MD

iShitBloodandCumShit

Id be safer shotgunning a retro 4loko with a bottle of MD2020 screwed into it than getting off this toilet. Kids haven’t learned that “mom” is over stimulated. And I for certain don’t want to get in between that lmao.

CMTTrader

MD, outside DC. Last year, they popped off fireworks every day for a week AFTER July 4th too LMAO

hseeman_sf

There are are number of things you need to look at in 10K, not just in isolation but reading 2-3 years of 10Ks sequentially, very hard to do it without tools. That said, LLMs are great at precisely this kind of work. You could ask the LLM to do the following (this is not an exhaustive list by any means, add/delete as you see fit for your own process): * **Gross Margin Trajectory:** Extract 3-year gross margins; flag any compression relative to revenue growth. * **Operating Leverage:** Identify fixed vs. variable costs and evidence of declining customer acquisition costs. * **Capital Efficiency:** Calculate Return on Invested Capital (ROIC) and track CapEx as a percentage of revenue growth. * **Shareholder Dilution:** Calculate YoY share count growth and Stock-Based Compensation (SBC) as a percentage of operating cash flow. * **Customer Concentration:** Flag any single client accounting for >10% of total revenue. * **Accounting Red Flags:** Identify changes in revenue recognition (Notes 1/2) or shifts toward capitalizing rather than expensing development costs. * **Unique Vulnerabilities:** Extract non-boilerplate risks (e.g., single-supplier reliance, third-party platform dependency). * **Narrative Drift:** Compare the MD&A to the prior year and list any strategic initiatives that quietly disappeared.

adjust_your_set

Exactly. 10-k information is for institutional analysts and big investors so they can tweak the risks and assumptions in their earnings models. The average retail or individual investor isn’t going to gain much investing insight from those disclosures, or make investment decisions based on what is in the MD&A.

thanatos0320

Financials, MD&A, and that's it.. you could check out the notes if you wanted as well, but there is no need to read everything in the notes. There is also point in reading the risk every single time either.

konamul

To be honest you should use AI, especially considering institutional investors already do. It’s not like they have a junior analyst sitting reading a 100 pages nowadays. But because the context is so large AI can hallucinate. So they create a templatized report and use parsing algo data streams to ensure accuracy like [AlphaCreek](https://www.alphacreek.ai). The reason you need to specifically parse it is because if you only want to know about management sentiment, LLM should only pull the MD&A the rest would be bloat. If LLMs are not pulling the exact parsed area, it will just try to stitch something that “makes sense” throughout the 100 pages - where people are saying it hallucinates. It also saves significant token consumption as you can imagine it only reads the paragraph needed and not the entire document

steady_compounder

You do not need to read a 10-K like a novel. I would start with the business summary, MD&A, segment results, cash flow, and then only dive into the risk factors or footnotes when something looks off. The real goal is not to consume 100 pages, it is to find what changed, what management is emphasising, and what could break the thesis.

Heavy_Nothing_1158

Two things made 10-Ks less miserable for me: don’t read them front-to-back, and don’t start with Risk Factors (that section is basically corporate anxiety fan fiction). For Apple I’d usually do: 1. MD&A first: revenue by segment/geography, gross margin, buybacks, services growth. 2. Notes: debt, share count, R&D, legal/regulatory stuff. 3. Risk Factors only as a diff: what changed vs last year? Then keep a tiny checklist: “what would make me wrong?” If you can answer that after 30–45 minutes, you probably got more value than from three heroic Twitter threads and one espresso-fueled hallucination.

viserys8769

You’ve been opening it for 3 years and suddenly you feel it’s too long? Read the MD&A that should be enough.

ComprehensiveKiwi489

MU says it locked in 16 entities on multi-year escalating chip deals. Translation - The collapse of the US economy quickens, inflation goes higher faster, and shortages in supply chains will be unbearable. The MD/A of Hyperscalers will be atrocious since 5 are already holding $2 trillion in commitments. The same will be true for Anthropic, OpenAi, etc.

TH3PhilipJFry

Like doctors have been supplanted by web MD

forreelforrealmang

MD?

HairyBushies

Could be a doctor or someone that needs a lot of schooling. Essentially age 22/23 when graduating undergrad, a few years in medical school, and a few years of residency. Then in your first year as a fully licensed MD you’re earning a couple hundred grand whereas before they were earning nothing or just enough to live. Basically they just started working and saving whereas before it was all school, residency, etc. and basically living on loans or a small stipend with nothing left over to save. So, yes, the math absolutely could math… it’s just not something you’re familiar with so it seems strange.

Bright-Quiet-5622

Former Banker here covering the tech sector. Worked on Wall Street for big banks for 8 years. Quit right before making MD. Get an MBA and as soon as you start school, start networking right away especially with the 2nd year students who interned recently. To be honest I hated my time as a banker (not such a fun place for a woman who never did drugs and hated hanging out with the boys / boss) but it pulled me out of poverty and now I am retired (early 40s). I still use the knowledge and discipline for making a living (trading stocks)

x90x90smalldata

Low. Very low. Maybe 1% of Exeter, or similar, graduates become MDs. Prob 10x harder coming from public school. Now, thousands get the entry level job at a good investment house. Hundreds make VP. Dozens make MD. The mountain is steep and every level up is a hockey stick in comp. By the time you reach MD, the comp can be 10x what it was just a few rungs lower. Plenty of people spend there entire careers never making those heights and still earn an exceptional living.

