Reddit Posts
CRSP is heading to $25 before it goes up to $97 (in 4 years)
Trump just signed an EO to fast-track psychedelics. ATAI ($1.4B) and GHRS ($1.04B) are Phase 3-ready with FDA Breakthrough designations.
Any tax implications/forced sale if/when a massive company gets absorbed into VT/VTI?
$PACB: A beaten down genomics stock with disruptive technology, increasing revenues, and very interesting partnerships (DD from someone who works with their tech regularly)
Why don't more people talk about and invest in indexes built by academics and economists with decades of data behind them ?
Total market ETFs are about to become exit liquidity for mega upcoming IPOs like spaceX and openAI
Building 2 portfolios : 3-stock long-term bag + 3-stock moonshot bag
Building 2 portfolios : 3-stock long-term bag + 3-stock moonshot bag
Building 2 portfolios : 3-stock long-term bag + 3-stock moonshot bag
PayPal ($PYPL) - Agentic AI and insane option flow
CRISPR ($CRSP) - Sector Tailwinds, Insider Buys & Massive SI
Why are CRISPR stocks ($BEAM, $CRSP, $NTLA) so heavily shorted?
CRSP is set up for a gamma-fueled squeeze, 30% float, 9.4 days to cover, 1.76 billion total shorts, 10% APR, underwater for 5 weeks, total pain over 250 million
CRISPR Therapeutics (CRSP) Short Sqz Loading...
The Portfolio I’d Build If I Worked at Berkshire Today
Ignore our little dog friend on here... I see some reoccuring things on here, KULR, MRIN, BYND, OGEN, CRSP. This list is fucking loaded. Squeezefinder Watchlist. Bonus AI watchlist. 1July2025
CRSP seriously undervalued, see below
Gene-Editing Stocks Gain on LLY-VERV Deal Announcement
Crispr seriously undervalued with new Verve comp
I want yo rebalance my portfolio based on new market trends - DATA/PRIVACY-SENSITIVE TECH, RENEWABLE ENERGY + BIOTECH - advice?
Anyone else making sense of the market movement?
$CRSP – The Next Short Squeeze? Analysis of an Overlooked Opportunity
$CRSP Timing is everything. With the technology brining back Dire wolves and treating rare diseases and cancer and diabetes and $2B in cash
$CRSP Timing is everything. With the technology brining back Dire wolves and treating rare diseases and cancer and diabetes and $2B in cash
Market Performance by U.S. Government - 100 Years of Data with Post-Liberation Day Update
Vertex Pharma (VRTX)-the next Blockbuster for 2024
Ok, the loss of TTWO was expected, but why CRSP. I slept in and it's all gone.
CRSP FDA Approval Deadline Dec 8.
SPECIAL DATES IN MEDICAL HISTORY **NEXT MONTH**= FDA DECISIONS= Dec 8th 2023 FOR $CRSP & Dec 20th 2023 FOR $BLUE-Aprvd in UK Last Week.
CRSP Stock Surges after winning the first ever gene editing approval
CRSP 10k YOLO "First-Ever Gene-Editing Drug"
$CRSP play - possible first ever FDA Approval of Gene Editing treatment - Dec 8th PDUFA
beat Cathie Wood at her own agme (kinda) crispr time is ripe folks
beat Cathie Wood at her own agme (kinda) crispr time is ripe folks
beat Cathie Wood at her own agme (kinda) crispr time is ripe folks
VERVE therepeutics potential for the next boom boom?
CRSPR, Intellia, Beam, Pacific Biosciences, Illumnia, Editas, Invitae... Will any of these companies be huge in the future?
CRSP gets FDA panel support for sickle cell treatment.
What top 3 Bags are holding right now? And how much do you hate yourself?
Where can you find summaries of the historical fundamentals for an index?
Tale of the epic comeback…. Started with oil, ended with oil….
Moved from trading to investing. Question about losing positions.
Start Investing in ETFs: Growth ETF and Total World ETF
$CRSP CRISPR Therapeutics pending EMA and FDA Aprovel
~$18k gains, holding for a few months since the low. ignore the -100% its an error, hopefully ; )
Could Fidelity be hiding the fees of its zero ER funds?
