PK

RibeyeAndScotch

Anybody know why did they give Kane another PK???

Kitchen-Raccoon4572

https://www.youtube.com/watch?v=PK-sHqa-sMk

ZeeBeeblebrox

IR and PK both signaling that no one from IR is going to be there.

UnknownM007

Fully expecting a tweet from the PK PM saying the Iranian delegation arrived safely and are ready to negotiate and SPY will pump again

Left-Associate3911

This is not a surprise at all. Israel is manipulating Trump for its own benefit and Trump is using the failed state that is PK to make him look like the strongman he thinks he is. It is truly a puppet merry go round of the deluded and dysfunctional.

UnknownM007

I’d love to see the PK governments international call phone bill. Must be through the roof with all this diplomacy

GenFokoff

Trump suggest PK PM to ask him this. The real script.

MaybeYesMayb

I’m going to come and PK you

14mmwrench

Yup, but rocket artillery is even worst than gun base systems for beaten zone. It could work but the PK will be silly low and they will lose the launching equipment.

14mmwrench

CIWS can do that if it is small enough and has bled off enough air speed. But that is a limited self defense weapon and irrelevant to the discussion. If you are not familiar with the term counter battery fire you need to brush up on your military tactics a bit. Country battery fire attacks the archer not the arrow. A single gun firing 10 NM in to the straights even right on the shore line has a very low probability of a first shot hit, and this is a direct fire shot. Minimum salvo size to get accurate ranging data is around 4, a single gun battery especially if not designed with and using an advanced fire control system will really suck at this, because any small variance in projectile weight, powder charge or atmospheric conditions will cause large variances in impact point. Modern tube artillery can really stretch its legs and they could move the batteries 10NM inland. But then they would need an entire section of guns, and its baggage train to have a dense enough beaten zone around the ship to get hits. The increased range greatly complicates the solution, because the flight time is almost a minute, the rounds are flying high enough to cause concern for civilian air traffic and you know how bumpy it can get up there. It would take at least one ranging salvo to be able to bracket the target, and then you have to make enough hits to cause serious damage. Tanker ships are not slow, I have seen them trucking along at 22 knots, and you would have to continue to traverse the gun to stay on target, the ship could have moved up to 1/3 of a N mile in the flight time of your projectile. You would also need an observation system to radio in adjustments, or have your own spotting aircraft up. Emitting RF also causes its own set of problems. Modern radar systems can math out the likely place the incoming originated from. Then the warships can return fire with their own artillery systems that typically have a much higher rate of fire and a better fire control system, or use short range missile systems if possible. Or use their aircraft to ID the target, and vector in any armed aircraft in. I doubt there are many artillerymen alive today that spent much time training on moving targets over water. Artillery is not a viable offensive weapon against shipping when you do not have air superiority, unless you are willing to completely sacrifice the weapons system and personal for a low PK. Drones work both directions and loitering armed drones could put an end to it quickly

iThinkiStartedATrend

[I don’t like to gloat](https://www.reddit.com/r/wallstreetbets/s/PK9knoycKn)

FlashSTI

It already is. On rare occasion some mid skill with 10 years of doing mostly the same job thinks they can argue with me in some of my areas of deep deep proficiency. I do try to warn them, but they will insist that their proxy auto numbered PK is important despite being in a derived data store that only exists for reporting, no clue what a compound natural key is, why foreign keys are typically indexed by default and that every data field doesn't need to be NVARCHAR MAX muthafuckah so I won't even try to explain partitioning...sigh

Express-Mongoose-738

Vk-2735 beats tirzepatide at every level Preclinical better liver fat reduction in mice ( Vk 2021 ) In primate better PK qualities ( longer t1/2 and longer t max ) translates into higher exposure and more wt loss in primates for vk2735 at equivalent doses. ( Vk slides ) In humans, when looking at VK 2.5 mg for 12 wks it beats tirzepatide that’s escalated 2.5-5-7.5 mg .. also modeling wt loss based on serum leveled and previous clinical data show better wt loss with VK https://preview.redd.it/9e8u6midkjjg1.jpeg?width=2868&format=pjpg&auto=webp&s=a5cae92c3a71ffc026d10da07a4f6f597d383379

Own-Employee9468

I think the initial drop was investors being worried the deficiency was related to the drug, but because it's just human error from the packaging (because it's for anaphylaxis, ease of access needs to be very stringent due to the life and death nature of it), it's a MUCH cheaper trial to run, and they already have the bulk of the PK data to support it. It kind of makes sense, the market thought the deficiencies could've been worse than they actually are. I'll see whether this comment ages well when market actually opens xd

Own-Employee9468

AQST announced receipt of a CRL for Anaphylm, FDA cited human factors (ease of opening packet + placement of film within packet) and have asked for supportive PK data to show that any adjustments to this won't impact efficacy.

skrabytomo

* **Traditional drug discovery** * \~**90–95% failure** from discovery → approval * Most failures happen **after synthesis** (toxicity, efficacy, PK) * **AI‑assisted molecular design (current)** * **Design → synthesis success:** \~**70–90%** * Meaning the molecule can actually be made and is stable * **Synthesized → biologically functional:** \~**30–60%** * Depends heavily on target and assay * **Clinical success:** still brutal — **\~85–90% fail**, same as traditional Key difference is **where the failures move**: * Before AI: ❌ Huge waste on *unsynthesizable* or obviously bad molecules * With AI: ❌ Failures concentrate later (biology, toxicity), not chemistry # Cost impact (rough order‑of‑magnitude) * Lead discovery phase: * **Traditional:** tens to hundreds of millions * **AI‑driven:** often **10–50× cheaper** * Time: * Years → **months or weeks**

Own-Employee9468

Anyone been watching AQST? They dropped from around $6 to $3.50 on 9th Jan. when they disclosed FDA identified deficiencies on a form 483, and have slowly bled down to sub-$3 since then. Was thinking of getting in if it dips on delay or CRL news, top-line PK data looks really good despite FDA concerns and they have $120mil cash to last a year or so.