SharpStrategist

Dad needs to be an MD

mtnrnnr802

There are people this stupid https://www.reddit.com/r/wallstreetbets/s/aPYy3MY8MD

JohnnySpot2000

Capital gains is not 35% in the USA, it’s either zero, 15%, or 20% taxes marginally. Maryland has a capital gains tax, but if it’s your primary home, you don’t pay any tax for the first $250,000 in gains if single (USA and MD).

Efficient-Fudge-3515

I’m an MD

Jkayakj

FYI psychiatrists are doctors/physicians and are MD/DOs...

SpeakerAltruistic123

I’m married to a MD who sees a huge need for improvement in the area of burn wound assessment

ItInProg

Initial jobless claims up to 225k vs. 215k est. & 212k prior; continuing claims at 1.777M vs. 1.780M est. & 1.785M prior … greatest increases in CA (+3.9k), TN (+1.7k), & MN (+1.7k); greatest decreases in TX (-2.2k), NJ (-1.2k), & MD (-0.8k)

Direct-Bar-7392

Extremely Unspecific for an MD

Direct-Bar-7392

Most MD's don't make 50k a month lmao

OrdinaryMix4013

Your package arrived late at our BALTIMORE, MD facility due to a delay in transit. We’re getting it back on track and have adjusted your delivery estimate. fuk u jeff bezos

OrdinaryMix4013

#jeff bezos my amazon package is supposed to be delivered in TX today, but it was just scanned in MD. wtf u slot mofo

ArtisticFrame5790

I was thinking the MD in his name was for Maryland but maybe it’s for medical doctor.

UnclePsilocybe

Their username had MD in it 

outoftownMD

MD.

callsonreddit

is it really that pricy? MD costs 250k

wsurrdit

Few things: 1. Capex is real money. Today’s spending, and related revenue for those hardware companies, is legit. Tomorrow, however, is never guaranteed. 2. The market is all about momentum. It started with point 1 but doesn’t need to stay grounded there. 3. I work in a related industry. If larger companies that have hundreds+ of engineers can have AI write mediocre code, the tokens they buy probably cost less than the salaries of their first-year engineers. In response to OP’s opening statement - the ripping is mostly 2, started with 1, but 3 has legs. Today feels inflated to me but it’s definitely not going anywhere and it will be showing up (or expected) in earnings of public company MD&A over 1k employees within next 12 months.

Tim_Apple_938

After researching all day it seems my main options are try to say the magic words to my doctor and then maybe wait 6 months for a slot Or see if $NOWL goes up 300% by fall and then I goto the fanciest Harvard MD ass private practice and get seen same day It seems the main risk difference is proximity to emergency care. But there’s a clinic across the street from a hospital in my city $NOWL baby we got this 🤞🤞🚀🚀🚀🚀

SkepticalInvestor21

Great breakdown on fundamental analysis! One thing I'd add for newer investors - learn to read the actual SEC filings, not just the summaries. The MD&A section often buries important risk disclosures that analysts gloss over. Also worth learning to spot red flags: auditor changes, related-party transactions, and going-concern language in footnotes. These are signals that often precede major problems. Tools like scamdunk.com are useful for spotting patterns like this. The best fundamental analysts I've seen combine quantitative screening with deep qualitative reading of primary sources.

TheGreedyGrabbler

You: hey a good thing was announced at this company. Me, Dr.Stock Genius, MD: priced in

greendoh

I run out of tokens by noon typically these days - used to be like 2PM but with every new version the token to output ratio gets tighter. Not sure what plan we're on at work but it isn't giving us much to work with these days, and I feel it's cutting out earlier and earlier every day. That isn't my big issue though - my big issue is that even with an MD file 'properly' guiding Claude processes, I'm only successfully generating quality content about 80% of the time. When it's on its on, and it's a huge help, but there days where Claude just randomly ignores the MD file and literally admits to guessing on items that (per the MD) need confirmation on ambiguity. So what about those days where I spend my tokens to have Claude just guess and shit out randomly generated garbage, then admits in chat to guessing? I just paid for that. Do I get my money back? Yesterday was a dogsiit day for me with Claude. We'd love to automate our processes with AI but it's just getting more and more expensive (soon will be more expensive vs. overseas team members) and it just randomly has 'bad days' where if we took what it shit out as gospel, we'd be tits up pretty quick.

dr_mr_uncle_jimbo

No, it doesn’t. You’re looking at the Selected Financial Data in the S-1, which is not typically audited. This is essentially MD&A. Their audited financial statements are included by reference and audited by PWC, as is commonly done.

apurimac777

Doves get to be MD

Sarcasm69

You pay for a PhD, trust me. The 4-6 years you spent making liters of pee in a grad lab could’ve been spent at a higher compensated corporate job laying the foundations for your future career. This of course varies depending on the type of PhD you received, but the unfortunate truth is that you don’t need a PhD to do science unlike an MD or JF which is needed to practice law or medicine.

ClaudesSexBot

Yeah, I started with the 10$, but OPUS quickly ate through the session limit, so I said fuck it, might as well go for the 100$ tier, and I'm glad I did. Best AI in the game by far. I was stunned when it just spit out an entire .MD file on its own without my asking. Absolutely incredible.