5 Top-Ranked Small-Cap ETFs to Buy for the January Effect
5 Top-Ranked Small-Cap ETFs to Buy for the January Effect
MULN, NIO Stock Speculations. TSLA Stock Blitzed. BIIB CRSP & VRTX Stock...
$CRSP More or less 15% short that is a lot
Diversified Portfolio with Individual US stocks - 2023
What are your thoughts on ARKG ETF now as a long-term play?
$CRSP formed a cup and handle! It’s taking off 🚀. Let’s go BULLS!!! ☕️ 🐂
The biotech rocket getting ready for launch - $CRSP Crispr Therapeutics DD
What are YOUR long term holds? And is a large percentage of it tech- why or why not?
Mentions
Yep, NASDAQ is not the only one affected - CRSP (tracked by VTI and many other Vanguard funds) changed their rules earlier this year: https://www.crsp.org/crsp-market-indexes-changes-to-float-shares-investability-screen/
You need to look in the fund's prospectus, and see what benchmark index methodology they're using. Again using VTI as a convenient example just because I was digging through it recently (for this same reason), this is what their documents say: "The Fund’s Target Index, the CRSP US Total Market Index, **is a float-adjusted market cap weighted index**."
Depends on your retirement fund no? If you are only using funds that track NASDAQ then yes. But I would assume that the majority of people have something more diversified like VTI which tracks the "CRSP US Total Market Index"
Oh hey you're right, it's Market Cap Free Float for [CRSP](https://www.crsp.org/indexes/crsp-us-total-market-index/)
Yes, CRSP only waits 5 days on IPOs lmao https://www.crsp.org/wp-content/uploads/guides/CRSP_Market_Indexes_Methodology_Guide.pdf
I just sold some and some NVDA, MRVL. Bought 1000 shares of NTLA @ 13.53. I don't always follow Cathie Wood, but I believe she's on to something with Intellia Therapeutics. They use CRSPR technology. I recently bought CRSP 500 shares @ 55.08, of which Wood has been buying that as well. She also recently unloaded some of her AMD position.
That may be more so because they're not mirroring the CRSP in the same way those other funds are. A lower dividend % isn't necessarily a bad thing if it still captures the broad basket that is US markets and lowers taxable events.
We have data for the US stock market of varying quality since 1881 for the S&P from Shiller or 1926 for the Total US stock market from Fama French, although much of this data is retroactive, as the S&P 500 didn't exist until 1957 and the CRSP didn't exist until 1960. Nonetheless, we do know that over the 100 years covered by the Fama-French data set, the geometric average return of S&P 500 is 10.41% and the total US stock market is 10.36%. However, the median returns are 15.14% and 15.73%, respectively, since the negative years are much more punishing to cumulative returns than the positive years are helpful, so we've simply been fortunate to avoid a string of negative years. To the extent that we've entered a new regime, this occurred after we broke off the Bretton-Woods gold standard in 1971 ([before](https://testfol.io/?s=5Kvg09yX3Tq) vs. [after](https://testfol.io/?s=eV9adm9pPf6)). Nominal stock returns have been higher, but so have inflation and risk-free treasury returns: |Nominal CAGR (Median)|Before 1971|After 1971| |:-|:-|:-| |S&P 500|\+9.47% (+12.17%)|\+11.18% (+16.27%)| |Total US Stock Market|\+9.34% (+13.77%)|\+11.17% (+16.72%)| |Inflation|\+1.87% (+1.69%)|\+3.90% (+3.02%)| |Risk-Free Rate|\+1.99% (+1.44%)|\+4.99% (+5.12%)| tl;dr the median return is always higher than the CAGR and the nominal returns have been much higher after we left the gold standard.
VTI follows a CRSP Total (US) Market index. SpaceX would be included at their free-float market cap when added to the index. That “free float” market cap excludes shares held by company executives (Elon Musk, primarily) and large institutional investors (Google, Fidelity). It looks like they will have a $75 Billion offered publicly at the beginning, and assuming the valuation does not change between IPO and index inclusion, would make up \~0.11% of the \~$75 Trillion total free-float market cap of the index. If SpaceX’s valuation were to increase, or if there were additional publicly traded shares (from smaller employee holdings, or institutional investors selling shares prior to index inclusion) that would increase the percentage inclusion in the index.