Aggravating_Fig6288

Gonna have to go PK in the wildy to make my losses up today

ElmoLovesGrover

In this morning for 20,000 at 10.7 cents. Their news is that they are waiting to see if FDA lets them use the 505(2)b pathway to get FDA approval for their sublingual aspirin. If they get approval then they don't need (in the best case) to perform any additional studies beyond the PK study(ies?) they have already performed. They could also get approval, but FDA could still ask for one or two more small PK or bridging studies. If feedback from FDA allows, then they will be able to file the NDA (not IND) in second half of this year. Considering that its aspirin, and their PK data is good, FDA should allow. But... this is FDA. Nothing is sure with FDA and FDA regularly throws out curveballs.

Nuggets_Bt_Newer

I aim for a credit of ~2 and the loss when it touches ends up being around 27-34 depending on how quickly the stock touches. I.e if it dropps 100$ in 3min it will cost more than a gradual drop. That being said its only touched on 1.3% of my total trades making that ~30$ cost something like 0.39 (Loss*%chance of losing) and the premium usually ~1.94 if you look at it from cost to odds valuation. (Premium*% chance of winning) I know PK doesn't like the terms winning and losing, but it's the best way to verbalise my strat.

Axwe8

**Breaking News:** **🥭** spotted **PK'ing** Maduro in the **Wilderness**

Axwe8

**Breaking News:** **🥭** spotted **PK'ing** Maduro in the **Wilderness**

Axwe8

**Breaking News:** **🥭** spotted **PK'ing** Maduro in the **Wilderness**

ShockRods20

Every time I get PK’d in ARC Raiders, I remind myself I hold RKLB and it makes me feel better.

OneDayButTwoDay

Can we still PK in the wilderness for bankrolls?

cantgetthistowork

I could repost this every Thu before opex https://www.reddit.com/r/wallstreetbets/s/kBL8PK5RSw

Chill-Dragonfly77

Alright I’ll bite. But only replying once.  This isn’t how I FEeL. Stop doing strawman arguments. This is based on real events happening in the world that are eroding trust in government transparency and data. Just because you don’t like hearing doesn’t mean, and I’ll use your own words, that you get to bury your head in the sand and go “la la la” everyone is stupid besides me. Usually the most ignorant people are the most confident. Yes I’m looking at you.  So let me give some sources, I look at what’s happening:  https://itep.org/trumps-firing-of-bls-commissioner-is-part-of-larger-erosion-of-federal-data-infrastructure/ “Last week, President Trump fired the Commissioner of the Bureau of Labor Statistics (BLS) in retaliation for publishing weak jobs numbers in the Bureau’s monthly employment report. The Trump administration rightly received criticism for spooking investors and undermining the credibility of government data for this reckless move. But this is just the latest act in a broader erosion of the federal data infrastructure.” https://www.theguardian.com/business/2025/sep/17/labor-statistics-chief-trump-erika-mcentarfer ““Markets have to trust the data are not manipulated,” said Erika McEntarfer, the former head of the Bureau Labor of Statistics, in her first remarks since her firing. “Firing your chief statisticians for releasing data you do not like, it has serious economic consequences.” https://www.wsj.com/economy/bls-to-skip-october-ppi-report-cefc4ef1?gaa_at=eafs&gaa_n=AWEtsqcey7RXj_wkUhfs7FXSwcyT4I4A-WuxJtZdpazhvcbopqWTYQX5wLDLwNdOzYI%3D&gaa_ts=6939f7c6&gaa_sig=HllOqSp1KPXNJ0ti8NJIcbltHICq83gtKFAEZyjM-Mev3fQ1PK0mIOCqdGA0zIFGNIFbGbQHB5LSdSO4oSEj2g%3D%3D “The Bureau of Labor Statistics will skip publication of its delayed report on wholesale-price inflation, and will instead roll those figures into a postponed November report to be published on Jan. 14, the agency said Monday.” Once/IF they start indefinitely delaying data sets or if the numbers don’t roughly match private sector estimates it’s going to be a big problem.

Sensitive_Pilot3689

OP wrote all that to let us know he’s a retarded noob. It’s ok we all get PK’d once in a while

MediumSinger8088

Ambroxol is apparently a mucolytic that stimulates lung surfactant production and physically interacts with components of mucus - I admit I wasn't familiar with it. The structure doesn't look very CNS-penetrating, and PK would be fast, due to glutathione conjugation at those bromine centers. It may have tangential effects on lysosomes or autophagy but likely not direct effects based on engagement with specific proteins which major investors want. IMO chief competition / synergies of 02287 are LRKK2 inhibitors being developed by Neuron23 (private) and Sanofi. GCase and LRKK2 pathways converge at the lysosome or autophagolysosome (mitochondrial digestion) so these are complementary drugs.

waliving

Time to PK in RuneScape then clean the house then go to a sauna

CryptoApeNL


blalah

Yeah, I don't disagree with you there, using CB or a broker is easier and in some cases far safer than trying to track your own keys. My point was more that crypto is intrinsically different in that there is still a PK, no matter who is holding it, or how many times it's stored or backed up. If that's gone, it's gone. With forming a company and issuing stock it's just a matter of getting the execs and the lawyers in a room for an hour while everyone bangs their dicks on the table and the lawyers leave paid. There's nothing that could make the stock suddenly disappear.

blalah

Would love to see one of these massive ETF holders lose their PK lol

cashflowyield

[https://youtu.be/n\_pRD\_gMy1A?si=PK63pXShXZ7oI0-N&t=5103](https://youtu.be/n_pRD_gMy1A?si=PK63pXShXZ7oI0-N&t=5103)

Many_Easy

I’m long this industry, particularly Tilray Brands. Don’t assume anything. I don’t own any puts or short this industry. As far as soon, he passed that “few weeks” timeline plus he breaks most of his “promises” anyways. POTUS has not made any promises-cannabis promises anyways. PM ≠ PK.

