRSP. The rest are excellent. Be ready to buy more of them on dips. ETFs: You have too many. Focus on QQQ and VOO. Fine to add JEPQ and JEPI if you want monthly income from covered call ETFs. Crypto: This will be the most volatile portion of your portfolio. I agree not to contribute more. Let it ride and trim a little on price surges. You are in great shape.
DYOR - don't just take a random person on the internet's advice. I haven't been buying as much in 2025 as I consider myself to be well positioned from purchases the last few years. But in 2025 I have averaged up on AMD, bought heavily into CRSP and adjecent companies, and as mentioned above, have been buying datacenter plays, such as CRWV, NBIS and IREN. I also bought the dip on TradeDesk. You can also see my history that I am looking for industries that won't experience a 75-90% drop in a bear market. For that reason, I stay away from space stocks, quantum computing stocks and SMR stocks. I will be interested in them when the next big crash comes along, for whomever is still around at that point.
Hi all! Here’s my current portfolio with percent allocations: • NVDA: 20.6% • TSM: 9.7% • PLTR: 9.6% • AAPL: 8.9% • QQQ: 7.4% • VTI: 7.1% • MSFT: 6.9% • GOOGL: 6.8% • NUKZ: 5.9% • META: 5.7% • SOFI: 3.0% • TAN: 1.8% • BND: 1.8% • AMD: 1.4% • SCHD: 1.3% • AMZN: 1.0% • DRIV: 1.0% • JEPI: 0.9% • O: 0.2% • QTUM, ESPO, SPMO, UNH, CRSP: <1% each Notes: • I know this portfolio is very tech-heavy. • I contribute monthly to each position for dollar cost averaging, except for NVDA. I’ve paused monthly NVDA contributions to help balance its weight versus other holdings. • I don’t have as much time to monitor the market actively as I used to. • Should I consider consolidating or simplifying my portfolio for easier management? • I’m open to suggestions on better balance, or ideas for adding/removing stocks and ETFs. Thanks for your input!
Bingo. And tbf, most of history is a few winners. Old comment of mine: Turns out stock-picking is very hard and cap-weighted works for a reason. Few winners hard carry everyone. >“The results also help to explain why active strategies, which tend to be poorly diversified, most often underperform,” says Bessembinder, who found that the largest returns come from very few stocks overall — **just 86 stocks have accounted for $16 trillion in wealth creation, half of the stock market total, over the past 90 years.** https://wpcarey.asu.edu/department-finance/faculty-research/do-stocks-outperform-treasury-bills Competition, new disruptive threats means companies go bust and lose often: >I calculate that the approximately 25,300 companies that issued stocks appearing in the CRSP common stock database since 1926 are collectively responsible for lifetime shareholder wealth creation of nearly $35 trillion, measured as of December 2016. However, just five firms (Exxon Mobile, Apple, Microsoft, General Electric, and International Business Machines) account for 10% of the total wealth creation. The 90 top-performing companies, **slightly more than one-third of 1% of the companies that have listed common stock, collectively account for over half of the wealth creation.** The 1,092 top- performing companies, slightly more than 4% of the total, account for all of the net wealth creation. That is, the remaining 96% of companies whose common stock has appeared in the CRSP data collectively generate lifetime dollar gains that matched gains on one-month Treasury bills. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2900447
Haven’t seen CRSP named in a while
Just go with (VT) or (VTI + VXUS) or (VTI + SPDW). These are all ETFs. —>VT = total world stock market. Tracks the “FTSE Global All Cap Index.” Invests in (emerging markets + developed markets). Invests in (small cap companies + mid cap companies + large cap companies). VT, or the index that it tracks — will automatically account for GLOBAL GEOPOLITICAL POLITICS. Aka: If the US were to “significantly lose its economic status,” (FTSE Global All Cap Index), VT will automatically, and overtim, (have a higher allocation to INTERNATIONAL COMPANIES) and (lower allocation to US COMPANIES). ->current allocation: (65% US equities + 35% international equities). ->US loses economic status allocation: (55% US equities + 45% international equities). ->You see the (re-balancing part)? This happens overtime, and automatically. No need to worry about (a single country experiencing hyperinflation/black swan event/etc). —>VTI = total US stock market. Tracks the “CRSP US Total Market Index.” Invests in 100% (US equities) or (US companies). Invests in (small cap companies + mid cap companies + large cap companies). VOO would just track only (large cap US companies). —>VXUS = total international stock market. Does not include US companies. (emerging markets + developed markets). —>SPDW = total international stock market. Does not include US companies. Only (developed markets). ->In my opinion, I would just go with (VT). Simple, and diversified. You do not have to worry so much about certain hypothetical scenarios. Rare events, but you never know what is going to happen in the future
CRSP, game changing healthcare technology to potentially cure genetic diseases
Most people don’t have patience for 5 years, but if you do: CRSP
Agree on CRSP. Great potential and they’re having exciting trial results. I would love to hear your take on LUMN. I almost bought it earlier this month but didn’t. They’re up 18% since then and now I’m kicking myself.