Well damn, I owned CRSP at around $15, sold somewhere in the mid 30's. I guess should have held longer. I personally feel CRSP is a better company overall than SpaceX - there's a reason they have multiple nobel prizes for their tech. The big issue is they've always had trouble translating their technology into a scalable product that generates revenue, letalone profit.
if CRSP stock was a person I would murder them. What a shit stock
CRSP has always been all about being the total market index, not really the prime issue. S&P, have they even decided yet?
CRSP is pulling a "hold my beer" and fast tracking in 5 days, which means VTI will be impacted.
> or that Space X is audited every year NASDAQ is fast tracking SpaceX so there will only be 15 days for price discovery. CRSP is making it happen in 5 days. S&P will also be fast tracking and removing pesky requirements such as "demonstrate profitability". Simultaneously, SpaceX is also pushing for allowing insiders to cash out on the first day of the IPO and removing all shareholder powers: https://arstechnica.com/space/2026/04/spacex-finally-files-for-ipo-targets-1-75-trillion-valuation/ > SpaceX was toying with the idea of allowing some existing shareholders to sell down their stakes in the company on its first day of trading, according to people close to the deal. > This would do away with guidelines that typically prevent insiders cashing out of their positions for 180 days after a company’s market debut. https://www.reuters.com/sustainability/boards-policy-regulation/spacex-ipo-gives-musk-sweeping-power-curbs-shareholder-rights-2026-05-06/ > Excerpts of SpaceX's IPO registration statement reviewed by Reuters show the company is combining supervoting shares, mandatory arbitration, stricter rules on shareholder proposals and Texas corporate law to give Musk and other insiders broad control. At the same time, it sharply limits investors' ability to challenge management, sue in court and force votes on governance issues. > And the only person who can fire Musk is Musk, who will retain majority control through supervoting shares. > “It closes the voting door, the courthouse door and the proposal door simultaneously. It’s unprecedented in terms of creating a total lack of accountability,” said Bruce Herbert, CEO of Seattle-based sustainability-focused wealth management firm Newground Social Investment, which challenged Musk at his electric-vehicle company, Tesla (TSLA.O), opens new tab, with a shareholder proposal that won 49% of the vote in November.
10 to 20bps. 50-60bps tops in the near term. SpaceX is looking to raise 75B on a 1.75T valuation, that's only 4.3% float. 75 billion divided by the 65 trillion in the US Total Stock Market index's cap, you're at like 0.11% CRSP would add after 5 trading days per their rules. Final exposure % can vary based on the market weighting and free float - but if you play around with the numbers even assuming things like doubling in value, later secondary offerings increasing float - it doesn't really get that high
Following the NASDAQ's lead. CRSP is also joining in with fast tracking, which means the VTI fund will be impacted.
> Probably because Tesla didn't need to beg the S&P committee to bend the rules for them. Actually it started with NASDAQ. Once NASDAQ bent over, S&P and CRSP are following suit.
> What's even the point of owning this dogshit if you as an owner have no rights? That's the neat part, any index fund investors will be forced into it. Multiple indexes will be fast tracking SpaceX or considering it: https://finance.yahoo.com/markets/stocks/articles/elon-musks-spacex-could-fast-180121306.html > The rule changes include letting IPOs enter the index six months after their debut on an eligible index instead of a 12-month period, according to current rules. > The index also proposed eliminating a minimum Investable Weight Factor (IWF) of 0.10 for megacap companies. The IWF is a methodology used to calculate the number of shares of a company available to trade on the market. > Notably, the proposed rule changes also eliminate profitability requirements for megacap companies. Current rules require a company to be profitable on a GAAP basis for 12 months to be considered for the index, but that rule could be eliminated. Vanguard's VOO has a market cap of over $900 billion, and it's not the only index fund that will be following the new rules. VTI's CRSP index is also implementing the fast track changes: https://www.crsp.org/wp-content/uploads/guides/CRSP_Market_Indexes_Methodology_Guide.pdf
Multiple indexes will be fast tracking SpaceX or considering it: https://finance.yahoo.com/markets/stocks/articles/elon-musks-spacex-could-fast-180121306.html > The rule changes include letting IPOs enter the index six months after their debut on an eligible index instead of a 12-month period, according to current rules. > The index also proposed eliminating a minimum Investable Weight Factor (IWF) of 0.10 for megacap companies. The IWF is a methodology used to calculate the number of shares of a company available to trade on the market. > Notably, the proposed rule changes also eliminate profitability requirements for megacap companies. Current rules require a company to be profitable on a GAAP basis for 12 months to be considered for the index, but that rule could be eliminated. Vanguard's VOO has a market cap of over $900 billion, and it's not the only index fund that will be following the new rules. VTI's CRSP index is also implementing the fast track changes: https://www.crsp.org/wp-content/uploads/guides/CRSP_Market_Indexes_Methodology_Guide.pdf
And VOO, VTI, the list goes on... VOO has a market capitalization of over $900 billion. VTI's CRSP index is also implementing the fast track changes: https://www.crsp.org/wp-content/uploads/guides/CRSP_Market_Indexes_Methodology_Guide.pdf I also took a look at the Thrift Savings Fund that is the 401k for federal employees and military personnel. They only get 5 fund choices through Blackrock; a S&P500 index, a small US cap index, an international index, and the last 2 are bonds or US Treasuries. There are the lifecycle funds, but they all use a blend of the 5 funds.