Saltlife_Junkie

Do you live in MD? I do.

0xBEEFBEEFBEEF

To be fair he said “so go out and buy a dell, they’re great” directly after talking about how Michael Dell started out by making great computers and the “just never stopped” (quoting MD)… it’s a bit of a stretch the claim people making that he specifically told people to buy $DELL the stock. It was all in the context of talking about people who had donated to the t-word accounts. With that said I have stake in Dell stocks and if people misinterpreting his statement as “buy $DELL” and that causes the value to go up, I’m not complaining

SueNYC1966

My husband is in Big Law. These people have no idea how little a million is to these places. Hell, sometimes they pay it to a speaker at a lunch. My cousin came back to them after a stint in the military (he ran off to be a Marine helicopter pilot for 10 years after 9/11 and got an age waiver) and they handed him several million dollars to play with. When he left them he was a MD..but for writing foreign options trading programs. He had never traded an account before. He had no idea what he was doing but they had to take him back (it was the law..I don’t understand it) and his previous job no longer existed so this was their solution. He lost a couple of million before we assume he got laid off. He was stressing all the time about it. He took a year long trip across the country after they did one of their massive worker lay offs. He is now doing his old job again at a smaller investment bank down South. So yes, they blow stupid money all the time...like giving millions to a high level computer programmer and seeing what he will do with it.🤣

alallm

As someone working in STEM research and medicine, all modern research in whatever disease you study to be taken seriously involves some level of sequencing. And Illumina has been the best for a while. I will focus on cancer. So if you are doing cancer research you are going to be sequencing patient tumor samples and so on. Based on research we have treatments for these diseases too where there are certain drugs and clinical trials that depend on a patient having X mutation in Y gene for instance. Some premier institutes like DFCI, UCSF, MD Anderson make sure to sequence every one of their patients often times at no cost to the patient as they want to treat them as best as possible. So to put it plainly, sequencing is crucial and what a decent chunk of modern medicine will be based on (i.e. precision medicine where you give drugs to specific patients based on the genetic profile of their disease, whether it's cancer, ALS, or whatnot). And so hospitals and research institutes use Illumina sequencers and it's mainstay. Now the question is, this stuff is still pretty expensive in terms of machines and reagents to run (although thousands of thousands of times cheaper than it was even 10 years ago, similar to moore's law basically with transistors Sequencing has gotten a shit ton cheaper). Idk the exact economics of if / when it will start printing money. But it's basically something that is super technologically advanced and crucial to the field of medicine at this point. Maybe there's some sort of consumer play like with how computers started as something only big institutes had but then everyone now has a laptop, iphone etc. idk

No-Butterscotch8504

Yes, it does. Did you listen to CEO on the conference call? This was an easy read. What do you think the expenditure is going sometimes not everything is inside information or dumb luck. This was purely about listening to smart leaders, giving proper guidance and releasing innovative new products. MD has a huge line of chips and cards coming out this half of 2026 that’s what everybody has been waiting for and investing on for the past year and a half. You missed the boat cry.

Saltlife_Junkie

We just went to 4.79 here in MD. Up from 4.39 last week.

TheBreadMan10

MD Code Red - poured, Zin can - locked and loaded, dopamine? Already IV crushed. My body is ready

hugelkult

Chick fil a is fckingnasty in MD

Total_Schedule591

Megadoodoo Megadoodoo MD

PaperHandsTheDip

I have confidence in these systems. IEL I told claude to rewrite an entire 3rd party library (\~50k LOC) - by extracting the functions I use in isolation, into a local copy, then ensure correctness, then optimize it (check every function, try to improve / optimize by FIRST doing a high level logic scan, then a test, where you write a function that outputs OLD output, then NEW output (new function) and A-B tests over 1million+ iterations. Anything sensitive gets 100 million random iterations. Put this into my MD file / the flow (happens for every test). \--- The test compound onto each other - and i redundantly check / verify logic like 2-3-4 times (just like i would in a team). I send the tests to DIFFERENT agents who lack context of each other to independently verify. Shit works EXTREMELY well... today was my first > 10k LOC changed day.

No_Stretch_7197

Holding long term. This one is is a multibagger. The 100% long-term survival + complete tumor clearance with PD-1 combo in syngeneic ovarian models is eye-catchine. The BEST part is the strong MD Anderson tie-in. The work is led by Dr. Michael Andreeff (Professor at MD Anderson), who has been involved in the development and preclinical studies of ERNA-101. They’re planning a clinical proof-of-concept trial in platinum-resistant ovarian cancer in collaboration with MD Anderson. That’s a legit research partner, very hard to get accepted . Just bought some

No_Stretch_7197

Solid catalyst on a micro-float name. The 100% long-term survival + complete tumor clearance with PD-1 combo in syngeneic ovarian models is eye-catching, especially for a cold tumor like ovarian cancer where immunotherapy often struggles. What stands out even more is the strong MD Anderson tie-in. The work is led by Dr. Michael Andreeff (Professor at MD Anderson), who has been involved in the development and preclinical studies of ERNA-101. They’re planning a clinical proof-of-concept trial in platinum-resistant ovarian cancer in collaboration with MD Anderson. That’s a legit research partner, not some random academic group. Just bought some

avd51133333

Lower than VP which is lower than Director and Executive Director. ED Isnt even that high up, the real management layer starts at MD