Should I yolo my 90 year old mothers savings into $CRSP $BEAM and $NTLA ?
Sorry that and CRSP. Lmao. Your post history is crazy bro
Good lord bought some CRSP calls just for it to drop 5% in the last 10 fuckin minutes
Man that pos stock I sold as soon as I broke even, fkn CRSP randomly dumps 5-10 percent in a day
oh look more $CRSP insider buying
As I mentioned in another comment, the benchmark uses the MSCI indices for each country, gross return (i.e. inclusive of dividends), denominated in USD. Specifically, it uses the investable market index (IMI), which also includes smaller companies. There isn't an ETF product directly linked to the MSCI USA IMI index, but this is basically completely correlated with the CRSP US Total Stock Market index, to which VTI is benchmarked. They basically [move together](https://i.imgur.com/JCuCF1c.png). There also aren't ideal country-specific ETF products to track the IMI. For instance, the [MSCI China IMI index](https://www.msci.com/indexes/index/664216) has 784 holdings, but Blackrock's MCHI tracks MSCI China, not the IMI, and only has 550 holdings. It also has an expense ratio of 0.59%, and similary across the board for all the country-specific ETFs. You do get a better comparison if you go with broad international ETFs, instead of country specific ones: - Blackrock's IDEV tracks the MSCI World ex USA IMI index for 0.04% (developed ex-US). - Blackrock's IEMG tracks the MSCI Emerging Markets IMI index for 0.07%. As you can see, there is some slight tracking error between the ETFs and the indices they track, but it has actually favored the ETFs so far this year (i.e. better for investors).
I expect RSP to underperform SPY but it'll still be green. Just not as good as the monster money printers. And tbf, most of history is a few winners. Old comment of mine: Turns out stock-picking is not so easy that anybody can do it and most stocks are crap. >“The results also help to explain why active strategies, which tend to be poorly diversified, most often underperform,” says Bessembinder, who found that the largest returns come from very few stocks overall — **just 86 stocks have accounted for $16 trillion in wealth creation, half of the stock market total, over the past 90 years.** https://wpcarey.asu.edu/department-finance/faculty-research/do-stocks-outperform-treasury-bills Competition, new disruptive threats means companies go bust and lose often: >I calculate that the approximately 25,300 companies that issued stocks appearing in the CRSP common stock database since 1926 are collectively responsible for lifetime shareholder wealth creation of nearly $35 trillion, measured as of December 2016. However, just five firms (Exxon Mobile, Apple, Microsoft, General Electric, and International Business Machines) account for 10% of the total wealth creation. The 90 top-performing companies, **slightly more than one-third of 1% of the companies that have listed common stock, collectively account for over half of the wealth creation.** The 1,092 top- performing companies, slightly more than 4% of the total, account for all of the net wealth creation. That is, the remaining 96% of companies whose common stock has appeared in the CRSP data collectively generate lifetime dollar gains that matched gains on one-month Treasury bills. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2900447
Revenge investing is a good way to lose more money. Not saying it's a bad idea to invest in stocks, but you'd be starting investments in SHOP, PLTR after huge earnings gaps, NVDA after it has doubled in 3 months with no pause, and CRSP which is probably just as risky as the biotech that destroyed your account. You lost thousands by not having a plan. So have one before you just randomly throw $200/week at stocks.