Goopstains6318


reaper527

don't really have one because i'm still in "rebalance my portfolio" mode (and i do that through new purchases, not selling off stuff for the sake of diversifying). UNH and AMZN are my current big "keep buying them" things right now though. (was PK a few months ago until i hit my target for how much of my portfolio i wanted to be real estate)

Electrical-Goal-4163

I found the ticker OVID and the buy rating caught my eye. Asked GTP about any catalysts and this came up. Key Upcoming Catalysts & Their Sources 1. OV329 (GABA-aminotransferase Inhibitor) Phase 1 topline safety, tolerability, and biomarker data expected in Q3 2025 . Phase 2a trial initiation in Q1 2026, with topline results anticipated Q1 2027 . 2. OV350 (First-in-human KCC2 Direct Activator, IV Form) Safety, tolerability, and PK data expected in Q4 2025 . 3. OV4071 (First Oral KCC2 Direct Activator) IND‑enabling studies are underway; first‑in‑human (Phase 1) studies are expected to commence in Q2 2026 . According to the August 2025 corporate presentation, Phase 1 initiation is planned for Q2 2026, with a Phase 1b in patients expected Q3 2026, and topline results by Q1 2027 .

BeneficialSort9477

Interesting one... makes me wonder why they didn't look at plavix too -- this can potentially mitigate the risk of GIB + minimize the first pass effects which is especially important for plavix since hepatic enzyme genotypes significantly impact plavix PK and efficacy?

granddaddychino

Thanks for checking it out. I went ahead and created a brief video. https://youtu.be/Ypfo3eybn6I?si=T-4BuAV7iWMs7PK4

ProfitableFrontier

VT - it's the world Vnqi - land abroad Vnq - land in the US SPSK - Sukkuk as a bond alternative PK - Yolo'ed some money into it a few years ago

snuepe

READ the crash investigation report, no newspapers, no youtube, no netflix. Read the report. And for a short one you can read my comment below. https://www.aaiu.ie/sites/default/files/FRA/2018%20-%20035%20-%20PK-LQP%20Final%20Report.pdf

Dizzy_Maybe8225

| REIT Name | Ticker | Buyback Amount | P/E Ratio | Dividend Yield | Analyst Rating | Market Cap | |-------------------------------|--------|----------------------------|-----------|----------------|----------------|-----------------| | Alexandria Real Estate Equities | ARE | $212.9 million | 23.71 | 7.59% | Hold | $12.04B | | JBG Smith Properties | JBGS | $187.5 million | N/A | 4.06% | Sell | $1.26B | | Host Hotels & Resorts | HST | $100.0 million | 16.08 | 5.16% | Moderate Buy | $10.89B | | Park Hotels & Resorts | PK | $47.3 million | 17.11 | 9.65% | Hold | $2.07B | | Apple Hospitality REIT | APLE | $29.6 million | 14.68 | 8.28% | Moderate Buy | $2.77B | | RLJ Lodging Trust | RLJ | $23.9 million | 28.81 | 8.22% | Hold | $1.10B | | Realty Income Corp. | O | Authorized up to $2.0 billion | 41.70 | 5.69% | Overweight | $51.10B | | Global Net Lease | GNL | Authorized up to $300 million | N/A | 9.79% | Moderate Buy | $1.73B |

Dizzy_Maybe8225

| REIT Name | Ticker | Buyback Amount | P/E Ratio | Dividend Yield | Analyst Rating | Market Cap | |-------------------------------|--------|----------------------------|-----------|----------------|----------------|-----------------| | Alexandria Real Estate Equities | ARE | $212.9 million | 23.71 | 7.59% | Hold | $12.04B | | JBG Smith Properties | JBGS | $187.5 million | N/A | 4.06% | Sell | $1.26B | | Host Hotels & Resorts | HST | $100.0 million | 16.08 | 5.16% | Moderate Buy | $10.89B | | Park Hotels & Resorts | PK | $47.3 million | 17.11 | 9.65% | Hold | $2.07B | | Apple Hospitality REIT | APLE | $29.6 million | 14.68 | 8.28% | Moderate Buy | $2.77B | | RLJ Lodging Trust | RLJ | $23.9 million | 28.81 | 8.22% | Hold | $1.10B | | Realty Income Corp. | O | Authorized up to $2.0 billion | 41.70 | 5.69% | Overweight | $51.10B | | Global Net Lease | GNL | Authorized up to $300 million | N/A | 9.79% | Moderate Buy | $1.73B |

WenMunSun

My god bro wtf are you talking about... i'm an American and i used to own BYD in 2009. It's called the OTC market, ticker [BYYDF.PK](http://BYYDF.PK) Americans CAN own BYD and have always been allowed to own BYD. Back to for you