Per the index that VTI tracks: [Seasoning of New Securities: new securities are eligible for index inclusion if they fulfill at least one of the two following conditions: \[...\] The first day of regular way trading on a CRSP exchange of interest was at least 5 trading days before the ranking day and the company’s capitalization is greater than or equal to the lower breakpoint of the CRSP US Small Cap Index.](https://www.crsp.org/wp-content/uploads/guides/CRSP_Market_Indexes_Methodology_Guide.pdf)
gm CRSP and biotech calls
Gene editing, starting to show success and on the forefront of medicine curing diseases. With this logic should demand high valuations, with some established leaders like CRSP, and many others competing. Yet as a whole, the sector has failed to impress the markets and has had a steep sell off from COVID highs. With many bagholders like myself. So I think market/popular narrative towards a sector has a lot to do with these valuations currently and can turn bearish when focus shifts
Xfinlink.com is pretty good, their data is point in time accurate (their entity resolution is actually somewhat on par with CRSP) & though they dont have real time yet you can probably workaround by connecting to ur broker
CRSP (gene editing), but will realistically need 5 years to 10x. absolutely undervalued, platform technology with 7 therapies in the clinic. regulators in favor of the technology and are actively trying to reduce time/cost to approval. already one approved drug, $2.3 billion in cash (they have no problem getting $600 million senior convertible notes in this macroeconomy, at a conversion rate 50% higher than current price and an interest rate significantly lower than inflation). big money has loaded up. over 90% is institutional, and it’s more than 20% shorted (probably some naked shorting too).
NTLA will announce they have the HAE cure and the first in-vivo treatment which is actually commercially viable unlike the CRSP ex-vivo cure. If data is good, they will go from market cap of 1.6B back to 10B in the next year since the HAE market is substantial.
Anyone saw that CRSP NTLA shake out? What do you make of it
Damn why is CRSP dumping? Almost bought a bunch of it yesterday.
15 days after SpaceX IPO, it will be fast-tracked to NASDAQ. Other indexes such as S&P and Morningstar are following NASDAQ's lead: https://www.reuters.com/legal/government/morningstar-considers-revamping-index-construction-ahead-spacex-ipo-2026-04-20/ > Morningstar, eyeing not only the pending SpaceX launch but also other similarly mammoth deals from companies like Anthropic and OpenAI later this year, said it will introduce what it refers to as an alternative way to gauge liquidity of these "unicorns" immediately following their debuts. This would address what is known as the free float requirement, or the requirement that a new public company have a minimum number of shares publicly available for trading. > Morningstar said its CRSP Market Indexes will "undergo enhancements to introduce an alternative liquidity screen", making it possible to add SpaceX and other giant IPOs to these benchmarks more rapidly. The funds that use the CRSP indexes as a portfolio benchmark include Vanguard's $607 billion Total Stock Market ETF. I've been looking at alternative index funds that don't strictly follow NASDAQ, S&P500 and CRSP, but still compare their performance to the indexes, such as Dimensional and Avantis ETFs.