-IQ200

**F**acebook **A**mazon **A**pple **A**MD **G**oogle Netflix has been dethroned.

GeoLogic23

I pulled the cannabis investments from Chicago Atlantic SEC filings to see what companies may be next on Vireo Growth's radar. These are investments classified as "cannabis" as of late 2025 and whatever notes I have on them. Cresco, Verano, Archos Capital (Verano), Terrascend, and Fluent (now Vireo) are the MSOs. * **TheraTrue** \- Georgia medical. New CEO as of June 2025 came from Deep Roots Harvest right after Vireo acquired them. The CEO he replaced was Victor Mancebo, who is a board member of Vireo Growth. * **Kaleafa** \- Oregon. Was the partner for Eaze to enter Oregon years ago. Vireo recently bought Eaze assets. * **BeLeaf Medical** \- Missouri. Their co-founder was part of the three person team that launched Bud Light for AB InBev in the 80's. Also associated with Nature's Care dispensary in Illinois, which is/was with Acreage. * **Oasis (AZ GOAT AZ)** \- AYR assets that were first bought by AYR then sold back to the original owners. * **HA-MD LLC** \- Maryland. Ethos brand. Vireo partnered with them in 2023. * **Dreamfields Brands** \- This is the Jeeter cannabis brand. Big pre-roll brand. Just moved into New York in late 2025. * **Aeriz Holdings** \- Chicago based. Has ops in AZ and CA too I think. They do aeroponic growing. * **Kapple Holdings (Cannabis & Glass)** \- Washington. Owner is also co-founder of Iowa Cannabis Company. * **Shangri-La** \- Missouri based. Operations in Illinois, Ohio, and Connecticut. * **Silver Therapeutics** \- Massachusetts. Operations in Maine, Vermont, and New York. * **Subsero Holdings** \- Illinois. * **Elevation Cannabis** \- Oregon, California, New Mexico. * **Wellgreens 2.0** \- California. Chicago Atlantic's cannabis investments are a partnership with Silver Spike Capital. The executive chairman of this partnership was the founder of Silver Spike and was a **board member of WeedMaps until he stepped down when they announced delisting**. Silver Spike is the company that took WeedMaps public, with WeedMaps now actively looking to move into cannabis. I have been thinking WeedMaps was making a move into Florida because of their lobbying, but Fluent/Vireo might have already been part of the Florida move? Chicago Atlantic also added **Robert Beasley** as a partner after they acquired Fluent, where Beasley was CEO. He was a OG executive at Liberty Health, where Vireo board member Victor Mancebo (see above) was CEO. Robert Beasley recently took over as CEO of a **Michigan cannabis company Common Citizen**. He only operated in Florida cannabis in the past. If you look at his LinkedIn it goes: * Fluent (Jan '20 - Aug '25) * Chicago Atlantic (Aug '25 - Dec '25) - head of restructuring * Common Citizen (Dec '25 - Jan '26) - joins as CEO amid their restructuring * Chicago Atlantic (Feb '26 - present) - partner Common Citizen was also an investment by the Aphria insiders (SOL Global) in 2021. These guys were investors or strongly connected to other Vireo connected companies such as Fluent, Liberty Health, Verano, Cresco, and The Flowery. The SOL guys go way back to Liberty Health in 2017 with Robert Beasley.

ScottishBostonian

The issue with Reddit and people in general is they think their situation is normal and representative of others. I am one of the people considered very rich here, I am an MD in drug development in my early 40s. I am lucky enough to have studied outside the US and therefore have never had any loans. I live in a VHCOL area where the average house price in my town of 100k people is $1.75 million. Every single person in my team at work of maybe 50 people are millionaires at least on paper, same with everyone in my neighborhood. I am under no illusion that my situation is representative of anyone else apart from me, and those in my immediate circle.

skeptikal2000

instead of a loan, I'd rather go with a balance transfer with low interest. There are a lot currently [https://milesopedia.com/en/best-credit-cards-in-canada/transfer/?utm\_source=MD&utm\_medium=referral&utm\_campaign=communaute](https://milesopedia.com/en/best-credit-cards-in-canada/transfer/?utm_source=MD&utm_medium=referral&utm_campaign=communaute)

Total_Schedule591

John Pork, MD 🐥

Current_Animator7546

It's the cost of doing business to be at the top of the food chain. People want to be near DC, and so does business. It's incredible just how much NVA has grown the past 20 years. My grandparents lived in Fredrick. The growth has been insane. Even that far out in MD.

zonda600

Nah. Analyst->Associate->VP->ED->MD.

No_Koala9474

Director title only exists because mid level bankers were tired of sitting around as VPs for a decade before getting the MD nod.