AppleTree98

The FED straight up created magical funds to make the who SIVB and SBNY members whole. Go ahead and look it up. Ok i'll grab a quick search. * [**Guaranteed Deposits**](https://www.google.com/search?cs=1&sca_esv=f24ca8b027933cc4&sxsrf=AHTn8zrqGwhiqd7gG1WlC-eHPMRu9HtZKg%3A1747882205154&q=Guaranteed+Deposits&sa=X&ved=2ahUKEwj3mo3PiLaNAxW2DEQIHb9zCAwQxccNegQIEBAB&mstk=AUtExfBy5ZqJQT9PQgVHePRpqUqU10kmIftdTxVZWqpni1UwpcRgzUNpWhy0kuoDBp8ndsf4hbNJtG6ewYg4qN0bHvdzBImZwPVx9skqotLuA4rktLckT_GYZoOujmIhcRTUuG5PK6lfva7SNfIoSeFm-NSkd05S8hyifN2A-GMRKxFomeQ&csui=3)**:**.Opens in new tabThe FDIC, along with the Federal Reserve and Treasury, guaranteed all deposits at SIVB and SBNY, including those exceeding the standard $250,000 FDIC insurance limit. This meant depositors, regardless of their deposit amount, would receive their full funds.  * [**Liquidity Support**](https://www.google.com/search?cs=1&sca_esv=f24ca8b027933cc4&sxsrf=AHTn8zrqGwhiqd7gG1WlC-eHPMRu9HtZKg%3A1747882205154&q=Liquidity+Support&sa=X&ved=2ahUKEwj3mo3PiLaNAxW2DEQIHb9zCAwQxccNegQIExAB&mstk=AUtExfBy5ZqJQT9PQgVHePRpqUqU10kmIftdTxVZWqpni1UwpcRgzUNpWhy0kuoDBp8ndsf4hbNJtG6ewYg4qN0bHvdzBImZwPVx9skqotLuA4rktLckT_GYZoOujmIhcRTUuG5PK6lfva7SNfIoSeFm-NSkd05S8hyifN2A-GMRKxFomeQ&csui=3)**:**.Opens in new tabThe Fed created a new [Bank Term Funding Program (BTFP)](https://www.google.com/search?cs=1&sca_esv=f24ca8b027933cc4&sxsrf=AHTn8zrqGwhiqd7gG1WlC-eHPMRu9HtZKg%3A1747882205154&q=Bank+Term+Funding+Program+%28BTFP%29&sa=X&ved=2ahUKEwj3mo3PiLaNAxW2DEQIHb9zCAwQxccNegQIJBAB&mstk=AUtExfBy5ZqJQT9PQgVHePRpqUqU10kmIftdTxVZWqpni1UwpcRgzUNpWhy0kuoDBp8ndsf4hbNJtG6ewYg4qN0bHvdzBImZwPVx9skqotLuA4rktLckT_GYZoOujmIhcRTUuG5PK6lfva7SNfIoSeFm-NSkd05S8hyifN2A-GMRKxFomeQ&csui=3) to provide liquidity to other banks, helping them meet depositors' needs and prevent further bank runs. This program offered loans backed by collateral to eligible depository institutions.  * [**No Taxpayer Funding:**.Opens in new tab](https://www.google.com/search?cs=1&sca_esv=f24ca8b027933cc4&sxsrf=AHTn8zrqGwhiqd7gG1WlC-eHPMRu9HtZKg%3A1747882205154&q=No+Taxpayer+Funding&sa=X&ved=2ahUKEwj3mo3PiLaNAxW2DEQIHb9zCAwQxccNegQIJhAD&mstk=AUtExfBy5ZqJQT9PQgVHePRpqUqU10kmIftdTxVZWqpni1UwpcRgzUNpWhy0kuoDBp8ndsf4hbNJtG6ewYg4qN0bHvdzBImZwPVx9skqotLuA4rktLckT_GYZoOujmIhcRTUuG5PK6lfva7SNfIoSeFm-NSkd05S8hyifN2A-GMRKxFomeQ&csui=3)The FDIC emphasized that no taxpayer money would be used to cover the losses associated with SIVB and SBNY. The FDIC's [Deposit Insurance Fund](https://www.google.com/search?cs=1&sca_esv=f24ca8b027933cc4&sxsrf=AHTn8zrqGwhiqd7gG1WlC-eHPMRu9HtZKg%3A1747882205154&q=Deposit+Insurance+Fund&sa=X&ved=2ahUKEwj3mo3PiLaNAxW2DEQIHb9zCAwQxccNegQIIBAB&mstk=AUtExfBy5ZqJQT9PQgVHePRpqUqU10kmIftdTxVZWqpni1UwpcRgzUNpWhy0kuoDBp8ndsf4hbNJtG6ewYg4qN0bHvdzBImZwPVx9skqotLuA4rktLckT_GYZoOujmIhcRTUuG5PK6lfva7SNfIoSeFm-NSkd05S8hyifN2A-GMRKxFomeQ&csui=3) (DIF), which is funded by assessments on banks, would be used to cover any losses. 

reaper527

still love the companies i picked up when first entering the market in 2020 (PEP, MO, IRM, XOM, IBM, T), the last few weeks have been picking up PK (a REIT)

reaper527

> anyone buying this week? * bought some PK (real estate was under-represented in my portfolio and i'm in the process of rebalancing as i make new purchases) * closed my january 2026 csp on intc $20 (10 contracts, net profit ~50%) * opened a csp on UNH at $310 for 7/18 (1 contract) view UNH as a risky play, but with an almost $22/share premium i'm reasonably confident that position closes out in the green in a few months