Got one more article, this one is where Morningstar is introducing an even faster track for SpaceX and later IPOs: https://www.reuters.com/legal/government/morningstar-considers-revamping-index-construction-ahead-spacex-ipo-2026-04-20/ > Morningstar, eyeing not only the pending SpaceX launch but also other similarly mammoth deals from companies like Anthropic and OpenAI later this year, said it will introduce what it refers to as an alternative way to gauge liquidity of these "unicorns" immediately following their debuts. This would address what is known as the free float requirement, or the requirement that a new public company have a minimum number of shares publicly available for trading. > Morningstar said its CRSP Market Indexes will "undergo enhancements to introduce an alternative liquidity screen", making it possible to add SpaceX and other giant IPOs to these benchmarks more rapidly. The funds that use the CRSP indexes as a portfolio benchmark include Vanguard's $607 billion Total Stock Market ETF.
I sold CRBU end of December for the tax offset. Feel dumb about the reason I bought it in the first place. Some rando on Reddit in a CRSP post mentioned CRBU and that was enough for me. No DD really, just some random guy on Reddit who sounded smart and thought it was a good buy. I've had a few of those.
Is CRSP ever gonna rocket up? Or is too much retail still in it?
Because they buy IPO’s very early compared to even spy. I’ve mostly been adding VT since last April and I’ll likely flip most of my Vti into Vt. We have at least a few months. We don’t want to own space x or open ai.. open ai is really a dumpster fire and that’s a huge reason Microsoft is under so much pressure. https://youtu.be/6a9L-3Hiobs Cheers! Why VTI usually gets IPOs earlier VTI tracks the CRSP US Total Market Index, which: Includes nearly the entire investable U.S. market Adds IPOs once they meet basic liquidity + float requirements Often brings them in at the next quarterly rebalance (sometimes sooner for big names) 👉 Result: IPOs can enter VTI within weeks to a couple months.
Doesn't VTI follow CRSP US Total Market Index? I thought they already fast track IPOs and add them within 5 days. I'm not sure what percent float they require.
CRSP rules are here: [https://www.crsp.org/wp-content/uploads/guides/CRSP\_Market\_Indexes\_Methodology\_Guide.pdf](https://www.crsp.org/wp-content/uploads/guides/CRSP_Market_Indexes_Methodology_Guide.pdf) Page 11 deals with new securities (aka IPOs). The default is to wait 20 days and 12.5% float. But there's a "fast-track" whereby it can be 5 days and 10% float. I can't find the rules which govern whether a new security gets fast-tracked.
Yes , this already happens with the CRSP US Total Market Index I believe
This isn't going to affect VTSAX , VTSAX does not follow the nasdaq 100 index, it follows the CRSP US Total Market Index. I really doubt the CRSP indexes will change their rules
Might become VTI or VT and chill - I know VTI uses CRSP not S&P or Nasdaq and VT uses FTSE Global All Cap Index. There's also VXUS if you want a dash of International exposure.
Vanguard follows S&P 500 Index & the CRSP index. I wonder if they would change their rules too.
My last search said they both were considering it as well. Vanguard's VTI follows CRSP and as of now they're not considering a rule change. They do have a fast-track rule but SpaceX doesn't meet it since they're only offering 5% float and CRSP requires at least 10%. Not sure what OpenAI and Anthropic are offering float wise.
😮 No idea. But that's 1 of only 2 health stocks I own in my Roth. (Other is CRSP) What am I missing?
>I appreciate the skepticism, but there’s a misunderstanding here about index mechanics. The misunderstanding is yours. >If Nasdaq creates a 'Fast Entry' express lane for a trillion-dollar IPO, it forces broad-market index providers (like CRSP and S&P) to accelerate their own inclusion dates to avoid 'tracking error.' That is simply false. CRSP and S&P are free to construct their indexes however they want. Tracking error is not applicable in this context. >While the prospectus mentions 80%, Vanguard and BlackRock managers are strictly measured by how perfectly they track the index. Right, and only the Nasdaq indexes would include the IPO. >All technical citations regarding SEC Release No. 34-104968 and Rule SR-NASDAQ-2026-004 have been manually verified for accuracy. What does "manually verified" mean? Your links to SEC Release No. 34-104968 and Rule SR-NASDAQ-2026-004 are **made the fuck up**. They have nothing to do with Nasdaq's intention to include companies in their index earlier after a large IPO. That proposal is about a continued listing requirement for small companies.