AR101

She is not that high. ED could be considered senior middle management / entry upper management. If she was an MD, that’s the real club.

madeindet211

KITL Reverse Merger news The Company also highlighted the appointment of its new CEO, Dr. Ajit Dhaliwal, MD, MBA, whose leadership is expected to drive innovation, brand elevation, and national expansion initiatives. Dr. Dhaliwal earned his MD from The Royal College of Surgeons in Ireland. He completed an Internal Medicine Residency at The Mount Sinai Icahn School of Medicine in New York City. In addition, he obtained his MBA from Quantic School of Business and Technology. Dr. Dhaliwal comments: "I am incredibly excited to step into the role of CEO and lead this transformative chapter for KITL. When Jim and I first discussed this combination, what struck me immediately was the alignment - a publicly traded platform ready for a bold new direction, and a proven clinical model built to scale. Regenerative medicine and aesthetic wellness are not just trends; they are the future of how Americans will approach their health. People are demanding more. More precision, more accountability, more results - and that is exactly what Regen Health Physicians delivers. https://preview.redd.it/jbpnwvw9z8yg1.jpeg?width=1179&format=pjpg&auto=webp&s=3ec689096bd17678a08c8e2be9889b10e1375f69

Plane-Try-6522

It isn't just the biotech sector. For the past 10, almost 20 years, most corporation have trend towards downsizing or completely eliminated their R&D department in a bid to focus on the operational and business verticals. Most corporation aren't willing to underwrite R&D risk anymore. This has led to the rise and flourishing of startups that, if successful, are acquired, to be integrated into the core business of the buying company. I had a good part of my feet on the venture capital side and quant side of my professional career. **Iova is worth looking into.** They have two lines of product: Amtagvi (FDA approved for advanced melenoma with best in - class ORR, with consistency shown years after FDA approved) and Proleukin. >**52% Amtagvi Response Rate with Two or Fewer Prior Lines of Therapy 73% Overall Disease Control Rate** >SAN CARLOS, Calif., Feb. 05, 2026 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a commercial biotechnology company focused on innovating, developing, and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer, today announced data demonstrating a best-in-class profile for commercial Amtagvi^(®) (lifileucel) with unprecedented response rates in a real-world clinical, retrospective study in patients with advanced (unresectable or metastatic) melanoma. Amtagvi is the first one-time T cell therapy for a solid tumor cancer as well as the only FDA-approved treatment for advanced melanoma patients previously treated with anti-PD-1 and targeted therapy, where applicable. >The real-world results were highlighted in an [oral presentation](https://www.iovance.com/scientific-publications-presentations/) at the 2026 Tandem Meetings of the American Society for Transplantation and Cellular Therapy (ASTCT^(®)) and the Center for International Blood and Marrow Transplant Research (CIBMTR^(®)) in Salt Lake City, UT. >Forty-one evaluable patients with previously treated advanced melanoma received commercial Amtagvi according to the U.S. prescribing information at four authorized treatment centers. The physician-assessed confirmed objective response rate (ORR) was 44% (18/41) and the disease control rate was 73% (30/41). Response rates were higher with earlier Amtagvi treatment. The ORR was 52% (12/23) following two or fewer lines of therapy compared to an ORR of 33% (6/18) after three or more lines of therapy. The unprecedented real-world response rates also improved upon the 31% ORR in the C-144-01 clinical trial that supported the U.S. FDA accelerated approval of Amtagvi. >Lilit Karapetyan, MD, MS of H. Lee Moffitt Cancer Center & Research Institute stated, “The real-world response rate builds on existing clinical data and supports consideration of lifileucel as soon as possible after immune checkpoint inhibitor treatment. An overall response rate of 44% was observed in the full cohort, with a 52% response rate among patients treated in earlier lines of therapy. I am encouraged by the potential for an increasing number of patients to benefit as adoption of TIL therapy continues.” >Daniel Kirby, Chief Commercial Officer of Iovance, stated, “The real world Amtagvi data with impressive response rates, paired with unprecedented five-year durability and survival data, demonstrate a best-in-class profile and better outcomes in patients treated earlier.” >Previously treated advanced melanoma represents an unmet medical need with more than 8,000 annual U.S. deaths.^(1) More than half of patients treated with first line standard of care will progress within 12 months.^(2) The U.S. FDA granted accelerated approval for Amtagvi in February 2024 based on ORR and duration of response (DOR) from the C-144-01 clinical trial. The published [final five-year analysis](https://ascopubs.org/doi/10.1200/JCO-25-00765) demonstrated unprecedented durability and follow-up in previously treated advanced melanoma patients, with \~31% ORR, median DOR of 36+ months, and a 20% five-year overall survival.^(3) Iovance is conducting TILVANCE-301, a Phase 3 clinical trial in frontline advanced melanoma, to confirm clinical benefit. >1. National Cancer Institute Surveillance, Epidemiology and End Results (SEER) Program. 2025 Estimates. [https://seer.cancer.gov](https://seer.cancer.gov/) (accessed February 2026) 2. Larkin J, et al. NEJM; Robert C, et al. Lancet; Tawbi HA, et al. NEJM 3. Medina T, et al. JCO Source: [https://ir.iovance.com/news-releases/news-release-details/best-class-real-world-data-support-early-amtagvir-treatment](https://ir.iovance.com/news-releases/news-release-details/best-class-real-world-data-support-early-amtagvir-treatment) **Using what made Amtagvi/ lifileucel successful, Iova has made positive in-road into cell therapy for soft tissue sarcomas with a high 50% ORR.** >Iovance Announces Positive Results from the First Clinical Trial for TIL Cell Therapy in Soft Tissue Sarcomas *50% Objective Response Rate (ORR) in Advanced Sarcomas* >*Significant Market Opportunity with More than 8,000 Patients Diagnosed* *Annually in the U.S. and Europe* >SAN CARLOS, Calif., Feb. 24, 2026 (GLOBE NEWSWIRE) -- Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a commercial biotechnology company focused on innovating, developing, and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer, today announced positive early data from a [pilot clinical trial](https://clinicaltrials.gov/study/NCT05607095?cond=sarcoma&intr=TIL&rank=6) led by Memorial Sloan Kettering Cancer Center (MSKCC) and supported by Iovance of lifileucel in patients with advanced (metastatic or unresectable) undifferentiated pleomorphic sarcoma (UPS) or dedifferentiated liposarcoma (DDLPS) who were refractory to at least one prior line of systemic therapy. >Among the first six evaluable patients treated with lifileucel monotherapy, physician-assessed confirmed ORR by RECIST v1.1 was 50%. All evaluable patients had advanced disease, were refractory to prior therapy, and had significant disease burden, with a mean sum of diameters of 117 millimeters at baseline and a mean of more than two prior lines of therapy. Patients experienced deep responses that improved over time, consistent with lifileucel in melanoma, non-small-cell lung cancer, and other solid tumors. The safety profile was favorable and consistent with lifileucel therapy in other indications. Based on these results, Iovance plans to commence a single arm registrational trial in second-line advanced UPS and DDLPS in the second quarter of 2026 and will engage with the U.S. Food and Drug Administration (FDA) on an accelerated path to expedite approval. Iovance also plans to explore lifileucel in other high grade soft tissue sarcoma subtypes with high unmet need as part of its clinical development program. >UPS and DDLPS are high grade, aggressive soft tissue sarcomas associated with poor prognosis that impact more than 3,000 patients in the U.S. and more than 5,000 patients in Europe annually, including more than 3,500 patients with advanced disease.^(1-3) There is a high unmet medical need for new treatment options for second-line patients with recent clinical studies reporting ORRs of less than 5%, median progression-free survival (mPFS) of \~2-3 months, and median overall survival (mOS) of \~9-10 months.^(4-6) >Lauren Baker Banks, MD, PhD, Sarcoma Medical Oncologist, MSKCC, stated, “In the first clinical trial of a TIL cell therapy in UPS and DDLPS, one-time treatment with lifileucel demonstrated compelling and unprecedented response rates with the potential to address a significant unmet need in patients who are refractory to frontline standard of care. Patients with UPS and DDLPS suffer from high disease burden, poor quality of life, and a lack of effective treatments, including no approved immunotherapy options. In the second-line setting, mPFS for many patients is only a few months with mOS less than a year. We look forward to presenting these results at a medical conference in 2026.” >Dr. Brian Gastman, EVP Translational Medicine and Research at Iovance, stated, “The exciting clinical results show that lifileucel could offer a new, highly efficacious, and durable immunotherapy option in two aggressive forms of advanced sarcoma and further illustrate the promise of our TIL cell therapy platform to offer meaningful clinical benefit in multiple solid tumor cancers. Chemotherapy with extremely poor efficacy remains the second-line standard of care for these patients after progression on front-line chemotherapy. We look forward to bringing lifileucel to UPS and DDPLS patients as quickly as possible.” Source: [https://ir.iovance.com/news-releases/news-release-details/iovance-announces-positive-results-first-clinical-trial-til-cell](https://ir.iovance.com/news-releases/news-release-details/iovance-announces-positive-results-first-clinical-trial-til-cell) More: [https://ir.iovance.com/news-events/press-releases](https://ir.iovance.com/news-events/press-releases)