Yorokobi_to_itami

[oh yeah they have great fundamentals ](https://youtube.com/shorts/h05XLFbHl3o?si=a1yAEy5vP8VS4QS9) [I couldn't think](https://youtu.be/IQJL3htsDyQ?si=6k5vGwyLgtLkE9TK) [of a single](https://youtu.be/46bOzXx2iZI?si=-E0jZ5qvWZ6yDdwz) [thing that would](https://youtu.be/PK_EJ3DyiiA?si=Yt9d5nwCo4xO_2yJ) [Make people](https://youtube.com/shorts/uVSZ7KMJKWg?si=V71X3j_yK0tkMHtk) [people think that](https://youtu.be/Z-qWmlYm_bE?si=QgHcfFIw4_toDD0J) [think Tesla ](https://youtube.com/shorts/6AudXd_1YaI?si=MFDsDLlM1zrqh9JQ) [or any of elons](https://youtu.be/-KneSpxzvFg?si=ZbBfEyu1D_7gXtzC) [products are faulty](https://youtu.be/gai1buBArmM?si=D0t7fe3RWw9TFZzo) [I mean seriously it's not like all his products are shit](https://youtu.be/K5vDWhMHTwE?si=1D5ZkYotR6UYqohL)

sleepyspar

PK?  0002? Is at least one of those real?

aeternus_hypertrophy

Oh boy wsb is gonna be spicy while this kicks off. Half this post's comments are like 3 users who frequent either IN/PK related subs

Josepth_Blowsepth

$1 says China is behind the Pakistan escalation of India threatening nukes. China will step in and get both countries to settle down. Look good in the process and diminish the US role and make themselves look level headed and not a chaos monkey. They need PK to stay intact for CPEC and do not need to deal with the fallout of a war. Will get a bit more heated and Xi will step in. Markets will run faster then a loose pig in a Hong Kong alleyway.

chiisushedjiddb

I’m Bon at 0.14. Made some good money playing the PK spikes!

TingGreaterThanOC

Yes  https://m.youtube.com/watch?v=PK_EJ3DyiiA?t=18m30s

MorrisseysRubiksCube

PK Ripper

Infinite_Prize287

Bought more PK today for the first time since 2020, then noticed that PFE has the same dividend, so I bought some more shares and $30c for June 

Forward_Ant_9074

Thanks for your insight! I’m no longer planning to buy more; comments around here changed my mind quite a bit w.r.t hotel REITs in general I’ll just be keeping my current PK stash until the difference between stock valuation and their hotels’ replacement value decreases to <1.5x or so. Right now it’s like 2x, so it’ll likely require buybacks as discussed in their recent call

Forward_Ant_9074

Thanks, agree, I’ll not be increasing my position. Will decrease it to 25% or so when PK is at my breakeven (+5% from current price). Appreciate your comment

dvdmovie1

"Currently my 40% portfolio is $PK" I would never put 40% of my portfolio in anything, but particularly a hotel REIT which get absolutely obliterated any time there's the slightest slowdown. I mean, look at BHR, APLE, DRH, AHT, SOHO, PK, PEB and others - all hotel REITs, all still below or well below where they were in 2019 and eventually we're going to have a recession again. This subsector of REITs really does have kind of a terrible track record and you'd be better off just investing in MAR/HLT. Is PK cheap? Sure. It's definitely cheap but we've had this period where travel has been back and it just keeps eroding. Where's it going to be when things do actually start to turn South in the economy? I mean, PK has been a public company now for close to a decade and the share price track record is -55%. Good luck to you and hope you do well but I can understand 2-3% to this as a value play but definitely not 40% or anything remotely close to that. You have a sector of REITs that hasn't really done all that great when times are good and then gets obliterated the moment things turn South.

OpportunityDue90

No not even close. Generics are almost identical to brand products and must be on a population level. [It’s true that the PK values are required to fall between 80% and 125% of the reference value in these randomized, crossover trials. More importantly, however, the entire 90% confidence interval (CI) of the observed PK value must also fall between 80% and 125%. As a general reminder, CIs are ranges of values we can be confident the true result falls, which in this case is 90% of the time.](https://www.pharmacytimes.com/view/debunking-a-common-pharmacy-myth-the-80-125-bioequivalence-rule) The same is true for AUC which is exposure to the drug.

slowlearner890

If PK was a great buy then, it is a screaming buy now.

BULLSONYA

RXRX to report: Phase I monotherapy safety and pharmacokinetic and pharmacodynamic (PK/PD) data for REC-617 on Dec. 9 during the American Association for Cancer Research special conference in Toronto - RXRX has a 20 billion pipeline guarantee. Leader in AI drug development, and just bought their competitor.

BULLSONYA

RXRX to report: Phase I monotherapy safety and pharmacokinetic and pharmacodynamic (PK/PD) data for REC-617 on Dec. 9 during the American Association for Cancer Research special conference in Toronto - RXRX has a 20 billion pipeline guarantee. Leader in AI drug development, and just bought their competitor.

BULLSONYA

RXRX to report: Phase I monotherapy safety and pharmacokinetic and pharmacodynamic (PK/PD) data for REC-617 on Dec. 9 during the American Association for Cancer Research special conference in Toronto - RXRX has a 20 billion pipeline guarantee. Leader in AI drug development, and just bought their competitor.

thirtydelta

Phase I monotherapy safety and pharmacokinetic and pharmacodynamic (PK/PD) data for REC-617 on Dec. 9 during the American Association for Cancer Research special conference in Toronto

Maximum_Wash_8047

The company is expected to report preliminary data from another Phase 1 trial of PYX-106, including PK/pharmacodynamic results, by the end of 2024. Beyond that my main point is that this market reaction doesn't make sense. RBC Capital even increased their price target from $7 to $10. Most of the coverage on this news has been positive (check any article about it beyond the one you mentioned). I believe this is simply an overreaction that will correct soon. Then, of course by mid-2025, there will be new major catalysts, but there simply was no rationale for this huge collapse, especially considering the financial position which looks quite solid as of now considering it's a biotech.