I appreciate the skepticism, but there’s a misunderstanding here about index mechanics. 1. Index Agnostic: Funds like VTI and VOO track the entire US market, including stocks listed on Nasdaq. If Nasdaq creates a 'Fast Entry' express lane for a trillion-dollar IPO, it forces broad-market index providers (like CRSP and S&P) to accelerate their own inclusion dates to avoid 'tracking error.' 2. Leeway vs. Math: While the prospectus mentions 80%, Vanguard and BlackRock managers are strictly measured by how perfectly they track the index. They can't just 'opt-out' of a $100B+ inclusion without their fund failing its primary mission. My concern isn't clickbait; it’s about forced volatility. When the 'Fast Entry' rule waives seasoning, it forces every broad-market index fund to buy during the Day 15 hype peak, rather than waiting for a stable price floor. The reason I’m posting this information is because several people across several forums are mentioning it. People are either in disbelief or feel there is nothing we can do. I asked Gemini if there was anything the average index fund investor could do and this information was presented. I appreciate collaboration with others who are more familiar with any or all of the legalities. --- Transparency Note: Research and drafting for this post were assisted by Gemini 3 Flash (March 2026 version). All technical citations regarding SEC Release No. 34-104968 and Rule SR-NASDAQ-2026-004 have been manually verified for accuracy. Final analysis and conclusions are the sole responsibility of the human author.
VTI tracks the CRSP index, which is a few thousand companies. I posted about it [here.](https://www.reddit.com/r/investing/comments/1ru1gw4/why_the_spacex_ipo_should_be_concerning_to/oailxls/) But yeah, based on that after about 20 days on Market it would be included in VTI.
Also CRSP isn't changing any rules, right? The float will be properly weighted?
I think it must just be the [CRSP US Total Market index.](https://www.crsp.org/wp-content/uploads/guides/CRSP_Market_Indexes_Methodology_Guide.pdf) > ADD THRESHOLDS > An uninvestable security that has subsequently passed all of the investability drop screens for four consecutive rankings (now considered for reinclusion) must also pass the more restrictive add thresholds before it can be readmitted (added back) to the CRSP Market Indexes. > • Market capitalization ≥ $15 million > • Float ≥ 12.5 percent > • Sparse trading score ≥ .001 > • Consecutive days of zero volume < 10 > • Not currently suspended
I honestly don't even care if this is a scam, whether you're a salesman or not i gotta admit you caught my stoned attention, i still understand nothing and won't get into the topic of graphene stocks as I'm poor as shit and my $27 in CRSP is down 13%. What I'm getting at is It was an entertaining read, thank you
Turns out Beam is down 63% over the last 5 years and CRSP is down 48%. Congrats, you both lose!
CRSP director did this in June last year (around $50m) and the share price went from around $40 to $80 in the space of a few months
This is the kind of post everyone should see before they get too confident about their stock picks. I've done similar lookbacks on my own "conviction" ideas from a few years ago and the hit rate is embarrassingly low. The thing that stands out to me is that the actual 10x winners (VRT, SMCI, NVDA) weren't the ones people were hyping. They were mostly boring infrastructure plays that got pulled into a megatrend nobody fully saw coming. Meanwhile the "obvious" picks like BYND and CRSP had great narratives but the fundamentals never backed up the valuation. I think the honest takeaway isn't just "nobody knows" but specifically that narrative-driven picks have a way worse hit rate than fundamentals-driven ones. The companies that actually 10x'd had real revenue growth and expanding margins, not just a compelling story. Curious what process people use to actually separate the signal from the noise when researching stocks, because everything feels like a great narrative when you're buying.
CRSP needs more love, they are actually doing great things. Bring back 2021 damn it.
Considered splitting my Amazon position and buying CRSP this morning before it took off lol
It's just ok. If president pu55y grabber didn't start a trade war it would have been a lot better. Obama had the 2nd best returns under any president. Biden didn't do too bad in 2024. [S&P 500 Performance by President](https://www.macrotrends.net/2482/sp500-performance-by-president) 2024 Returns - Dow Jones Industrial Average 12.88% - S&P 500 Index 25.02% - CRSP US Total Market Index 25.81%
>2025 Returns - Dow Jones Industrial Average, 14.9% - S&P 500 Index, 17.9% - CRSP US Total Market Index 17.10% That's some pretty serious winning. I'm buying the dip(s)
Considering the DOW is only about 30 stocks the S&P 500 or the CRSP US Total Market Index would better represent the entire US market better than the DOW. 2025 Returns - Dow Jones Industrial Average, 14.9% - S&P 500 Index, 17.9% - CRSP US Total Market Index 17.10% Also, saying the DOW hit 50,000 means nothing. If someone asked how well your car performs would tell them it has 50,000 miles on it?