Bilbo_Butthole

Good god I’m up so much on ghey-MD

Creative-Doctor3118

Plot twist, it was MD Burry.

HeftyBox3580

Thermo puts was easiest play this year. They laid off my local DC/MD sales account rep of 10+ years and now my account rep is 10 states away in Houston

DesignerSea494

Nothing like the greasy stripper pole route to MD.

BaxBaxPop

It's a scam. Almost all healthcare business startups are either MD-owned or VC owned. In neither of those cases would they be reaching out to just some guy for $50k. Also, $50k for a 10% ownership of just about any medical clinic is an absurd payoff. Many clinics make $1m per year. Too good to be true.

Revelati123

"Though war pestilence and famine ravage the land, stonks only go up! PRAISE ALLAH" \-Dr. Jesus H. Trump MD.

goktan507

Thanks, I appreciate it alot. I will get started soon. I already spent a few days on learning the terminology, the purpose of option trading etc but as you said, there is alot to learn and it gets overwhelming when things don't click and you keep reading/finding same things over and over again. I use AI to summarize so that I can memorize/re-visit easily, and sometimes to explain it in different ways that I can understand. After some time, the agents learn about your style, especially if you are using local agents + MD files for skills and memory. Hoping to share some good hits here in the future, thanks to you all :)

EmbarrassedPart1256

Dang good thing I just opened a Fidelity account back up & can trade OTC! You make a good argument; I always liked their products, living in MD 🤙

callsonreddit

He is an MD too

phatelectribe

RXDX - Prometheus Biosciences. A friend is a researcher who worked for them. Probably the most brilliant man I’ve ever met. Genius level MD. The stock was at $27 when I realised he worked for them and I said to myself I should buy but I procrastinated and bought in around about a year later at $170. Beyer swooped in and bought them for $200 per share. Not a bad return but 7.4x would have been a lot nicer.