RyannayR11

Their PK study shows that results are with 95% confidence. This leaves a margin of error that is larger than urine or blood tests. Could this limit its applications and demand? I mean, who wants to buy a drug test device with a 5% error rate?

Ashamed-Subject-8573

2: no. Stop listening to hype from techbros trying to sell their products. https://youtu.be/wZRV2H4PK0Q?si=uFF_vZYO1gYQvJou

Piorz

I wanted to look more into it and stand corrected. Here is what I found: If you own put options on stocks of a company that has just declared or filed for bankruptcy, you are in for a huge reward. The delivery and settlement of every stock option is guaranteed by the OCC, Options Clearing Corporation, in the US Market. Whoever sold you that right to sell shares of that company at that higher price is obliged to fulfill that obligation, so your profit is guaranteed. The only question is, what happens when that company files for bankruptcy and trading in its stocks and options are suspended? When that happens, trading of that company’s stocks and options moves to the Over The Counter (OTC) market or what is known as “Pink Sheet” market where you are able to either sell those put options for a profit or exercise the options and sell the stocks for the same profit. Since it is the company that is going illquid and insolvent and not the person or institution who sold you those put options, you are guaranteed your profit and delivery. The most recent example of this are put options on the collasped Lehman Brothers (ex-Ticker : LEH) which filed for bankruptcy on 14 Sep 2008. After filing for bankruptcy, Lehman Brothers’ shares moved from the exchange to the OTC market (Ticker Symbol LEHMQ or LEHMQ.PK) where it traded at $0.05 per share on 18 Sep 2008. That is when put option holders can choose to exercise the put options by buying the shares at $0.05 and selling it at the strike price for a big profit.

shadi150

Ima PK you on OSRS if you don't calm down

Daddy_Dudley10101

Positions or PK 

Enough_Aerie1283

What will outperform S&P index funds like VOO is growth and simple moderate leverage index funds. Individual stock picking runs risks. Simple leverage on indexes gains benefits like self rebalancing and avoidance of tax events while still targeting higher than market growth. A simple growth buy and hold portfolio: Russel 1000 growth ETF ( $VONG) + 2X S&P500 ($SSO) + 2X Nasdaq-100 ($QLD) Following is the 15yr backtest for this portfolio vs. indexes for the cash flow scenario you presented. Drawdown risk can be further mitigated by respecting the S&P 200MA rule for your leveraged ETF positions. https://testfol.io/?d=eJytkEFrhDAQhf%2FKMoeeIkRb2eJtQdpLKYqwUMoiU41u2pjYmCpF%2FO8dkbXbHkoPG3II82be9yYj1Mq8oErQYtNBNELn0Lq8RCcggoDzrcd9usBA6PK7Htx4%2FNbzt1RfJnpUEF1zOgywfM2lrhQ6aTREFapOMCiwO1bKDGvbqZBXVryT65NAqz7J0RqlpK7zQepy7veDiUFrrKuMkoZiPo%2BgsZmTZFfJJuSchqTuRedi2cuSklKTsx9EtYLWQ12Iu18QJ4s3YRez5U3q3hiSWmELoR2BOZ8ODEqLNUR8Yiv2cZfFu9TzL0dO0%2FRf5Ew2rRKbe2sGd9wkp0%2B5WIyH%2BDxGEM7oVc0684e6N7o%2Bl8MfKxymL4KXyvA%3D

kronco

Gray Line bus tour in Honolulu. As we passed the Hilton the guide told everyone to buy PK (a hotel REIT), cause he was "all in" (except, as he lamented, he could not invest in it in his 401K). (I was impressed a tour bus line had a 401K for the employees.) Morninbgstar rates it four stars with a fair market value of $25 (currently at about $15). Several people pulled out their phone when he mentioned it; seems everyone loves a random stock tip :)

Key-Tie2542

I don't think that's true. I think the highly leveraged leisure have dropped due to interest rates. Things like PK (hotel REIT) have dropped, but things like HLT are at ATHs; and PK is rising strong today. Discretionary like BOOT, ANF, TJX, and so forth are way up. I think what we've seen is the interest rate scare, and what we haven't seen is the recession scare.

Emergency-Eye-2165

PK?

Dbow2thedome

PK me in the wildy N00B

Unitedtendies

England literally begging for PK 😂🤡

Quickoneonit

Bro I got strike on my account for saying I’d PK u in osrs lmao

Key_Security_1569

Ya ALTards are crazy man.. VKTX > ALT VKTX catalysts in the next 8 months. 1. Type C meet with FDA 2. Ph2 Venture PK data 3. July earnings poss FDA update 4. VK2809 Nash biopsy data 5. VK2735 oral extra cohorts results 6. Obesity week presentations 7. Vk2735 oral Ph2 starts 8. VK2735 SubQ Ph3 or Ph2b Buyout at 15-20B

IJesusChrist

Dude phase 1 is not exclusively for safety. You collect biomarkers and you can look at pharmacodynamics and titer responses. When a company's trial goes bad in phase 1 they will tell you the primary goal is to establish safety and PK. If it goes good they will tell you they saw exactly what they wanted to see: in this case, seropositivity or seronegative rates, viral titers, etc. Please god.

Bsquared-order66

Obviously I can’t speak as an insider pro and all regions might have different profit times of the year. But since it’s a stock that’s tied to the total company and company’s profit and not that a regions profit, a look at the bigger picture is a must. While Phoenix area could be killing it, the rest of the flagship locations might be dwindling pulling down the entire company / stock price. That’s also assuming stock value was fundamental based and not decided on what someone tweeted about. So all this crap could be just that, crap and PK stock goes boom Tuesday and I look like an dbag. My hope is that your call makes you $ honestly.