Hey! Sorry I’m late to this thread, but I just wanted to add I have almost an identical portfolio to you : RKLB instead of ASTS, NBIS, CRSP, BULL instead of HOOD, and for nuclear energy part, was debating between TLN or VST instead of SMR. What are your thoughts on those 2 (TLN and VST)
"the FDA is shifting its default policy to require only **one** adequate and well-controlled clinical study for new drug approvals, dropping the long-standing two-study standard." Lowkey biotech might be the play here. has recovered some but still pretty damn cheap since agent orange took office. Lot of room to run up potentially I like IOVA and CRSP but XBI is the easy bet
One day CRSP will come through, hopefully AI can help accelerate their research. But I’m with you about Healthcare, such a boring slow growth sector. I’d probably do a 60%GEV/30%GE/10% GEHV split or something like that. Definitely grabbing GE before GEHC though!
Funny..I have a small chunk of CRSP too..down 20% from when I purchased a few months back..but agree that it has moonshot potential. Healthcare just feels like a crapshoot but GE seems to know how to execute and the name to back it up. I'll be continuing to watch it and probably jump in at some point when the time seems right. Its pretty reasonably priced.
I literally have no exposure to Healthcare besides CRSP… which is basically just a small moonshot position. Looking for one a little more established but also on the “growth” side. The GE’s kinda seem like a holy trinity
Yup, I've started going into gene therapy (e.g., CRSP, BEAM) and antibody/peptide design companies (e.g., ABSI, ABCL, GMAB) myself
I dislike target date funds. If you're okay with slightly more risk for more return on average, see if they have a low expense ratio S&P 500 or CRSP index. Honestly since you're holding until retirement the risk added is marginal.
Any news on buy out for CRSP?
Thank you, this CRSP index was exactly what I was imagining. Thanks for the lead.
Yes, but it seems odd that the "CRSP US Large Cap Growth Index" with more holdings would be more top heavy. That's what I'm really trying to understand.
They track different index’s why would they be the same? From the Vanguard website: “VUG seeks to track the performance of the CRSP US Large Cap Growth Index”. QQQM is the top 100 stocks in the NASDAQ.
Vanguard Institutional Total Stock Market Index is close enough to VOO that you shouldn't worry about the difference. It and VTI both "seek to track the performance of the CRSP US Total Market Index."
CRSP US Total Market Index uses free float market capitalization. If they IPO at $1T and only 5% of the shares are trading, they'd be weighed as is they were $50B companies.
CRSP US has a total market cap of $64 trillion, so $1T would be 1.5%, which is less than yesterday's max drawdown
First of all, they do not "have to buy on Day 1". It takes times for indexes to adjust. Moreover, indexes like S&P 500 have profitability requirements for any stocks they hold. They must be profitable in the previous quarter and profitable over the sum of the last 4 quarters. Because of this, they can't even enter the index for at least year after IPO. Even VTI's index CRSP US Total Market Index only reconstitutes quarterly, and has rules for who can be included. Beyond that, you could argue that it's all priced in anyways.
No dude.. CRSP US Total Market also have eligibility rules. Must trade for at least 4 trading days before they are eligible for "Fast-Track" inclusion. Also even if SpaceX IPOed at a massive $500 billion valuation, it would only represent about 1% of a total market fund like VTI. You’re right about being exit liquidity though. The VCs made their money and are selling it to the public and you missed the 100x growth in the private sector.
It doesn't mean the funds tracking the CRSP have to add it immediately, only at the next quarterly rebalance. Even if the IPO company times it perfectly to go public shortly before the rebalance, there will be at least some days the company will be public before being added to the total US market funds (probably enough to be dumped if the market decides it).