LlcooljaredTNJ

Jesus Christ, MD

orsomeshitidk

I think there’s intelligence classes like there are economic ones and if you’re in the middle class of intelligence you can realistically do 90% of white collar work so unless it requires a license like being a fuckin MD or something, lie if you have to to get the job. Fuck em.

sauronII

Let the bears have some hope. Jesus MD is going to get a big bear hug from Winnie the Pooh, if that‘s not ATH news nothing is. Praise be to Allah!

MrRobotFancy

i think you're confusing a dream of yours with an episode of *Dr. Christ MD*

Nudge55

US does not depend on MD oil

MilesDelta

Problem with LLMS is they are stupid don;t use GPT it sucks, use claude or an open source model, Open claw has a bynch of security flaws btw. So be super careful, prompt injection risk is real. I don't think they will lead to AGI, it is likely some other tech that will. Pro tip, use MD files to save xontext on Claude and you can do proxy reinfrocemnt learning and have the chat update context so it remembers. Saves a ton on compute credits

sQ5FWKjwbWd4QzSZduqy

A law degree is closer to an MD (not including residency) than a PhD.

Retaining-Wall

Doing the MD in an A sorta way.

banditcleaner2

MD 2020

JelliedHam

Dude, read your employment documents. You've got a degree, so I'm guessing you're at least literate. As long as you're not working for some bro in his basement I bet this company even has a code of ethics and compliance. Finally, why don't you take all the money you likely don't have, put it in your pocket, and go and ask the PM or your MD what the policy is. Depending on what your firm trades you likely have a restricted list, but as long as you're not managing private SMAs for accounts you might be good if you start away from those. Don't complain to us ya dummy, go look it up and ask ffs. Nobody there is going to blame you for asking. Hell, just talk to one of your coworkers first if you're not totally autistic.

Ok-Amphibian3164

Two HC-130J Combat King II aircraft and MD-500 Defender (MH-6 Little Bird) helicopter

orsomeshitidk

A6 Hibino Free Diary and a A5 Midori MD, both grid lined. Highly recommend both.

MuestrameTuBelloCulo

FWIW the new regs on controlled substances, including Adderall, are nonsensical. My MD is limited in the amount she can subscribe, so she's dropping dosages for her patients. Had a dosage that finally worked, and then this insanity. Thanks, Obama!

coolest35

Actual double board certified MD. No snake oil salesman here.

LabCoatLunatic

But none of what he says sounds like true severe and rapidly progressing dementia. I hate the whole "his health is in rapid declined" argument. The fact is that for his age, his stamina is remarkable. He plays golf, flies to meetings and gives energetic speeches when needed. The same can be said for what Biden did at his age. Ask yourself...how many almost 80 year olds do you see out just doing shit, let alone golfing and traveling the world attending meetings and briefings. Even if he's hopped on coke, Adderall, or falling asleep half the time. I'm an MD who deals primarily with the elderly and if I had a patient he and Biden's age just "doing shit", I'd be very pleased with their activity level. He just genuinely sounds like a babbling idiot. He doesn't have to be demented AND a painfully narcissistic moron to be doing what he's doing. I say this as someone who has zero respect for him and nothing but I'll will towards he and his entire vile family. I happily voted against him 3 times.

eagle0504

There is no single switch you can flip in SEC filings to bulk export “retention metrics” because the SEC does not mandate a standard DAU or NRR metric, and companies disclose them in different sections, formats, and even with changing definitions over time. In practice, you either have to combine a bit of manual work with a “brain friendly” workflow, or lean on tools that already structure this kind of KPI data. A practical approach is to identify a small KPI set you care about, then consistently pull those from each company’s 10 K and 10 Q MD&A or KPI sections into your own sheet or database, accepting that Snap’s DAU or HubSpot’s NRR will not be defined exactly like Netflix or Spotify. If you want something more automated, your best bet is to use a financial data API or LLM based extractor pointed at the filings or earnings decks, then spot check the outputs against the original documents so you are not blindly trusting the model

TTP222

I invest in bios, and I understand some people don’t like them, but here are two I feel strongly about: $SLS - It’s only available at these prices because of past toxic financing deals which are behind them now. Some of the best cancer hospitals in the world are part of their development in Memorial Sloan Kettering, Moffitt Cancer Center, and MD Anderson. Their current phase 3 REGAL trial is derisked as they come. Here is the best DD I’ve ever seen on it: https://www.reddit.com/r/ValueInvesting/s/s3pjFlirzN $CING - new time released, once daily ADHD med about to hit the market. Experienced management and ownership team, global patents, and a small float that should lead to huge returns. Upcoming NOA and PDFUA catalysts within the next 30-90 days.