Turns out stock-picking is not so easy that any retard can do it and most stocks are shit. >“The results also help to explain why active strategies, which tend to be poorly diversified, most often underperform,” says Bessembinder, who found that the largest returns come from very few stocks overall — **just 86 stocks have accounted for $16 trillion in wealth creation, half of the stock market total, over the past 90 years.** https://wpcarey.asu.edu/department-finance/faculty-research/do-stocks-outperform-treasury-bills Competition, new disruptive threats means companies go bust and lose often. And that's great for society. >I calculate that the approximately 25,300 companies that issued stocks appearing in the CRSP common stock database since 1926 are collectively responsible for lifetime shareholder wealth creation of nearly $35 trillion, measured as of December 2016. However, just five firms (Exxon Mobile, Apple, Microsoft, General Electric, and International Business Machines) account for 10% of the total wealth creation. The 90 top-performing companies, **slightly more than one-third of 1% of the companies that have listed common stock, collectively account for over half of the wealth creation.** The 1,092 top- performing companies, slightly more than 4% of the total, account for all of the net wealth creation. That is, the remaining 96% of companies whose common stock has appeared in the CRSP data collectively generate lifetime dollar gains that matched gains on one-month Treasury bills. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2900447
CRSP crash is a leading indicator, risk off is beginning
for real though why did that director drop $50M on CRSP
Look for calls on CRSP and AEVA instead.
Selling my OCT expiry CRSP puts somewhere between \~$51.50 and \~$47.
CRSP fuckin me today with a surprise earnings release. There goes my port ☹️
Since fucking when was CRSP reporting today??
It's another r/collapse for retards like you. Go back in your hole. >Equal weight has been getting crushed and some people trade things other than SPY sir. It’s like 3 companies holding this together There's a reason why SPX is not equal weighted? Lmao. You act like this isn't 100% normal. Turns out stock-picking is not so easy that any retard can do it and most stocks are shit. >“The results also help to explain why active strategies, which tend to be poorly diversified, most often underperform,” says Bessembinder, who found that the largest returns come from very few stocks overall — **just 86 stocks have accounted for $16 trillion in wealth creation, half of the stock market total, over the past 90 years.** https://wpcarey.asu.edu/department-finance/faculty-research/do-stocks-outperform-treasury-bills Competition, new disruptive threats means companies go bust and lose often. And that's great for society. >I calculate that the approximately 25,300 companies that issued stocks appearing in the CRSP common stock database since 1926 are collectively responsible for lifetime shareholder wealth creation of nearly $35 trillion, measured as of December 2016. However, just five firms (Exxon Mobile, Apple, Microsoft, General Electric, and International Business Machines) account for 10% of the total wealth creation. The 90 top-performing companies, **slightly more than one-third of 1% of the companies that have listed common stock, collectively account for over half of the wealth creation.** The 1,092 top- performing companies, slightly more than 4% of the total, account for all of the net wealth creation. That is, the remaining 96% of companies whose common stock has appeared in the CRSP data collectively generate lifetime dollar gains that matched gains on one-month Treasury bills. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2900447
CRSP - Casgevy sales updates at 4:30 via VRTX
CRSP is gapping up right now Large volume orders after crossing $59 Think this could run back to $70+ this week
CRSP running on the daily into expected earnings/updates…
$CRSP could fly tonight with $VRTX providing CASGEVY results
You almost always miss the boat following the herd. For those of us married to the game we are dialed in to as much pertinent information as possible. If I don’t know the answer, I know someone that does know. If you miss it there is someone else to dance with. The answer to your question is yes there are more like Nvidia. You probably won’t see them on Reddit though. One of the beginning stages of investing is what should I buy? Eventually as you become more nuanced you find plenty of stocks you can buy. The question ceases to exist. Then it becomes about the money to be able to invest in those ideas. Some stocks I think have big potential for growth in that space. RXRX-CRSP-ARM are a couple in my AI portfolio. The strategy has no trailing stops and we are buying on the dips until 2030. CRSP is one of the rare situations where fundamentals aren’t a major consideration. We are investing in the potential of the technology. I still think this has the potential to be a ten-bagger and possibly mint some millionaires.
Yup. Just added ITM leaps for CRSP, HOOD, ASTS, TOS. We’ll see how the next 6-12 months shapes up.
Get ready for CRSP to skyrocket this morning 🎉
Are you buying any dips today? We could go down more but who knows? Picking up some CRSP ahead of next week earnings
Why are CRISPR stocks ($BEAM, $CRSP, $NTLA) so heavily shorted?
Aug22 CRSP call. Just closing my eyes and pointing
CRSP calls An insider literally bought $50 million worth of stock two weeks ago Earnings early next week, including VRTX update on Casgevy sales Generous dip yesterday was due to NVO and UNH dragging down the whole sector
So I’ve used ChatGPT in a loosely similar manner, and the complexity of the prompt (plus deep level follow on conversation) is what really helps drill down to what you’re looking for. Based on a lengthy discussion about thesis, aggressiveness, convictions, etc, I asked it to recommend 10 stocks to round out exposure in key areas, and it recommended BLK, COIN, VRTX, REGN, NTLA, CRSP, SNOW, PDYN, SMR, and ARKW ETF. I made purchases of three of these and I’m up ~40% since.