Bsquared-order66

https://preview.redd.it/209phy6tqe2d1.jpeg?width=960&format=pjpg&auto=webp&s=2c66ae63667284d6280aece96eb9152540c09b90 I pulled this seasonality chart of PK for you. Although there tends to be a spike at beginning of June it’s a heavy drop off couple weeks later that tends to last till end of August. Not trying to hate or give advice either way. Honestly Just trying to help. Everything I see is pointed against a long play here at this time. Maybe a short spike with a quick few bucks. But with the 4 EMA going under the 8 EMA, I’m staying away unless it’s a put or short.

callmemaverik_

I disagree with the conventions and transient part. Transients absolutely spend more and book higher rates than group rates. Of course, it comes down to the type of hotel and its location. Near a convention center? Absolutely. Location location location. However, I'd feel more comfortable investing in Hilton or Marriott than I would PK. They already have the branding and people already losing trust in AirBNB.

Bsquared-order66

In all sincerity, with an ex wife in the hotel business, the summers aren’t always their busy months. Most hotels rely on convention business and not Transient business (aka families on vacay). Families consist far less revenue both on room rates and practically zero on food and beverage. I’d look toward the stocks chart and watch the 4 and 8 EMA averages on the daily graph and weekly charts. Once that 4 overtakes that 8 it’s gonna go down and vice versa. That’s what appears to be happening with PK on both charts now. So you would be betting against the going current. I try to remind myself not to swim against the current of the market and go with the flow. Wait till the daily chart 8 ema over takes the 4 ema and then for security, if you want more, wait on the weekly chart 8 to overtake the 4 and a modest move should open before tides turn again. But that’s just something I’ve learned. This is not advice of what you should do with your business and $. But I confident hotels make the most income off of conventions staying at their hotel while eating and drinking their food.

lancevancelives

PK = 🚀 That's really all we need. Basically an analyst rating without the confusing numbers. 

Disastrous_Dot_6941

Anyone jump on the PK dd ? Lol

Hightargets

PK follow Up - from DD from last post The post: Pk stock hit its ATH of 24 dollars in 2020 because travel trends in 2020-21 brought 86 billion to the us economy. Pk price is at 17 right now, near its regardly considerable high 18 price zone (it’s 52 week high). Get this, For 2024, statista analyst project a whopping 110 billion dollars year in revenue streams for the American travel industry. In a nut shell PK = Wendy’s combo meal

Unfair-Log2016

Held PK for a long time and it did nothing and went nowhere. Couldn’t break 18 dollars

Quickoneonit

Bro I got a 1st account warning for violence against another user… because I said I’d PK that one mod in the wilderness  wtf is going on here

Quickoneonit

This mod better not post about how we cant talk ab meme stocks tomorrow or else ima PK him while he's in the wilderness

veryworst

D2 and PK vibes need to come back NOW

HardwoodGuy87

I bought 15k bitcoin in 2010, and my dad threw out my laptop with my PK on it.

Mean-Wait6990

Lol, the guy decided to go against the Argentine mentality in PK.

ninkorn

did he miss his PK?

unitegondwanaland

Same. They are on my watch list now. They also just got a $100M injection on top of the good news announced. > SAN DIEGO, March 12, 2024 /PRNewswire/ -- Regulus Therapeutics Inc. (Nasdaq: RGLS), a biopharmaceutical company focused on the discovery and development of innovative medicines targeting microRNAs (the "Company" or "Regulus"), today announced positive topline results from the second cohort of patients in its Phase 1b MAD study of RGLS8429 for the treatment of ADPKD. >The Phase 1b MAD study is a double-blind, placebo-controlled trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics (PK/PD) of RGLS8429 in adult patients with ADPKD. The study is evaluating RGLS8429 treatment across three different weight-based dose levels, including measuring changes in urinary polycystins 1 and 2 (PC1 and PC2), height-adjusted total kidney volume (htTKV), cyst architecture, and overall kidney function. PC1 and PC2 are the protein products of the PKD1 and PKD2 genes and have been shown to inversely correlate with disease severity. The third cohort is being dosed at 3mg/kg of RGLS8429 or placebo every other week for three months. The Company recently added a fourth cohort for an open label fixed dose of 300mg of RGLS8429 dosed every other week for three months. Based on the results from this second cohort, the Company plans to amend the protocol to increase the sample size to up to 30 patients. In addition to PC1 and PC2 and safety, imaging biomarkers will also be evaluated. >SAN DIEGO, March 12, 2024 /PRNewswire/ -- Regulus Therapeutics Inc. (Nasdaq: RGLS), a biopharmaceutical company focused on the discovery and development of innovative medicines targeting microRNAs (the "Company" or "Regulus"), today announced that it has entered into a definitive securities purchase agreement in connection with a private placement to certain institutional investors and other accredited investors. The oversubscribed financing includes participation from new and existing institutional investors, including Adage Capital Partners L.P., Deep Track Capital, the Federated Hermes Kaufmann Funds, New Enterprise Associates (NEA), Octagon Capital, RA Capital Management, and Vivo Capital. Upon the closing of the financing, which is anticipated to occur on or about March 14, 2024, the Company expects to receive gross proceeds of approximately $100 million. The closing of the financing is subject to customary closing conditions.

kronco

\>> a stock that I follow For individual stocks, I find it best to read the full analysis for anything I'm investing in and draw conclusions for that. For example, the morningstar analysis of PK is 2200 words, and covers Business Strategy and Outlook, Financial Strength, Economic Moat, Fair Value and Profit Drivers, Risk and Uncertainty and Capital Allocation. You digest that and make a decision. But the simple charts with thumbs up/down (but/sell/hold), not so much.