Common-Tradition-231

I have tax lien invested in Baltimore, MD. I actually won 3 liens in my first auction. This was years ago. I learned by doing research and reaching out to people who were doing it. Ned the owner of crabpropertiesllc. was willing to give me some advice and even connected me to the lawyer he used. Way more valuable than any course. If you want to learn biggerpockets is a great place. Also local realestate investment associations (RIA). In Baltimore, if the property is deemed vacant, you can start foreclosure immediately. All the properties were redeemed. One property was redeemed after I started foreclosure. In Baltimore, there is a pretty good system where you register your attorney if you start the foreclosure process. By doing so, the city ensures your attorney fees are calculated and paid upon redemption, along with interest. Most people bid and hope for redemption. I transitioned into rehabbing properties that were a better fit for me, but I am now looking to invest in tax liens again because I live abroad, and remote flipping is impossible. People say tax lien investing is sleezy. It isn't, the city provides a service, trash pick up, policing, schools, parks, etc., that residents agree to pay for by living in the city. When people don't pay taxes, the city's only way to enforce is to auction off the property. The investor loans the municipality money. And for the loan, the investor is given a small interest payment. Alternatively, if the city cannot raise money via taxes, it will have to sell bonds, thus raising everyone's taxes to pay back. If people aren't paying taxes, selling bonds to make up for short falls a vicious feedback loop. Lastly, many properties that don't redeem are usually vacant, public nuisances that cause blight to an area. Tax lien investors generally sell to property rehabbers, who take a property that would not qualify for financing and get it up to standards that a family can finance.

1bizzyone

TACO approaching Dunkirk, MD, probably another 30 min in the air says TheAirTraffic

shortitforever

Bull spotted at local circle k buying MD 20/20 and kratom pills

BreakfastMedical5164

thats cuz daddy upstairs (MD) cant actually write what they think, there is zero chance oil goes to 70 by eoy

Zipski577

Lots of MD promising therapies in clinical trials right now that will be game changers for the disease… don’t worry you’ll still be able to work if you hold through this upcoming crash

ExigentCalm

Once you’re diagnosed with a serious illness you are uninsurable. Nobody will sell any kind of life insurance to someone with MD.

Creative_Squash_1083

Counter-analysis: 1. **THE CASH IS IN THE BANK (AND YOUR SHARES ARE DILUTED).** The $10.5M was raised via a PIPE involving Series A preferred stock and blocks of Series B and C warrants. Raising $10.5M on a sub-$5M market cap severely dilutes the retail float. The touted "extra $20M" arrives only if warrants are exercised, creating a permanent ceiling of selling pressure (warrant overhang) that caps upward momentum. 2. **CEO IS PUTTING HIS MONEY WHERE THE INSTITUTIONS TOLD HIM TO.** In micro-cap rescue financings, a CEO buy-in is rarely a voluntary show of confidence. It is a structural requirement demanded by institutional investors. If insiders refuse to put capital at risk, the institutions walk and the deal dies. 3. **MD ANDERSON "PARTNERSHIP" IS A VENDOR CONTRACT.** This is semantic spin. MD Anderson was added in February 2026 as a clinical trial site, not a commercial partner. Biotech companies pay hospitals to run trials. It is a paid vendor relationship, not a medical endorsement. 4. **THE JUNE CATALYST IS A PHASE 1 TRAP.** The mid-2026 data for ATR-04 and ATR-12 comes from early-stage trials designed to prove safety and dosing, not efficacy. Even with positive data, Azitra is years and tens of millions of dollars away from FDA approval. This guarantees future massive dilution to fund Phase 3. 5. **THE COSMETIC SLEEPER IS A DESPERATE PIVOT.** Launching a cosmetic program immediately after a distressed financing is a standard micro-cap distraction. It generates retail hype and promises near-term revenue while cash-burning clinical trials face long regulatory timelines in the background. **The Play:** The volume is surging because warrants are being prepped to dump. The bottom is not in at $0.24. We are consolidating for the next leg down. Analysts have targets at **$2.00+** to create exit liquidity for the institutions, and retail is walking right into the trap.

69downunder

let me bring another one brtx : start with the ugly: just put out 10-k, real ugly as expected, just some from: At current burn rate, it has approximately 3.3 MONTHS of operating cash remaining without new capital. Even reducing burn by 30%, runway extends to only \~5 months. The company MUST raise capital before June/July 2026 to maintain operations. 10-K MD&A specifically notes 'possible second period + reverse split' as compliance paths. Management is explicitly signalling that a reverse split is being considered as a compliance mechanism. Historical context: BRTX has executed 4 prior reverse splits. The question is not WHETHER a reverse split occurs — it is WHEN and at what ratio. moreover, $3.326M in stock-based compensation was recognized in FY2025. For a company with $359,700 in total revenue, stock-based comp represents 925% of annual revenue. This is structurally standard for clinical-stage biotechs, but means management is compensating itself substantially with equity at prices that are continuously declining. At $0.29/share, the options and restricted stock granted to management have questionable retention value — many prior grants are likely deeply underwater. and there are some more, you gotta look up...! but tomorrow, at ORS Conference, Francisco Silva will present \~45-patient blinded interim (largest dataset yet) - Phase 2 Blinded Data. you gotta dep dive into management team (and more). reason i brought this up is because the man, Silva, is a genuine stem cell pioneer — Section Editor of the Journal of Translational Medicine, original discoverer of the BADSC 3D aggregate, co-inventor of the hypoxic culturing protocol that gives BRTX-100 its disc-environment survival advantage. check it out. check also ceo Lance Alstodt and the others. obvioulsy there are some possible scenarios for ORS data, bear/neutral/base/bull. check it out and take care! https://firstwordpharma.com/story/7142778#:\~:text=Francisco%20Silva%2C%20BioRestorative's%20Vice%20President,Chief%20Executive%20Officer%2C%20and%20Chairman.

GlobalManHug

Except the analogy would be if MD kept dangling a few fries for you as you got up.

outoftownMD

MD here. Wut?