You're thinking of the S&P 500. Total Market funds (VTI) are different. VTI tracks the CRSP US Total Market Index. CRSP has a 'Fast Entry' rule specifically for massive IPOs. If a company is big enough to qualify for the Large Cap basket (which a $1T OpenAI obviously would), CRSP adds it to the index within 5 trading days
You're thinking of the S&P 500. Total Market funds (VTI) are different. VTI tracks the CRSP US Total Market Index. CRSP has a 'Fast Entry' rule specifically for massive IPOs. If a company is big enough to qualify for the Large Cap basket (which a $1T OpenAI obviously would), CRSP adds it to the index within 5 trading days
Here is how Cathie Woods largest holdings performed in January 2026 Tesla $TSLA -4.3%🔴 Crispr $CRSP -4.7%🔴 $ROKU -12.3%🔴 Tempus AI $TEM +1.3%🟢 Coinbase $COIN -13.9%🔴 Shopify $SHOP -18.5%🔴 $AMD +10.5%🟢 Robinhood $HOOD -12%🔴 $BEAM -0.3%🔴 Teradyne $TER +24.5%🟢
I like investing in biotech, have never invested in EDIT (or CRSP, NTLA are other ARKG-ish names that have often come up.) "biotech winter" There's a lot of things that have done well. XBI actually had a good year last year. " if literally anything goes right (data, partnership, asset sale, etc) the stock could reprice hard." True, but at $2, you have to take into account that a lot EDIT-specific has not gone right, it isn't just the sector. This isn't down 97% since late 2021 because of factors beyond the company.
5 years ago, Cathy Wood, right? CRSP has done nothing since her great promotion.
I got tired of researching and babysitting individual stocks. I’m entirely ETFs with the exception of AAPL shares I’ve owned for many years, and some shares of CRSP as a gamble.
Glad to hear it’s 1/3 of portfolio (unlike this subs tendency to “yolo” full accounts), but man idk about CRSP. Wishing the best for you though! Ps. I do not trust Cathie Wood and neither should anyone based on some hilariously uninformed statements she’s made in the past
the only hope for CRSP is to get acquired ive been bullish on the technology since it existed but look at their revenue and their market cap one single draw down on the market will bring this back to 30 im a buyer under 50 but not above
CRSP and NTLA are have the biggest potential in gene editing.
They definitely don’t “have all the patents.” The core CRISPR IP is owned by universities and licensed across the industry, including by CRSP. They do have strong patents around their specific therapies, but they still pay royalties like everyone else. They’re early on approvals v competition, but that doesn’t magically short-circuit reimbursement, manufacturing, or timelines to meaningful revenue.
I think CRSP has all the patents, they were the first ones, and I believe they are the first ones to provide approved therapies. The question is really, when will the market realise the impact and future value? Currently they believe in AI.
I'm a little heavy into CRSP as well but not ready to full port. Bio tech and bio engineering definitely has a future wave but not sure which company will be king.
My money is on CRSP. Current leader in gene editing with a long runway of cash burn. But I’ll admit right now im flipping it. I buy when it’s low, sell when it’s high. Long term I think it’s a winner, but whether itll hit big time in 2 years or 20 years i have no idea.
not a big investing guru😂 Plan stays the same... Consistant VWCE, ISOE and then handpicking some bonbons😅example: TEVA, SLB, CRSP, OKLO, TM and so on... (mostly smaller amounts just to have a position and see where things are going) +crypto +silver/gold
I found CRSP from a YouTube short about mapping genes. Had nothing to do with the stock.
CRSP Leading gene editing company.
What is up with CRSP today? Up almost 10%
I rarely hold a stock that long. Most people don’t hold a stock that long. We can’t prognosticate that far into the future. More importantly, what is your exit strategy? Without a strategy you are just a seal swimming amongst the sharks. Will you freak out if one stocks drops 50%? I already know the answer yet it begs the question. Are you doing any Fundamental Analysis? Technical Analysis? I don’t care for your picks, no disrespect. Your question is more complicated than you may think. I will play my part lest it be said I’m a curmudgeon. BRKB- buy the dips EQR- buy the dips CTRE COPY- buy the dips ABBV PSHZF CRSP- buy the dips until 2030 MKL This is what I have that I could reasonably conceive one may own ten years from now. I added CRSP for future potential rather than Fundamental or TA. Not my best work but what can you expect for free.