kronco

I think it's important to also now what the stars mean. It is different for stocks vs. funds. [https://www.morningstar.com/views/research/ratings](https://www.morningstar.com/views/research/ratings) Funds: *Introduced in 1985, the Morningstar Rating TM for funds, often called the star rating, compares funds against their peers to inform investment decision-making. It's an at-a-glance look at a fund's risk-adjusted performance over the past three years.* Stocks: *The stock star rating is calculated by comparing a stock's current market price with Morningstar's estimate of the stock's fair value. The further the market price is below the fair value, the higher the star rating. A 5-star rating means the stock is trading meaningfully below fair value.* They also list the price range where a stock drops to one star. An example is PK selling at $15.90 with a Fair Value estimate around $26. They give it 5 stars at the current price. If the price was $26 it would be one star. If it hits aprox $21, three stars.

kronco

PK. Park Hotels & Resorts Inc. Bus driver on the #2 pink line in Honolulu recommended it as we drove past the Waikiki Hilton at the end of the tour. That was October when it was at $12. Closed today at $14.89 (up 23%). Pays a 9% dividend. Morningstar \*\*\*\*\* with a Fair Market value estimate of $26 (uncertainty: High). Remember: The best tips come from tour bus drivers and Reddit.

OlliBoi2

 Integrated Cannabis Solutions Inc (IGPK)  Post#  of 46536 GoNext 10   Reply/Post    More  Prev Next  TooFrank  Re: sicofbs post# 41475 Tuesday, 01/16/2024 9:10:08 AM OTC/SEC Disclosure is a legal document unlike a PR or Tweet. Quarterly Report For the period ending September 30, 2023 (the “Reporting Period”) https://www.otcmarkets.com/otcapi/company/financial-report/389366/content The Company has rescinded its agreements with Consolidated, Global, and Tahoe, and dissolved Houdini Group. Management has resigned, and new management has taken over. The new entity is JFH Digital ECommerce Corp. They will be making updates on OTC and the State of NV over the coming weeks. The September 30, 2023 financials reflect the Company prior to JFH merging in. Closing, and the shares of Series A were issued to the incoming company along with shares of common stock.All officers and directors resigned, and below is a list of the new incoming management team: officers and directors resigned, and below is a list of the new incoming management team: 1. CEO: Wang Dejun - Room #1801, Building #5, Vanke Jinyu International Garden, No.144, Houjie Section, Guantai Road, Houjie Town, Dongguan City, Guangdong Province, China 2. CFO: Xie Weiji - No. 3, Changgang Village, Hedong Village Committee, Longjing Town, Qingxin County, Guangdong Province, China 3. Yang Lanfang - Chishuiwan International Hotel, No. 1 General Road, Shexian County, Handan City, Hebei Province, China 4. Zhu Henian - Room #302, Unit one, Building #2, International Industry Center, Zhanggong District, Ganzhou City, Jiangxi Province, China 5. Wang Wei - Building #16, Sunshine Garden, Chengdong Street, Qianjiang District, Chongqing City, China When it comes to the OTC and money, a tick can swallow a cow. 👍️ 1   Share  Replies (3)  Reply/Post    More  Prev Next IGPK Intergrated Cannabis Solutions Inc (PK) 0.01085  -0.00205 (-15.89%) Volume:96,184,373Day Range:0.0093 - 0.0133Bid:0.0107Ask:0.011Last Trade Time:4:00:14 PM ESTTotal Trades:1,667 1D 1M 3M 6M 1Y 5Y  IGPK Detailed Quote   InvestorsHub NewsWire FEATURED Goldshore Announces an Indicated Mineral Resource Estimate of 1,535Koz Contained Gold at 1.23 g/t Au and an Inferred Mineral Resource Estimate of 5,198Koz Contained Gold at 1.11 g/t Au at the Moss Gold Project • Feb 6, 2024 10:22 AM FEATURED Music Licensing, Inc. (OTC: SONG) to Provide Shareholder Update and Financial Statements for Year-End 2023 • Feb 6, 2024 9:45 AM FEATURED Golden Heaven Group Holdings Ltd. Releases 2024 Chairman's Letter to Shareholders • Feb 6, 2024 9:09 AM Toggle3D.ai Announces its Breakthrough AI Increases 3D Model Production For Ecommerce Productivity by 100% • TGGL • Feb 6, 2024 10:00 AM ARway.ai The Spatial Computing Company Launches Apple Vision Pro Compatibility and Early Access for ARwayKit SDK For Augmented Reality Navigation • ARWYF • Feb 6, 2024 10:00 AM Swifty Global Announces Outstanding Performance in 2023 Shareholder Report • DRCR • Feb 6, 2024 9:30 AM Start posting your company's news Only $200 per official company press release!  © Copyright 2024    About Us Terms of Service Privacy Policy Advertise With Us Data Accreditations Disclaimer FAQ Handbook Q&A Forum Contact Us Corporate Solutions Educational Channel Stock Market 101 Investor Help Forum iHub NewsWire    

NOT_MartinShkreli

Thanks man. I appreciate it. I do believe in the company but the key to a bubble is most others don’t notice it and u think this is one I bought in when they started working with pharmacy PK data to dose busulfan and a handful of other drugs. However I’ve seen not much advancement in that space other than a couple new drugs (gotta feed it the patient data + years to validate the model as a clinical trial basically) I LOVE NVDA but I’m smart enough to know that when WSB is pumping it and the mentions are going crazy …. The top is in. It happened with gamestop. It happened with TSLA. It happened with most EV companies. It happened with SNAP, I could go on I will buy the dip … in this case I’m selling a top