Went balls deep in CRSP calls for next week’s earnings
still thinking about the CRSP insider who bought $51M worth of shares lol
I like CRSP calls here
Cathie Woods offloads CRSP... now it will rise lol
I’m in $IBB and $CRSP
Internationally based stocks. Im in on CRSP, N u holdings, and Rolls Royce. Trying to hedge against US BS lol.
CRSP $50mil insider purchase, readouts coming, ER in 2 weeks
Long: RKLB NVDA TSLA CRSP Mid: Saving for above. Short: Think about saving for above.
CRSP $50mil insider purchase, readouts coming, ER in 2 weeks
That’s a great point RE: non-dilutive capital raise. I didn’t know they were exploring that. CRSP did the same thing- they gave Vertex 10% more of the casgevy profit share for $1B in cash
CRSP is definitely better positioned regarding cash. Though last earning call Intellia’s CFO was pretty confident about capital position and pointed out that in 2-3 year timeframe also collaboration or some royalty arrangement could be subsitute/addition to the capital raise. Either way, I am quite confident on the future of both companies.
Director of CRSP just dropped $50mil which has a $5B market cap. One of the largest insider purchases of any company. That’s twice the money for a company 2% the size of UNH. And CRSP is curing disease. UNH is denying disease. Fuck UNH.
CRSP is a pretty easy swing trade, likes to pop up and down a lot, but rarely keeps dumping
Looking like CRSP and the whole gene-editing space could be the next big thing.
I am holding it for the long term, although given the recent massive insider buy from SR One, the short term seems very enticing too. Wait out biotech until phase 3 success or approval and there will be no upside. By the time phase 3 starts, they are usually sufficiently de-risked. Phase 2 is where the most gains are usually made. As for semaglutide beating it to market and eating its lunch in CVD: No study has shown semaglutide reduces CVD risk in non-diabetics or people with normal BMI (not obese). And based on how it works, it wouldn’t reduce CVD risk in those populations anywhere near mainstay treatments. It would be complimentary to a subset of the patient population at best. The reason why it reduces CVD risk in diabetics and obese individuals is mainly because it treats diabetes and obesity, meaning diabetes and obesity themselves are risk factors for CVD. The genes CRSP’s CVD pipeline targets are among the most genetically validated targets in CVD. Lp(a) is high in 20% of the population, and is worse than LDL-C and there is not treatment for it on the market. Its gene is known, and it has been almost eliminated in studies and CRSP’s own trial. Same with ANGPTL3 for LDL and TG and AGT for hypertension. These are all proven endpoints for clinical trials in CVD. Noncompliance is a huge issues in medicine in general, especially CVD patient population. Semaglutide and the like are extremely overblown by the media and celebrity doctors. They’re not a magical drug. They’re just more obese people than lay people realized. What is CRSP is targeting is proven. The effect they will have on the risk of CVD is proven. That’s why they are validates clinical endpoints. Proven, in biology, means a lot. Not many others can claim that. Why? Because these genes are known based on loss of function mutations in humans to have these effects. So, in a sense, the clinical trial has already been done. What’s actually being tested is the toxicity and gene delivery modality. And the initial toxicity data that just came out looks great. And the gene editing platform, using crispr instead of prime editing or newer modalities like its competitors is a better strategy because it has a much longer track record, we know more about it, and the off target effects based on studies is so minimal that even if you used other modalities it wouldn’t make a difference and would come with much more significant trade offs.
They have active trials, an approved therapy, and IMO best gene therapy platform. I have a medical background so I have some knowledge in this space. If there in vivo pipeline works, there will be a CURE for hypertension and high cholesterol. Basically eliminating all CVD risk. Noncompliance for CVD is very high. This is one and done. Also those a million other biotechs are usually 1 or 2 trials away from insolvency. CRSP has probably the best balance sheet of any.
Dude I was waiting for CRSP to cure COVID. They're doing a lot of cool shit I'm too dumb to understand right now, call me back when they have something marketable, until then there's a million other biopharmas to gamble on with active trials
CRSP is going to pop off when it can cure herpes
JIM CRAMER just said CRSP “CAN TRIPLE FROM HERE OR STAY FLAT. GREAT SPECULATIVE STOCK”. With all the momentum behind it recently, take that as you will.